Emotional and visual responses to trypophobic images with object, animal, or human body backgrounds: an eye-tracking study.

Background: Trypophobia refers to the visual discomfort (e.g., disgust or anxiety) experienced by some people when viewing clusters of bumps or holes.

Handgrip strength and body mass index exhibit good predictive value for sarcopenia in patients on peritoneal dialysis.

Aim: The diagnosis of sarcopenia in patients on peritoneal dialysis (PD) in clinics is limited owing to its relatively complicated process and the need for expensive assessment equipment. This study aimed to develop and validate sex-specific nomogram models based on body mass index (BMI), handgrip strength, and other routine follow-up examination indicators to predict sarcopenia in patients on PD.

Methods: From March 2023 to February 2024, 699 eligible patients were recruited from the PD centers of two tertiary hospitals in southeastern China.

Cepharanthine inhibits the proliferation of glioblastoma cells by blocking the autophagy-lysosomal pathway.

Cepharanthine (CEP) is a Stephania cepharantha-derived bioactive alkaloid that can inhibit the progression of numerous tumors. However, the effects and specific mechanisms of CEP performance in glioblastoma (GBM) remain unclear. Thus, this study focused on exploring the effects of CEP on GBM and clarifying the underlying mechanisms.

Sufficient condition for reliable logic operations in an over damped bistable system driven by Gaussian white noise.

In this paper, we investigate an overdamped bistable system subject to Gaussian white noise and logical inputs. By solving and estimating the steady distribution of the corresponding Fokker-Planck equation and considering the two essential features of the reliable logic operations (RLOs)-initial value independence and sign invariance-we establish the sufficient condition for RLO occurrence and identify parametric resonance phenomena in the system. Our numerical simulations confirm the reliability and accuracy of the theoretical results.

The Impact of Cohort Management on Disease Perception, Fear of Disease Progression, Nutritional Status, and Quality of Life in Patients with Lymphoma.

Objective: This study aims to investigate the impact of cohort management on illness perception, fear of disease progression, nutritional status, and quality of life among patients with lymphoma.

Methods: A total of 128 cases of lymphoma patients admitted to Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, between April 2020 and November 2021 were included as research participants. The patients were randomly assigned to two groups: a 64-member control group and a 64-member observation group.

Perceptions of utilizing a symptom self-management app for breast cancer patients receiving outpatient chemotherapy.

Purpose: Breast cancer (BC) patients who are undergoing outpatient chemotherapy encounter difficulties in symptom self-management at home. We have developed a mobile app with the support of self-regulation activities and nurse-led social service to empower self-management of BC patients during outpatient chemotherapy. The study aimed to explore the perceptions of breast cancer patients and nurses in utilizing an app with the functions of proactive nursing support and empowerment.

Optimal timing for awake prone positioning in Covid-19 patients: Insights from an observational study from two centers.

Background: The widespread application and interest in awake prone positioning stems from its ease and availability and its ability to enhance patients' oxygenation. Nevertheless, due to the absence of consensus over the regimen of awake prone positioning, the efficacy of awake prone positioning remains uncertain.

Objective: To explore the optimal regimen for awake prone positioning, including the timing of initiation, ideal daily duration, and strategies for improving patient comfort and encouraging adherence.

accelerates the progression of hepatocellular carcinoma via the ERK/AKT/mTOR signaling pathway.

Hepatocellular carcinoma (HCC) is a significant contributor to global cancer-related deaths, leading to high mortality rates. However, the pathogenesis of HCC remains unclear. In this research, by the bioinformatics data analysis, we found that elevated expression correlated with advanced disease and predicted diminished overall survival (OS) in HCC patients.

Astrocyte-Ablation of Increases Anxiety-Like Behavior in Adult Male Mice.

Background: Astrocytes are essential for synaptic transmission, and their dysfunction can result in neuropsychiatric disorders such as anxiety and depression. Many studies have shown that global knockout of Melatonin receptor 2 () is associated with the development of various mental disorders.

Aim: This study aimed to investigate the effects of astrocyte ablation of on cognitive function and anxiety-like behavior in mice, as well as the potential biological mechanisms.

Network analysis of depression and anxiety symptoms in Chinese rheumatoid arthritis patients.

Background: Rheumatoid arthritis (RA) patients are susceptible to comorbid anxiety and depression. From the network model perspective, comorbidity is due to direct interactions between depression and anxiety symptoms. The objective of this study was to assess the network structure of depression and anxiety symptoms in Chinese RA patients and identify the central and bridge symptoms as well as how depression and anxiety symptoms are related to quality of life (QoL) in the network.

Determinants of Depressive Symptoms Among Patients with Rheumatoid Arthritis in China: A Structural Equation Model.

Background: This study aimed to examine how personality traits, social support and clinical features including pain, disease activity, functional status, sleep quality, and fatigue influence on depressive symptoms in Chinese rheumatoid arthritis (RA) patients.

Methods: This study was conducted from November, 2022 to June, 2023 among Chinese RA patients. Pain, disease activity, functional status, sleep quality, fatigue, social support, personality traits, and depressive symptoms were assessed.

Psychological status is associated with the perceived illness stigma in Chinese systemic lupus erythematosus patients.

Systemic lupus erythematosus (SLE) might affect all aspects of life including perceived stigma, but research on perceived stigma is still in its infancy among SLE patients. The objective of this study was to assess the relationships among socioeconomic status, clinical parameters, disease activity, quality of life, depression, and the perceived stigma in Chinese patients with SLE. A total of 133 SLE patients (mean age: 39.

The mechanism of LZ-8-mediated immune response in the mouse model of Parkinson's disease.

Parkinson's disease (PD) is associated with microscopic changes in the brain, particularly substantia nigra (SN). Ganoderma lucidum immunoregulatory protein (rLZ-8) is might confer protective effects against PD. We developed a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced murine model of PD and determined the effects of rLZ-8 on molecular and cellular components of SN and whole brain tissue.

Transcriptional activation of CSTB gene expression by transcription factor Sp3.

CSTB has been reported to be associated with the pathogenesis of many malignant tumors, especially hepatocellular carcinoma (HCC). However, how the expression of this gene is regulated is largely unknown. We initially cloned and analyzed the promoter region of the CSTB gene by luciferase assay and the Sp3 binding site (CCCCGCCCCGCG) was found in it.

Application of artificial intelligence in glioma researches: A bibliometric analysis.

Background: There have been no researches assessing the research trends of the application of artificial intelligence in glioma researches with bibliometric methods.

Purpose: The aim of the study is to assess the research trends of the application of artificial intelligence in glioma researches with bibliometric analysis.

Methods: Documents were retrieved from web of science between 1996 and 2022.

Development and Application of Global Health Events-Mental Stress Scale for Assessment of Medical Staff's Acute Mental Stress Responses.

Background: Medical workers have been increasingly involved in emergent public health events, which can lead to severe stress. However, no standardized, officially recognized, unified tool exists for mental distress measurement in medical workers who experienced the public health events.

Purpose: In the present study, we propose the Global Health Events-Mental Stress Scale (GHE-MSS), as a revised version of the Impact of Event Scale-Revision (IES-R), for assessment of medical workers' acute mental stress responses within one month and their chronic mental stress responses within six months after major health events.

Regulation of the Human IL-10RB Gene Expression by Sp8 and Sp9.

Background: Interleukin-10 (IL-10) is a classic anti-inflammatory cytokine that exerts its effects via the receptor complexes IL-10RA and IL-10RB. Loss of IL-10RB results in many diseases. Moreover, IL-10RB is closely associated with neuronal survival and synaptic formation.

Mitochondrial DNA variant spectrum and the association with chronic tic disorders.

Background And Purpose: Tic disorders (TDs) are childhood onset neuropsychiatric disorders characterized by single or multiple sudden, rapid, recurrent, and motor tics and/or vocal tics. Several nuclear genes that are involved in mitochondrial functions suggest a potential role of mitochondria in TDs.

Methods: To evaluate the association of mitochondrial DNA (mtDNA) variants with TDs, we screened the whole mitochondrial genomes in 493 TD patients and 109 age- and sex-matched healthy controls using next generation sequencing technology.

Changes of Cytokines in Children With Tic Disorder.

Tic disorder (TD) is a common childhood-onset disease associated with abnormal development of brain networks involved in the motor and sensory processing. The underlying pathophysiological mechanisms in TD are still unclear. An involvement of immune mechanisms in its pathophysiology has been proposed.

Role of SIRT2 in regulating the dexamethasone-activated autophagy pathway in skeletal muscle atrophy.

The proteolytic autophagy system is involved in a major regulatory pathway in dexamethasone (Dex)-induced muscle atrophy. Sirtuin 2 (SIRT2) is known to modulate autophagy signaling, exerting effects in skeletal muscle atrophy. We examined the effects of SIRT2 on autophagy in Dex-induced myoatrophy.

The Validity of the GLIM Criteria for Malnutrition in Hospitalized Patients with Gastric Cancer.

Background: The Global Leadership Initiative on Malnutrition (GLIM) has recently proposed a consensus on the criteria to diagnose malnutrition. The validity of the new criteria to detect malnutrition is still being explored. Therefore, this study aimed to verify the validity of the GLIM criteria for malnutrition in hospitalized patients with gastric cancer (GC) using the Patient-Generated Subjective Global Assessment (PG-SGA) as a comparator.

LEF1-AS1 accelerates tumorigenesis in glioma by sponging miR-489-3p to enhance HIGD1A.

Long non-coding (lncRNA) lymphoid enhancer-binding factor 1 antisense RNA 1 (LEF1-AS1) has been validated to be implicated in manifold cancers, whereas its function in glioma has not been understood thoroughly. Hence, in this study, we tested that LEF1-AS1 expression was significantly upregulated in glioma tissues and cell lines. Besides, knockdown of LEF1-AS1 repressed cell proliferation while activated apoptosis in glioma cells in vitro, and also suppressed tumor growth in vivo.

Analysis of factors contributing to postoperative body weight change in patients with gastric cancer: based on generalized estimation equation.

Aims: The study aimed to explore factors contributing to body weight change over time in gastric cancer patients after gastrectomy, in order to find risk factors to implement nutritional intervention beforehand.

Methods: A cohort of gastric cancer patients who were treated with gastrectomy from January to March 2019 at a university affiliated hospital in Shanghai were consecutively identified in this study. Demographics, disease related information, nutrition knowledge, attitude, and practice score were collected before gastrectomy.