Lack of Aquaporin 9 Reduces Brain Angiogenesis and Exaggerates Neuronal Loss in the Hippocampus Following Intracranial Hemorrhage in Mice.

Intracranial hemorrhage (ICH) is a common subtype of stroke with high morbidity and mortality. However, few clinical therapies that can reduce ICH-induced brain injury and promote the recovery outcome in ICH patients are available to improve the recovery from ICH. Given that aquaporin 9 (AQP9) plays a critical role in brain edema after ischemic stroke and traumatic brain injury and is involved in the regulation of angiogenesis, we examined the role of AQP9 in preventing neuronal loss and in neovascularization in the dorsal hippocampus (DH) after ICH.

Overexpression of interleukin-33 is associated with poor prognosis of patients with glioma.

Interleukin-33 (IL-33) has shown diagnostic and prognostic values in multiple human cancers. However, there is little knowledge on the role of IL-33 in human gliomas and its association with disease prognosis. This study aimed to evaluate the value of IL-33 in the prognosis of glioma patients.

Endoscopic expand transnasal approach to the suprasellar region: anatomical study and clinical considerations.

Background: The expanded endonasal approach (EEA) is used sparingly by surgeons for resection of lesions in the ventrocranial base. Herein, we examined the anatomy of the ventrocranial base by endoscopy and comment on the use of EEA in clinical practice.

Methods: Twenty artery-injected adult cadaveric heads were studied under surgical conditions using the endoscopic EEA.

Extended endoscopic endonasal transsphenoidal removal of tuberculum sellae meningiomas: a preliminary report.

In this present study, we reviewed our management of seven patients by an extended endoscopic endonasal transsphenoidal approach to resect tuberculum sellae meningiomas. All surgery was performed using pure endoscopy and a neuronavigation system. In six patients, total resection of the tumor was accomplished; one patient had subtotal tumor removal.