Topolectrical space-time circuits.

Topolectrical circuits have emerged as a pivotal platform for realizing static topological states that are challenging to construct in other systems, facilitating the design of robust circuit devices. In addition to spatial dimensionality, synergistic engineering of both temporal and spatial degrees in circuit networks holds tremendous potential across diverse technologies, such as wireless communications, non-reciprocal electronics and dynamic signal controls with exotic space-time topology. However, the realization of space-time modulated circuit networks is still lacking due to the necessity for flexible modulation of node connections in both spatial and temporal domains.

Non-Hermitian Global Synchronization.

Synchronization of coupled nonlinear oscillators is a prevalent phenomenon in natural systems and can play important roles in various fields of modern science, such as laser arrays and electric networks. However, achieving robust global synchronization has always been a significant challenge due to its extreme susceptibility to initial conditions and structural perturbations. Here, a novel approach is presented to achieve robust global synchronization by manipulating the interplay between non-Hermitian physics and nonlinear dynamics.

Nanoradians level high resolution autocollimation method based on array slits.

This study developed a detailed mathematical model to elucidate array slits imaging and linear CCD acquisition. Frequency domain analysis revealed the relationship between system parameters and spot image aliasing noise. Aliasing noise was reduced through optimized array slits design and linear CCD parameter selection, improving angular measurement resolution and stability.

Optical moiré bound states in the continuum.

Trapping electromagnetic waves within the radiation continuum holds significant implications in the field of optical science and technology. Photonic bound states in the continuum (BICs) present a distinctive approach for achieving this functionality, offering potential applications in laser systems, sensing technologies, and other domains. However, the simultaneous achievement of high Q-factors, flat-band dispersions, and wide-angle responses in photonic BICs has not yet been reported, thereby impeding their practical performance due to laser direction deviation or sample disorder.

High-Active Surface of Centimeter-Scale β-InS for Attomolar-Level Hg Sensing.

Recognition layer materials play a crucial role in the functionality of chemical sensors. Although advancements in two-dimensional (2D) materials have promoted sensor development, the controlled fabrication of large-scale recognition layers with highly active sites remains crucial for enhancing sensor sensitivity, especially for trace detection applications. Herein, we propose a strategy for the controlled preparation of centimeter-scale non-layered ultrathin β-InS materials with tailored high-active sites to design ultrasensitive Hg sensors.

Heterostructured n-ZnO@p-CuO nanosheets filled in a polymer matrix for enhanced electrostatic energy storage performance.

Metallized film capacitors use plastic films as the dielectric spacer, and these polymer films generally have low dielectric constants. To boost the electrostatic energy storage density of a film capacitor, advanced high- films with high electrical breakdown strength and low dielectric loss are highly desired. Herein, polymer nanocomposite films were made by filling ZnO@CuO nanosheets into poly(vinylidene fluoride--hexafluoropropylene) [P(VDF-HFP)].

Poly(ether imide) Film Doped with Protonated Tetra(aniline) Molecules for Efficiently Enhancing the Capacitive Energy Storage Performance.

The polymer dielectric spacer plays a key role in the performance of film capacitors. However, currently, commercial polymer dielectric films generally have low relative dielectric constants (<4) and low capacitive energy storage densities (<3 J cm). Here, we report the use of protonated tetra(aniline) (TANI) molecules with a length of 1.

Large-Scale Synthesis of High-Loading Single Metallic Atom Catalysts by a Metal Coordination Route.

Single atom catalyst (SAC) is one of the most efficient and versatile catalysts with well-defined active sites. However, its facile and large-scale preparation, the prerequisite of industrial applications, has been very challenging. This dilemma originates from the Gibbs-Thomson effect, which renders it rather difficult to achieve high single atom loading (< 3 mol%).

Reversal of tamoxifen resistance by artemisinin in ER+ breast cancer: bioinformatics analysis and experimental validation.

Breast cancer is the leading cause of cancer-related deaths in women worldwide, with Hormone Receptor (HR)+ being the predominant subtype. Tamoxifen (TAM) serves as the primary treatment for HR+ breast cancer. However, drug resistance often leads to recurrence, underscoring the need to develop new therapies to enhance patient quality of life and reduce recurrence rates.

Topologically Protected Quantum Logic Gates with Valley-Hall Photonic Crystals.

Topological photonics provide a promising way to realize more robust optical devices against some defects and environmental perturbations. Quantum logic gates are fundamental units of quantum computers, which are widely used in future quantum information processing. Thus, constructing robust universal quantum logic gates is an important way forward to practical quantum computing.

An exosome-derived lncRNA signature identified by machine learning associated with prognosis and biomarkers for immunotherapy in ovarian cancer.

Background: Ovarian cancer (OC) has the highest mortality rate among gynecological malignancies. Current treatment options are limited and ineffective, prompting the discovery of reliable biomarkers. Exosome lncRNAs, carrying genetic information, are promising new markers.

Hyperbolic photonic topological insulators.

Topological photonics provides a new degree of freedom to robustly control electromagnetic fields. To date, most of established topological states in photonics have been employed in Euclidean space. Motivated by unique properties of hyperbolic lattices, which are regular tessellations in non-Euclidean space with a constant negative curvature, the boundary-dominated hyperbolic topological states have been proposed.

Non-Abelian Topological Bound States in the Continuum.

Bound states in the continuum (BICs), which are spatially localized states with energies lying in the continuum of extended modes, have been widely investigated in both quantum and classical systems. Recently, the combination of topological band theory with BICs has led to the creation of topological BICs that exhibit extraordinary robustness against disorder. However, the previously proposed topological BICs are only limited in systems with Abelian gauge fields.

CRP, IL-1α, IL-1β, and IL-6 levels and the risk of breast cancer: a two-sample Mendelian randomization study.

Epidemiological studies have reported a positive association between chronic inflammation and cancer risk. However, the causal association between chronic inflammation and breast cancer (BC) risk remains unclear. Here, we performed a Mendelian randomization study to investigate the etiological role of chronic inflammation in BC risk.

Integrated analysis of single-cell RNA-seq and bulk RNA-seq unravels the heterogeneity of cancer-associated fibroblasts in TNBC.

Background: The treatment of triple-negative breast cancer (TNBC) is one of the main focuses and key difficulties because of its heterogeneity, and the source of this heterogeneity is unclear.

Methods: Single-cell RNA (scRNA) and transcriptomics data of TNBC and normal breast samples were retrieved from Gene Expression Omnibus (GEO) database and TCGA-BRCA database. These cells were clustered using the t-SNE and UMAP method, and the marker genes for each cluster were found.

Severe mental illness and the risk of breast cancer: A two-sample, two-step multivariable Mendelian randomization study.

Background: Based on epidemiological reports, severe mental illness (SMI) and breast cancer (BC) risk are linked positively. However, it is susceptible to clinical confounding factors, such as smoking, alcohol consumption, etc. Here, we performed a two-sample, two-step multivariable Mendelian randomization (MR) research to explore how the SMI etiologically influences BC risk and to quantify mediating effects of known modifiable risk factors.

Non-Abelian Inverse Anderson Transitions.

Inverse Anderson transitions, where the flat-band localization is destroyed by disorder, have been wildly investigated in quantum and classical systems in the presence of Abelian gauge fields. Here, we report the first investigation on inverse Anderson transitions in the system with non-Abelian gauge fields. It is found that pseudospin-dependent localized and delocalized eigenstates coexist in the disordered non-Abelian Aharonov-Bohm cage, making inverse Anderson transitions depend on the relative phase of two internal pseudospins.

Super-compact universal quantum logic gates with inverse-designed elements.

Integrated quantum photonic circuit is a promising platform for the realization of quantum information processing in the future. To achieve the large-scale quantum photonic circuits, the applied quantum logic gates should be as small as possible for the high-density integration on chips. Here, we report the implementation of super-compact universal quantum logic gates on silicon chips by the method of inverse design.

Comprehensive analysis of a cuproptosis-related ceRNA network implicates a potential endocrine therapy resistance mechanism in ER-positive breast cancer.

Background: While adjuvant endocrine therapy (ET) may decrease the mortality rate of estrogen receptor-positive (ER+) breast cancer (BC), the likelihood of relapse and metastasis due to ET resistance remains high. Cuproptosis is a recently discovered regulated cell death (RCD), whose role in tumors has yet to be elucidated. Thus, there is a need to study its specific regulatory mechanism in resistance to ET in BC, to identify novel therapeutic targets.

Effect of ERCC1 polymorphisms on the response to platinum-based chemotherapy: A systematic review and meta-analysis based on Asian population.

Background: Platinum-based chemotherapy is one of the most common treatments for many cancers; however, the effect of chemotherapy varies from individual to individual. Excision repair cross complementation group 1 (ERCC1) is widely recognized as a key gene regulating nucleotide excision repair (NER) and is closely associated with platinum response. Many studies have yielded conflicting results regarding whether ERCC1 polymorphisms can affect the response to platinum and overall survival (OS).

Non-Hermitian Topolectrical Circuit Sensor with High Sensitivity.

Electronic sensors play important roles in various applications, such as industry and environmental monitoring, biomedical sample ingredient analysis, wireless networks and so on. However, the sensitivity and robustness of current schemes are often limited by the low quality-factors of resonators and fabrication disorders. Hence, exploring new mechanisms of the electronic sensor with a high-level sensitivity and a strong robustness is of great significance.

Remote Sensing Image of The Landsat 8-9 Compressive Sensing via Non-Local Low-Rank Regularization with the Laplace Function.

Utilizing low-rank prior data in compressed sensing (CS) schemes for Landsat 8-9 remote sensing images (RSIs) has recently received widespread attention. Nevertheless, most CS algorithms focus on the sparsity of an RSI and ignore its low-rank (LR) nature. Therefore, this paper proposes a new CS reconstruction algorithm for Landsat 8-9 remote sensing images based on a non-local optimization framework (NLOF) that is combined with non-convex Laplace functions (NCLF) used for the low-rank approximation (LAA).

Hyperbolic band topology with non-trivial second Chern numbers.

Topological band theory establishes a standardized framework for classifying different types of topological matters. Recent investigations have shown that hyperbolic lattices in non-Euclidean space can also be characterized by hyperbolic Bloch theorem. This theory promotes the investigation of hyperbolic band topology, where hyperbolic topological band insulators protected by first Chern numbers have been proposed.