Salvia miltiorrhiza polysaccharide mitigates AFB1-induced liver injury in rabbits.

Aflatoxin B1 (AFB1) is one of the common dietary contaminants worldwide, which can harm the liver of humans and animals. Salvia miltiorrhiza polysaccharide (SMP) is a natural plant-derived polysaccharide with numerous pharmacological activities, including hepatoprotective properties. The purpose of this study is to explore the intervention effect of SMP on AFB1-induced liver injury and its underlying mechanisms in rabbits.

Health Economics of Selective Early Rescue Surfactant Administration and Standard Surfactant Administration for Newborns With Respiratory Distress Syndrome.

Objective: To quantify the effect of early rescue surfactant administration techniques for preterm infants with respiratory distress syndrome (RDS) from a health care delivery system perspective.

Methods: A cost-consequence model was developed based on previously published literature to compare the health economic impact of implementing early surfactant administration strategies vs standard surfactant administration via endotracheal intubation and mechanical ventilation (MV).

Results: Early rescue surfactant treatment strategies are associated with a decrease in the number of patients requiring MV, cumulative MV days, and rate of neonatal complications.

Salvia miltiorrhiza polysaccharides alleviates florfenicol-induced liver metabolic disorder in chicks by regulating drug and amino acid metabolic signaling pathways.

Excessive and nonstandard use of florfenicol (FFC) can damage animal body, pollute ecological environment, and even harm human health. The toxic and side effects of FFC directly affect the production performance of poultry and the safe supply of chicken-related food. Salvia miltiorrhaza polysaccharides (SMPs) are natural macromolecular compounds, and were proved to have the effect of protecting animal liver.

The impact of increasing multitarget stool DNA use among colorectal cancer screeners in a self-insured US employer population.

In the United States (US), colorectal cancer (CRC) is the second leading cause of cancer-related deaths. With the majority of the US population covered by employer-based health plans, employers can play a critical role in increasing CRC screening adherence, which may help avert CRC-related deaths. Therefore, it is important for self-insured employers to consider the impact of appropriate utilization of CRC screening options.

The health economic impact of varying levels of adherence to colorectal screening on providers and payers.

Aims: To examine the impact of increasing multi-target stool DNA test (mt-sDNA [Cologuard]) utilization for colorectal cancer (CRC) screening in cohorts aged 50-75 and 45-75 years old with varying levels of adherence from the perspectives of integrated delivery networks (IDNs) and payers.

Materials And Methods: We developed a budget impact model that simulates CRC screening with colonoscopy over a 10-year time horizon, fecal immunochemical test (FIT), and mt-sDNA according to the United States Preventive Services Task Force and American Cancer Society guidelines for average risk adults. We evaluated varying levels of screening adherence for a status quo scenario and for an increased mt-sDNA utilization scenario, from the IDN and payer perspectives.

Residential radon exposure and hypertensive disorders of pregnancy in Massachusetts, USA: A cohort study.

Background: Exposure to ionizing radiation has been associated with hypertension, but the relationship between residential radon exposure and hypertensive disorders of pregnancy (HDP) has not been examined.

Methods: We used the Massachusetts Birth Registry of Vital Records from 2001 to 2015 including women with a singleton pregnancy without prior hypertension. The binary outcome (HDP) included gestational hypertension and pre-eclampsia cases and was assessed using birth certificate data.

Citrate-enhanced release of arsenic during pyrite oxidation at circumneutral conditions.

The release of arsenic (As) from the oxidation of As-rich pyrite is an important source of the high arsenic in groundwater. As a widespread low-molecular-weight organic acid, citrate plays an important role on the cycling of Fe(II)/Fe(III) through complexation in circumneutral subsurface environments, while the influence of citrate on the release of As from the oxidation of As-rich pyrite is poorly understood. In this study, As was loaded onto pyrite particles under anoxic conditions, and its release was investigated in the presence of 0-1 mM citrate at pH 7.

[Low-dose capsaicin decreases lung ischemia-reperfusion injury and underlying mechanism in rats].

Objective: To explore the effects of low-dose capsaicin (CAP) on lung ischemia-reperfusion (IR) injury and elucidate its possible mechanisms in rats.

Methods: A total of 32 Sprague-Dawley rats were randomly divided into 4 groups of S (sham thoracotomy and mechanical ventilation for 5.0 h), IR (an occlusion of left pulmonary hilus for 1.

[Clinical application of the modified laryngeal mask airway for endobronchial ultrasound-guided transbronchial needle aspiration biopsy].

Objective: To observe the clinical application of the modified laryngeal mask airway for endobronchial ultrasound-guided transbronchial needle aspiration biopsy.

Method: By the induction of the general anesthesia, 42 patients undergoing endobronchial ultrasound-guided transbronchial needle aspiration biopsy between september 2012 and may 2013 were managed with the modified laryngeal mask airway. The group consisted of 42 male patients aged 56 years to 67 years, with a median age of 61.

[Comparative a nimble of monitoring indicator, explore the superiority about Supreme dual-chamber laryngeal mask used for cesarean section anesthesia].

Objective: Explore the feasibility and superiority about Supreme double-lumen laryngeal mask airway for cesarean section anesthesia.

Methods: From March 2011 to March 2012, a total of 300 patients with American Society of Anesthesiologists (ASA) I or II foot of cesarean section in full-term pregnant women for the first time production of Quanzhou Women's and Children's Hospital were recruited, authenticated by Hospital Ethics Committee, they were randomly divided into three groups (Random number table), dual-chamber in the LMA group (A group of 100 cases), tracheal intubation group (B group of 100 cases) and spinal anesthesia group (C group of 100 cases). ECG, SpO2, MAP, heart rate, Narcotrend and Apgar scores were observed.

Interaction between lung cancer cell and myofibroblast influenced by cyclic tensile strain.

Using a cell culture chip with a deformable substrate driven by a hydraulic force, we investigated the motility of cancer cells affected by myofibroblasts undergoing cyclic tensile strain (CTS). CTS reduced both the expression of α-smooth muscle actin in the myofibroblast and the ability of the myofibroblast to accelerate cancer cell migration. However, with the treatment of a pro-inflammatory factor interleukin-1β on the myofibroblasts, the effects of CTS on the myofibroblast were diminished.

[Comparison of hemodynamic responses to orotracheal intubation with laryngeal mask airway CTrach™ and laryngoscope under general anesthesia].

Objective: To compare the hemodynamic responses to orotracheal intubation with Laryngeal Mask Airway CTrach™ and Laryngoscope under general anesthesia.

Methods: 60 adult patients, scheduled for the elective gynecologic surgery under general anesthesia requiring the orotracheal intubation, were randomly allocated to either the CTrach (C) group or the Laryngoscope (D) group. After a standard intravenous anesthetic induction, the orotracheal intubation was performed.