Patient-reported outcome measures for medication treatment satisfaction: a systematic review of measure development and measurement properties.

Background: Medication Treatment Satisfaction (M-TS) from the patients' perspective is important for comprehensively evaluating the effect of medicines. The extent to which current patient-reported outcome measures (PROMs) for M-TS are valid, reliable, responsive, and interpretable remains unclear. To assess the measurement properties of existing PROMs for M-TS and to highlight research gaps.

Research Progress on the Effect and Mechanism of Exercise Intervention on Sarcopenia Obesity.

With the increasingly severe situation of obesity and population aging, there is growing concern about sarcopenia obesity (SO). SO refers to the coexistence of obesity and sarcopenia, which imposes a heavier burden on individuals and society compared to obesity or sarcopenia alone. Therefore, comprehending the pathogenesis of SO and implementing effective clinical interventions are vital for its prevention and treatment.

Effects of high-intensity interval exercise on arterial stiffness in individuals at risk for cardiovascular disease: a meta-analysis.

Objective: The purpose of this meta-analysis was to investigate the effect of high-intensity interval training (HIIT) on arterial stiffness (AS) and vascular function in persons at high risk of cardiovascular disease (CVD).

Methods: We conducted a comprehensive search of randomized controlled trials (RCTs) published in electronic databases (PubMed, Web of Science, Cochrane, Embase, and Ebsco) since their inception through October 2023 to evaluate the effect of HIIT on AS and vascular function in persons at high risk for CVD. The weighted mean difference (WMD) and 95% confidence intervals (95% CI) were calculated, and heterogeneity was assessed using the test.

Theoretical and Experimental Investigation on the Flexural Behaviour of Prestressed NC-UHPC Composite Beams.

To investigate the normal section strength and cracking bending moment of normal concrete-ultra-high-performance concrete (NC-UHPC) composite beams, calculation formulas were established considering the tensile strength of UHPC based on the current railway bridge design code. Using the railway T-beam as a template, prestressed NC-UHPC composite beams with different NC layer heights were built. A static bending test was performed, the pressure of the steel strand and the deflection and strain of the beam were measured, and the evolution of cracks in each beam was observed.

Reduction of Infection on Wheat Through Host- and Spray-Induced Gene Silencing of an Orphan Secreted Gene.

is a soilborne fungus that can cause sharp eyespot in wheat, resulting in massive yield losses found in many countries. Due to the lack of resistant cultivars, fungicides have been widely used to control this pathogen. However, chemical control is not environmentally friendly and is costly.

PKACα negatively regulates TAK1/IRF7 signaling in black carp Mylopharyngodon piceus.

Protein Kinase A catalytic subunit α (PKACα), plays an important role in the PKA and NF-κB signaling pathway in mammals. However, the function of PKACα in teleost fish remains largely unknown. In this study, PKACα from black carp (bcPKACα) has been cloned and its role in the innate immune antiviral signaling pathway was investigated.

Black carp IKKε collaborates with IRF3 in the antiviral signaling.

Interferon regulatory factor 3 (IRF3) is activated by IκB kinase ε (IKKε) and Tank-binding kinase 1 (TBK1), which plays a crucial role in the interferon signaling in vertebrates. However, the regulation of teleost IRF3 by IKKε remains largely unknown. In this study, the IRF3 homologue (bcIRF3) of black carp (Mylopharyngodon piceus) has been cloned and characterized.

MoS nanotubes loaded with TiO nanoparticles for enhanced electrocatalytic hydrogen evolution.

Efficient and stable non-precious metal catalysts composed of earth-abundant elements are crucial to the hydrogen evolution reaction (HER) in high-energy conversion efficiency. Herein, TiO/MoS-NTs catalyst, in which the MoS nanotubes were loaded with TiO nanoparticles, have been synthesized a facile solvothermal and hydrothermal method. The as-prepared TiO/MoS-NTs electrocatalyst demonstrated enhanced electrocatalytic hydrogen evolution performance compared with MoS-NTs.