Publications by authors named "Weiye Ren"
Article Synopsis
- Adaptive radiotherapy (ART) for small hepatocellular carcinoma (sHCC) faces challenges due to anatomical uncertainties and low-resolution CT scans, particularly in tumor identification and segmentation.
- The study explores using a gold nanoparticle (Au NP)-based CT contrast agent to enhance imaging for ART, showing that synthesized charged Au NPs have favorable properties like low cytotoxicity and minimal organ toxicity.
- CT images from an sHCC mouse model processed with advanced AI models (3D U-Net and 3D Trans U-Net) achieved high accuracy in tumor segmentation, indicating that charged Au NPs can significantly improve the effectiveness of ART by addressing technical issues.
The blood-brain barrier (BBB) is a complex and highly restrictive barrier that prevents most biomolecules and drugs from entering the brain. However, effective strategies for delivering drugs to the brain are urgently needed for the treatment of glioblastoma. Based on the efficient BBB penetration properties of exosomes derived from brain metastatic breast cancer cells (EB), this work prepared a nanoreactor (denoted as MAG@EB), which was constructed by self-assembly of Mn, arsenate and glucose oxidase (GOx) into nanoparticles wrapped with EB.
View Article and Find Full Text PDFPurpose: This study aims to revolutionize the treatment of aggressive triple-negative breast cancer (TNBC), notorious for its resistance to standard therapies. By ingeniously combining Tamoxifen (TMX) and Docetaxel (DTX) within a lipid-coated mesoporous silica nanoparticle (LP-MSN) delivery system, we intend to enhance therapeutic efficacy while circumventing DTX resistance mediated by CYP3A4 expression.
Methods: We rigorously tested TNBC cell lines to confirm the responsiveness to Docetaxel (DTX) and Tamoxifen (TMX).
Silencing genes using small interfering (si) RNA is a promising strategy for treating cancer. However, the curative effect of siRNA is severely constrained by low serum stability and cell membrane permeability. Therefore, improving the delivery efficiency of siRNA for cancer treatment is a research hotspot.
View Article and Find Full Text PDFBackground: Hyperglycemia-induced endothelial hyperpermeability is crucial to cardiovascular disorders and macro-vascular complications in diabetes mellitus. The objective of this study is to investigate the effects of green tea polyphenols (GTPs) on endothelial hyperpermeability and the role of nicotinamide adenine dinucleotide phosphate (NADPH) pathway.
Methods: Male Wistar rats fed on a high fat diet (HF) were treated with GTPs (0, 0.
Light alcohol consumption was reported to be negatively associated with insulin resistance and risk of cardiovascular diseases; however, the results were inconsistent. We here investigate whether long term intake of low-concentration ethanol can affect adiponectin levels. Male Wistar rats were exposed to 0.
View Article and Find Full Text PDFObjective: Hypoadiponectinemia contributes to the development of obesity and related disorders such as diabetes, hyperlipidemia, and cardiovascular diseases. In this study we investigated the effects of green tea polyphenols (GTPs) on adiponectin levels and fat deposits in high fat (HF) fed rats, the mechanism of signaling pathway was explored as well.
Methods And Results: Male Wistar rats were fed with high-fat diet.