N-Demethylsinomenine Relieves Neuropathic Pain in Male Mice Mainly via Regulating α2-Subtype GABA Receptors.

Aims: N-Demethylsinomenine (NDSM) demonstrates good analgesic efficacy in preclinical pain models. However, how NDSM exerts analgesic actions remains unknown.

Methods: We examined the analgesic effects of NDSM using both pain-evoked and pain-suppressed behavioral assays in two persistent pain models.

Fructus choerospondiatis: A comprehensive review of its traditional uses, chemical composition, pharmacological activities, and clinical studies.

Ethnopharmacological Relevance: Fructus Choerospondiatis is the dried and mature fruit of Choerospondias axillaris (Roxb.) Burtt et Hill. It has been used for a long time in Tibetan and Mongolian medicine, first recorded in the ancient Tibetan medicine book "Medicine Diagnosis of the King of the Moon" in the early 8th century.

A signal recognition particle receptor gene from the sea cucumber, Apostichopus japonicas.

The signal recognition particle (SRP) system delivers approximately 30% of the proteome to the endoplasmic reticulum (ER) membrane. SRP receptor alpha (SRα) binds to SRP for targeting nascent secreted proteins to the ER membrane in eukaryotic cells. In this study, the SRα homologous gene was identified in the sea cucumber, Apostichopus japonicus (AjSRα).

Identification and functional analysis of gene and the gene in the sexual development of sea cucumber, .

Members of the Doublesex and Mab-3-related transcription factor () gene family handle various vital functions in several biological processes, including sex determination/differentiation and gonad development. and ( in invertebrates) exhibit a very conserved interaction function during testis formation in vertebrates. However, the dynamic expression pattern and functional roles of the gene family and have not yet been identified in any echinoderm species.

Sexually dimorphic expression of foxl2 in the sea urchin (Mesocentrotus nudus).

Sea urchin (Mesocentrotus nudus) is an important economically mariculture species in several Asian countries, and gonads are the sole edible parts for people. In addition to commercial value, it is an excellent model for studying gonadal development, sex determination and sex differentiation. Identify sex-related genes is an effective way to reveal the molecular mechanism of gonadal development.

Retraction Note: Modified box dimension and average weighted receiving time on the weighted fractal networks.

This paper has been retracted.

Molecular Dynamic Simulation of D-Mannitol Polymorphs in Solid State and in Solution Relating With Spontaneous Nucleation.

In this article, the polymorphic nucleation of D-mannitol was studied in depth by molecular simulating the solid state of different forms and the aqueous solution both in unsaturated and supersaturated conditions. In our previous work, it was found that different polymorphs of D-mannitol could nucleate in various supersaturations. Here in this work, we try to use molecular dynamic simulation as a tool to explore the system to microscopically understand the phenomenon.

Spectral analysis for weighted iterated q-triangulation networks.

Deterministic weighted networks have been widely used to model real-world complex systems. In this paper, we study the weighted iterated q-triangulation networks, which are generated by iteration operation F(⋅). We add q(q∈N) new nodes on each old edge and connect them with two endpoints of the old edge.

The trapping problem of the weighted scale-free treelike networks for two kinds of biased walks.

It has been recently reported that trapping problem can characterize various dynamical processes taking place on complex networks. However, most works focused on the case of binary networks, and dynamical processes on weighted networks are poorly understood. In this paper, we study two kinds of biased walks including standard weight-dependent walk and mixed weight-dependent walk on the weighted scale-free treelike networks with a trap at the central node.

Coherence analysis of a class of weighted networks.

This paper investigates consensus dynamics in a dynamical system with additive stochastic disturbances that is characterized as network coherence by using the Laplacian spectrum. We introduce a class of weighted networks based on a complete graph and investigate the first- and second-order network coherence quantifying as the sum and square sum of reciprocals of all nonzero Laplacian eigenvalues. First, the recursive relationship of its eigenvalues at two successive generations of Laplacian matrix is deduced.

Modified box dimension and average weighted receiving time on the weighted fractal networks.

In this paper a family of weighted fractal networks, in which the weights of edges have been assigned to different values with certain scale, are studied. For the case of the weighted fractal networks the definition of modified box dimension is introduced, and a rigorous proof for its existence is given. Then, the modified box dimension depending on the weighted factor and the number of copies is deduced.

Imidazolium 3-nitro-benzoate.

In the title compound, C(3)H(5)N(2) (+)·C(7)H(4)NO(4) (-), the benzene ring forms a dihedral angle of 40.60 (5)° with the imidizolium ring. The nitro-benzoate anion is approximately planar: the benzene ring makes dihedral angles of 3.

Bis(1-methyl-1-phenyl-ethyl) peroxide.

In the crystal structure, the title compound (also called dicumyl peroxide), C(18)H(22)O(2), lies on a center of symmetry. The COOC plane including the di-oxy group makes a dihedral angle of 79.10 (5)° with the phenyl ring.