Bioequivalence Study of Atenolol Tablets in Healthy Chinese Subjects Under Fasting and Fed Conditions.

Atenolol, a cardioselective β1-blocker, exhibits efficacy in treating cardiovascular diseases. We conducted a single-center, randomized, open, single-dose, 2-preparation, 2-cycle, 2-sequence, double-crossover trial with a 7-day washout period to investigate the pharmacokinetics, bioequivalence (BE), and safety of test and reference atenolol tablets (25 mg) in healthy Chinese volunteers. Forty-eight healthy participants were randomized into the fasting and fed arms.

Stability evaluation of rock pillar between twin tunnels using the YAI.

The stability of rock pillar is crucial for ensuring the construction safety of twin tunnels with small clearance, especially when transitioning from the traditional left-right tunnel layouts to the up-down configurations due to complex and variable site constraints. However, there are limited researches on the evaluation and comparative study of the stability of these two types of rock pillars in twin tunnels. This paper introduces the yield approach index (YAI) as a measure to assess the stability of rock pillar in twin tunnels with small clearance, and various influencing factors including side pressure coefficient (SPC), stress release rate (SRR), and the thickness of rock pillar (characterised by the ratio of rock pillar thickness to tunnel diameter, RPT/TD) are considered in the analysis.

Pharmacokinetics, Bioequivalence, and Safety Evaluation of 2 Formulations of 10-mg Rivaroxaban Tablets: A 4-Period Crossover Trial.

This study compared the safety, bioequivalence, and pharmacokinetic properties of 2 formulations of 10-mg rivaroxaban tablets in healthy Chinese participants in fasting and fed arms. The trial was an open, randomized, 4-period, replicated crossover scheme, and 36 volunteers were recruited separately for the fasting and fed arms. Volunteers were randomly administered a single dose of the test or reference formulation (10 mg) orally, followed by a 5-day washout period.

A new force-measuring balance for large-scale model in hypersonic wind tunnel.

There is a strong coupling effect between the body and propulsion system of the integrated hypersonic vehicle. The scaled-down model cannot reflect the laws of physics. Therefore, carrying out hypersonic aerodynamic tests using large-scale aircraft models is an urgent difficulty and the key link in the research of hypersonic aircraft.

gen. nov., sp. nov. isolated from Antarctic intertidal sediment, transfer of to gen. nov. as comb. nov.

A Gram-stain-negative, aerobic, non-flagellated and rod- or ovoid-shaped bacterium, designated as strain S4J41, was isolated from Antarctic intertidal sediment. The isolate grew at 0-37 °C and with 0.5-10 % (w/v) NaCl.

Synthesis and Evaluation of Novel Ligustrazine Derivatives as Multi-Targeted Inhibitors for the Treatment of Alzheimer's Disease.

A series of novel ligustrazine derivatives ⁻ were designed, synthesized, and evaluated as multi-targeted inhibitors for anti-Alzheimer's disease (AD) drug discovery. The results showed that most of them exhibited a potent ability to inhibit both ChEs, with a high selectivity towards AChE. In particular, compounds and had the greatest inhibitory abilities for AChE, with IC values of 1.