Induction of Ca signaling and cytotoxic responses of human lung fibroblasts upon an antihistamine drug oxatomide treatment and evaluating the protective effects of Ca chelating.

Background: Oxatomide, an antihistamine drug of the diphenylmethylpiperazine family, has anti-inflammatory effects in airway disease. Because oxatomide was shown to cause diverse physiological responses in several cell models, the impact of oxatomide on Ca signaling and its related physiological effects has not been explored in IMR-90 human fetal lung fibroblasts.

Objectives: This study assessed the effect of oxatomide on cell viability and intracellular free Ca concentrations ([Ca]) and examined whether oxatomide-induced cytotoxicity through Ca signaling in IMR-90 cells.

Investigation of the mechanisms behind ochratoxin A-induced cytotoxicity in human astrocytes and the protective effects of N-acetylcysteine.

Ochratoxin A (OTA) is a type of mycotoxin commonly found in raw and processed foods. It is essential to be aware of this toxin, as it can harm your health if consumed in high quantities. OTA can induce toxic effects in various cell models.

Exploration of beauvericin's toxic effects and mechanisms in human astrocytes and N-acetylcysteine's protective role.

Beauvericin (BEA) is a newly identified mycotoxin produced by various Fusarium species, and its contamination in food and animal feed is widespread globally. This mycotoxin demonstrates cytotoxic effects by inducing oxidative stress in multiple models. Furthermore, evidence indicates that BEA possesses diverse toxic activities, making it a promising candidate for toxicological research.

Mechanical Properties and Fatigue Life Analysis of Motion Cables in Sensors under Cyclic Loading.

Motion cables, which are widely used in aero-engine sensors, are critical components that determine sensor stability. Because motion cables have unique motion characteristics, the study of their mechanical properties and reliability is very important. In addition, motion cables are complex in structure and cannot be applied to conventional fixed cable research methods.

Involvement of oxidative stress-related apoptosis in chlorpyrifos-induced cytotoxicity and the ameliorating potential of the antioxidant vitamin E in human glioblastoma cells.

Organophosphate pesticides (OPs), which are among the most widely used synthetic chemicals for the control of a wide variety of pests, are however associated with various adverse reactions in animals and humans. Chlorpyrifos, an OP, has been shown to cause various health complications due to ingestion, inhalation, or skin absorption. The mechanisms underlying the adverse effect of chlorpyrifos on neurotoxicity have not been elucidated.

Evaluation of the mycotoxin patulin on cytotoxicity and oxidative stress in human glioblastoma cells and investigation of protective effect of the antioxidant N-acetylcysteine (NAC).

Mycotoxins are secondary metabolites produced by various kinds of fungi that can induce disease in humans. The fungal species Penicillium expansum produces patulin (CHO), a polyketide lactone mycotoxin found in fruits. Patulin is classified as noncarcinogen; however, recently, it has been associated with harmful effects on the central nervous system.

Investigation of Cytotoxicity and Oxidative Stress Induced by the Pyrethroid Bioallethrin in Human Glioblastoma Cells: The Protective Effect of Vitamin E (VE) and Its Underlying Mechanism.

Bioallethrin belongs to the family of pyrethroid insecticides. Previous studies have shown that bioallethrin affected the function of muscarinic receptor and subsequently induced neurotoxicity in different brain models. Reactive oxygen species (ROS) are generated in the metabolic course of the human body, which can cause human damage when overactivated.

The Impact of the Antipsychotic Medication Chlorpromazine on Cytotoxicity through Ca Signaling Pathway in Glial Cell Models.

Chlorpromazine, an antipsychotic medication, is conventionally applied to cope with the psychotic disorder such as schizophrenia. In cellular studies, chlorpromazine exerts many different actions through calcium ion (Ca) signaling, but the underlying pathways are elusive. This study explored the effect of chlorpromazine on viability, Ca signaling pathway and their relationship in glial cell models (GBM 8401 human glioblastoma cell line and Gibco® Human Astrocyte (GHA)).

Inhibition of the pesticide rotenone-induced Ca signaling, cytotoxicity and oxidative stress in HCN-2 neuronal cells by the phenolic compound hydroxytyrosol.

Rotenone, a plant-derived pesticide belonging to genera Derris and Lonchorcarpus, is an inhibitor of NADH dehydrogenase complex. Studies have shown that rotenone was applied as a neurotoxic agent in various neuronal models. Hydroxytyrosol [2-(3,4-dihydroxyphenyl)-ethanol] is a natural phenolic compound found in the olive (Olea europaea L.

Investigation of cytotoxic effect of the bufanolide steroid compound cinobufagin and its related underlying mechanism in brain cell models.

Cinobufagin, a bufadienolide of toad venom of Bufo bufo gargarizans, is used as a cardiotonic, central nervous system (CNS) respiratory agent, as well as an analgesic and anesthetic. However, several research showed that bufadienolide has a few side effects on the CNS, such as breathlessness or coma. Although cinobufagin was shown to display pharmacological effects in various models, the toxic effect of cinobufagin is elusive in brain cell models.

Mechanisms underlying protective effects of vitamin E against mycotoxin deoxynivalenol-induced oxidative stress and its related cytotoxicity in primary human brain endothelial cells.

Fusarium mycotoxins are one of the largest families of mycotoxins. Among these mycotoxins, deoxynivalenol is the most widespread pollutant of grains. However, the mechanism underlying the effect of deoxynivalenol on cytotoxicity in human brain endothelial cells was still unclear.

Mechanism of action of a diterpene alkaloid hypaconitine on cytotoxicity and inhibitory effect of BAPTA-AM in HCN-2 neuronal cells.

Hypaconitine, a neuromuscular blocker, is a diterpene alkaloid found in the root of Aconitum carmichaelii. Although hypaconitine was shown to affect various physiological responses in neurological models, the effect of hypaconitine on cell viability and the mechanism of its action of Ca handling is elusive in cortical neurons. This study examined whether hypaconitine altered viability and Ca signalling in HCN-2 neuronal cell lines.

Mechanism of a methylxanthine drug theophylline-induced Ca signaling and cytotoxicity in AML12 mouse hepatocytes.

Theophylline is a methylxanthine drug used in therapy for respiratory diseases. However, the impact of theophylline on Ca signaling has not been explored in liver cells. This study examined whether theophylline affected Ca homeostasis and its related cytotoxicity in AML12 mouse hepatocytes.

Exploration of thioridazine-induced Ca signaling and non-Ca-triggered cell death in HepG2 human hepatocellular carcinoma cells.

Thioridazine, belonging to first-generation antipsychotic drugs, is a prescription used to treat schizophrenia. However, the effect of thioridazine on intracellular Ca concentration ([Ca]) and viability in human liver cancer cells is unclear. This study examined whether thioridazine altered Ca signaling and viability in HepG2 human hepatocellular carcinoma cells.

Ca signaling as a mechanism of haloperidol-induced cytotoxicity in human astrocytes and assessing the protective role of a Ca chelator.

Haloperidol, a typical antipsychotic medication, has been shown to possess various biological effects in different brain models. However, the impact of haloperidol on Ca signaling in astrocytes is elusive. This study explored the effect of haloperidol on cytosolic free Ca levels ([Ca]) and viability, and established these two connections in Gibco® Human Astrocytes (GHAs) and DI TNC1 rat astrocytes.

Cytotoxic Effects of Mesaconitine, the Aconitum carmichaelii Debx Bioactive Compound, on HBEC-5i Human Brain Microvascular Endothelial Cells: Role of Ca Signaling-Mediated Pathway.

Mesaconitine, one of Aconitum carmichaelii Debx bioactive compounds, was shown to evoke Ca homeostasis and its related physiological effects in endothelial cell types. However, the effect of mesaconitine on Ca signaling and cell viability in human brain microvascular endothelial cells is unclear. This study focused on exploring whether mesaconitine changed cytosolic Ca concentrations ([Ca]), affected cell viability, and established the relationship between Ca signaling and viability in HBEC-5i human brain microvascular endothelial cells.

Investigation of effect of tectorigenin (O-methylated isoflavone) on Ca signal transduction and cytotoxic responses in canine renal tubular cells.

Tectorigenin, a traditional Chinese medicine, is isolated from the flower of plants such as Pueraria thomsonii Benth. It is an O-methylated isoflavone, a type of flavonoid. Previous studies have shown that tectorigenin evoked various physiological responses in different models, but the effect of tectorigenin on cytosolic-free Ca levels ([Ca]) and cytotoxicity in renal tubular cells is unknown.

Exploring the impact of a naturally occurring sapogenin diosgenin on underlying mechanisms of Ca movement and cytotoxicity in human prostate cancer cells.

Literature has shown that diosgenin, a naturally occurring sapogenin, inducedcytotoxic effects in many cancer models. This study investigated the effect of diosgenin on intracellular Ca concentration ([Ca ]i) and cytotoxicity in PC3 human prostate cancer cells. Diosgenin (250-1000 μM) caused [Ca ]i rises which was reduced by Ca removal.

Mechanisms underlying the effect of an oral antihyperglycaemic agent glyburide on calcium ion (Ca ) movement and its related cytotoxicity in prostate cancer cells.

Glyburide is an agent commonly used to treat type 2 diabetes and also affects various physiological responses in different models. However, the effect of glyburide on Ca movement and its related cytotoxicity in prostate cancer cells is unclear. This study examined whether glyburide altered Ca signalling and viability in PC3 human prostate cancer cells and investigated those underlying mechanisms.

Action of chlorzoxazone on Camovement and viability in human oral cancer cells.

Chlorzoxazone is a skeletal muscle relaxant. However, the effect of chlorzoxazone on intracellular Ca concentrations ([Ca]) in oral cancer cells is unclear. This study examined whether chlorzoxazone altered Ca signaling and cell viability in OC2 human oral cancer cells.

The exploration of effect of terfenadine on Ca signaling in renal tubular cells.

Terfenadine, an antihistamine used for the treatment of allergic conditions, affected Ca-related physiological responses in various models. However, the effect of terfenadine on cytosolic free Ca levels ([Ca]) and its related physiology in renal tubular cells is unknown. This study examined whether terfenadine altered Ca signaling and caused cytotoxicity in Madin-Darby canine kidney (MDCK) renal tubular cells.

Uncovering malathion (an organophosphate insecticide) action on Ca signal transduction and investigating the effects of BAPTA-AM (a cell-permeant Ca chelator) on protective responses in glial cells.

Malathion, one of commonly used organophosphate insecticides, has a wide range of toxic actions in different models. However, the effect of this compound on Ca homeostasis and its related cytotoxicity in glial cells is elusive. This study examined whether malathion evoked intracellular Ca concentration ([Ca]) rises and established the relationship between Ca signaling and cytotoxicity in normal human astrocytes, rat astrocytes and human glioblastoma cells.

Exploration of the effect of the alkaloid colchicine on Ca handling and its related physiology in human oral cancer cells.

Objective: Colchicine, extracted from plants of the genus Colchicum, is a commonly prescribed drug for inflammatory diseases. It has been shown that colchicine affected various physiological responses in different models. However, the effect of colchicine on cytosolic free Ca levels ([Ca]) and its related physiology in human oral cancer cells is unknown.

The protective effects of the antioxidant N-acetylcysteine (NAC) against oxidative stress-associated apoptosis evoked by the organophosphorus insecticide malathion in normal human astrocytes.

Malathion is one of the most widely used organophosphorus insecticides in agriculture. However, malathion may be involved in the etiology of human brain dysfunction. Induction of ROS has been proposed as a mechanism of malathion-induced poisoning cases, but there are few data regarding the effects of malathion on oxidative stress-associated neurotoxicity in human glial cells.

Exploration of Niflumic Acid’s Action on Ca²⁺ Movement and Cell Viability in Human Osteosarcoma Cells.

Niflumic acid, a drug used for joint and muscular pain, affected Ca²⁺ signaling in different models. However, the effect of niflumic acid on Ca²⁺ homeostasis and Ca²⁺-related physiology in human osteosarcoma cells is unknown. This study examined the effect of niflumic acid on cytosolic free Ca²⁺ concentrations ([Ca²⁺]i) in MG63 human osteosarcoma cells.