Publications by authors named "Weixin Han"
Article Synopsis
- Lambert-Eaton myasthenic syndrome (LEMS) is a rare neurological condition affecting muscle transmission, often slowly progressing and can be misdiagnosed initially.
- The diagnosis of LEMS can be supported by testing for SOX-1 antibodies, which are highly specific to small cell lung cancer (SCLC).
- A case study of a 56-year-old man revealed that even after initial scans showed no tumors, SCLC was eventually detected 10 months later, highlighting the need for ongoing monitoring in LEMS patients with positive SOX-1 antibodies.
Objective: To investigate the clinical efficacy and safety of different doses of intrathecal methotrexate in the treatment of leptomeningeal carcinomatosis.
Methods: 53 patients admitted to the Second Hospital of Hebei Medical University with leptomeningeal carcinomatosis were recruited. They were divided into two groups: 15-mg-group received 15 mg methotrexate intrathecally, while the other received 10 mg methotrexate.
Background: It is usually very complicated to treat meningeal carcinomatosis, and it is important to treat it as soon as possible.
Case Presentation: The 19-Del mutation was found in the exon for the epidermal growth factor receptor gene in the pleural effusion of a patient on March 11th, 2015. He took 250 mg of oral gefitinib once a day for 11 months beginning in December of 2015.
Clinical outcome and prognostic analysis of meningeal carcinomatosis treated by intrathecal chemotherapy.
Expert Rev Pharmacoecon Outcomes Res
August 2018
Objective: To evaluate the clinical efficacy of meningeal carcinomatosis (MC) treated by intrathecal chemotherapy (IC) and analyzes the prognostic factors.
Methods: The clinical and follow-up data of 33 MC patients was collected and retrospectively analyzed. Potential prognostic factors such as age, gender, primary cancer, transfer time, presence of brain metastasis, intracranial pressure, protein, glucose, vascular endothelial growth factor (VEGF), eastern cooperative oncology group (ECOG) performance status (PS), systemic treatment and IC were discussed.
Article Synopsis
- This study reports on 11 patients diagnosed with anti-GABAB receptor encephalitis in China, detailing their clinical features, laboratory results, imaging findings, treatments, and outcomes.
- Most patients experienced significant cognitive decline, epilepsy, and various other neurological symptoms, with small-cell lung cancer detected in 5 of them.
- While most patients had a good response to first-line immune therapy, outcomes varied, particularly for those with associated tumors, highlighting the importance of early treatment.