The Chinese Society of Hepatology position statement on the redefinition of fatty liver disease.

Fatty liver disease associated with metabolic dysfunction is of increasing concern in mainland China, the world's most populous country. The incidence of fatty liver disease is highest in China, surpassing the incidence in European countries and the USA. An international consensus panel recently published an influential report recommending a novel definition of fatty liver disease associated with metabolic dysfunction.

Brucellar reproductive system injury: A retrospective study of 22 cases and review of the literature.

Objective: We aimed to describe the clinical characteristics and prognosis of 22 patients with -induced reproductive system injury.

Methods: We assessed 22 patients with reproductive system injury between 2010 and 2018 at The First Affiliated Hospital of Xinjiang Medical University.

Results: The disease is predominant in men.

Childhood pneumonia due to brucellosis: A case report.

Rationale: Childhood brucellosis is a significant community health problem. It may imitate other conditions and may be misdiagnosed. Pulmonary involvement is a rare complication of childhood brucellosis.

-induced thrombocytopenia: a retrospective study of 16 patients.

Objective: We aimed to describe the clinical characteristics and treatment outcomes of 16 patients with -induced thrombocytopenia.

Methods: We assessed 16 patients with -induced thrombocytopenia between 2012 and 2016 in The First Affiliated Hospital of Xinjiang Medical University. The diagnosis of -induced thrombocytopenia was ≤100,000 platelets/mm.

[Comparison of HLA-DRB1, HLA-DQB1 and HLA-DPB1 gene polymorphisms and haplotypes in partial Han and Uyghur populations of Xinjiang region].

Objective: To investigate the gene polymorphism and haplotype distribution characteristics of human leukocyte antigen (HLA)-DRB1, -DQB1 and -DPB1 in Han and Uyghur populations from the Xinjiang Uyghur Autonomous Region.

Methods: The polymerase chain reaction-sequencing-based typing (PCR-SBT) was applied to analyze the HLA-DRB1, HLA-DQB1 and HLA-DPB1 genotypes in 188 Han and 90 Uyghur individuals. The gene frequencies were calculated by direct counting method, and the haplotype frequencies were obtained by the maximum likelihood method with Arlequin3.

Single Nucleotide Polymorphisms in P2X7 Gene Are Associated with Serum Immunoglobulin G Responses to Mycobacterium tuberculosis in Tuberculosis Patients.

Objective: Our study investigated the association between single nucleotide polymorphisms (SNPs) in P2X7 gene and serum immunoglobulin G (IgG) responses to mycobacterium tuberculosis (MTB) in TB patients.

Methods: A total of 103 TB patients were enrolled as case group and 87 healthy individuals at same geographical region as control group. The SNP detection of 1513A>C and -762T>C was performed using PCR-RFLP, and the levels of serum IgG responses to MTB in all subjects were determined.

[Identification of A Novel HLA Allele DRB1 * 16:36 by Sequencing-Based Typing].

Objective: To identify a novel HLA allele DRB1 * 16:36 from a Uygur woman.

Methods: PCR-SBT technology was applied to the extracted DNA for genotyping, and a possible new gene was sequenced by using sequence specific primers and single stranded SBT. This novel allele was compared with known most homologous gene sequences and their difference was analyzed.

A broad-range survey of ticks from livestock in Northern Xinjiang: changes in tick distribution and the isolation of Borrelia burgdorferi sensu stricto.

Background: Borreliosis is highly prevalent in Xinjiang Uygur Autonomous Region, China. However, little is known about the presence of Borrelia pathogens in tick species in this region, in addition Borrelia pathogens have not been isolated from domestic animals.

Methods: We collected adult ticks from domestic animals at 19 sampling sites in 14 counties in northern Xinjiang from 2012 to 2014.

The viability and protein expression of Beijing/W lineage Mycobacterium tuberculosis circulating in Xinjiang, China.

Beijing/W lineage strains of Mycobacterium tuberculosis spread faster than other strains, tend to be more virulent and frequently associated with drug resistance. In this study, to distinguish the characteristics of Beijing/W lineage and non-Beijing/W lineage M. tuberculosis, we assessed the growth between the two groups under conditions of hypoxia, nutrient starvation, and intracellular growth in murine macrophages.