Robust MnO-WO Complementary Electrochromic Device Enabled by Reversible Electrodeposition of MnO.

Reversible electrodeposition and dissolution of manganese oxide (MnO) represent an emerging electrochromic system. However, challenges such as "dead MnO" formation, limited optical modulation across a narrow wavelength range, and difficulties in scaling up have significantly hindered the development of MnO reversible electrodeposition-based electrochromic windows. In this work, we introduced Fe/Fe mediator ions into the electrolyte to suppress the Jahn-Teller effect, thereby preventing the formation of "dead MnO" and achieving stable and reversible MnO deposition/dissolution.

Exposure to air pollution and non-neoplastic digestive system diseases: findings from the China health and retirement longitudinal study.

Objectives: Increasing concern about air pollution's impact on public health underscores the need to understand its effects on non-neoplastic digestive system diseases (NNDSD). This study explores the link between air pollution and NNDSD in China.

Methods: We conducted a national cross-sectional study using 2015 data from the China Health and Retirement Longitudinal Study (CHARLS), involving 13,046 Chinese adults aged 45 and above from 28 provinces.

Multiplexed immunosensing of cancer biomarkers on a split-float-gate graphene transistor microfluidic biochip.

This work reports the development of a novel microfluidic biosensor using a graphene field-effect transistor (GFET) design for the parallel label-free analysis of multiple biomarkers. Overcoming the persistent challenge of constructing μm-sized FET sensitive interfaces that incorporate multiple receptors, we implement a split-float-gate structure that enables the manipulation of multiplexed biochemical functionalization using microfluidic channels. Immunoaffinity biosensing experiments are conducted using the mixture samples containing three liver cancer biomarkers, carcinoembryonic antigen (CEA), α-fetoprotein (AFP), and parathyroid hormone (PTH).

Nonlocal Optical Response of Particle Plasmons in Single Gold Nanorods.

The investigation of particle plasmons in metal nanoparticles has predominantly relied on local optical response approximations. However, as the nanoparticle size approaches the average distance of electrons to the metal surface, mesoscopic effects such as size-dependent plasmon line width broadening and resonance energy blue shifts are expected to become observable. In this work, we compared the experimental spectral characteristics with simulated values obtained by using a generalized nonlocal optical response theory-based local analogue model.

Multiple solution solving in plasmon sensing by deep learning: determination of layer refractive index and thickness in one experiment: comment.

In a recent Letter [Opt. Lett.46, 5667 (2021)10.

Perivascular epithelioid cell tumors of the liver misdiagnosed as hepatocellular carcinoma: Three case reports.

Background: Hepatic perivascular epithelioid cell neoplasms (PEComas) are rare. Diagnostic and treatment experience with hepatic PEComa remains insufficient.

Case Summary: Three hepatic PEComa cases are reported in this paper: One case of primary malignant hepatic PEComa, one case of benign hepatic PEComa, and one case of hepatic PEComa with an ovarian mature cystic teratoma.

Impact of shift work on irritable bowel syndrome and functional dyspepsia: A meta-analysis.

Background: The possible association between shift work with irritable bowel syndrome (IBS) and functional dyspepsia (FD) remains controversial. The purpose of the study is to conduct a meta-analysis to explore the potential association between shift work with IBS/FD.

Methods: We searched relevant observational studies on Medline (PubMed) and Embase until June 30, 2021.

Obeticholic Acid Induces Hepatoxicity Via FXR in the NAFLD Mice.

Obeticholic acid (OCA), a potent farnesoid X receptor (FXR) agonist, is a promising drug for nonalcoholic fatty liver disease (NAFLD); however, it can cause liver injury, especially at high doses. Here, we investigated the role of FXR in the high-dose OCA-induced hepatoxicity in the condition of the NAFLD mouse model. Wild-type (WT) mice and FXR mice were administered with over-dose OCA (0.

Obeticholic acid inhibits hepatic fatty acid uptake independent of FXR in mouse.

Objective: Obeticholic acid (OCA), a farnesoid X receptor (FXR) agonist, is believed to alleviate nonalcoholic fatty liver disease (NAFLD) by decreasing hepatic lipogenesis in an FXR-dependent manner. Here, we revealed a novel mechanism by which OCA improves NAFLD by affecting hepatic long-chain fatty acids (LCFAs) uptake.

Methods: Stably transfected HEK-293 cells expressing fatty acid transport protein 5 (FATP5) were established to examine fatty acid uptake; FXR, human (h) FATP5, and FXR/hFATP5 mouse models were incorporated to explore the effects of OCA on FATP5 ex vivo and in vivo.

Steering the Pathway of Plasmon-Enhanced Photoelectrochemical CO Reduction by Bridging Si and Au Nanoparticles through a TiO Interlayer.

Photoelectrochemical (PEC) conversion of CO in an aqueous medium into high-energy fuels is a creative strategy for storing solar energy and closing the anthropogenic carbon cycle. However, the rational design of catalytic architectures to selectively and efficiently produce a target product such as CO has remained a grand challenge. Herein, an efficient and selective Si photocathode for CO production is reported by utilizing a TiO interlayer to bridge the Au nanoparticles and n p-Si.

Single-particle spectroscopic investigation on the scattering spectrum of Au@MoS core-shell nanosphere heterostructure.

Owing to the uniform shape of the nanospheres, the Au@MoS core-shell nanosphere heterostructure enables us to design nano-optoelectronic devices and nanosensors with highly tunable and reproducible optical properties. However, until now, at the single-particle level, there is still uncertainty as to how much the scattering characteristics depend on the particle size and the local environment. In this letter, we performed an single-particle study of the scattering spectrum of the Au@MoS core-shell nanosphere heterostructure before and after coating with the MoS layer.

Revisiting the plasmon radiation damping of gold nanorods.

Noble metal nanoparticles have been utilized for a vast amount of optical applications. For applications that use metal nanoparticles as nanosensors and for optical labeling, higher radiative efficiency is preferred. To get a deeper knowledge about the radiation damping of noble metal nanoparticles, we used gold nanorods with different geometry factors (aspect ratios) as the model system to study.

Observing Mesoscopic Nucleic Acid Capacitance Effect and Mismatch Impact via Graphene Transistors.

This work reports a molecular-scale capacitance effect of the double helical nucleic acid duplex structure for the first time. By quantitatively conducting large sample measurements of the electrostatic field effect using a type of high-accuracy graphene transistor biosensor, an unusual charge-transport behavior is observed in which the end-immobilized nucleic acid duplexes can store a part of ionization electrons like molecular capacitors, other than electric conductors. To elucidate this discovery, a cascaded capacitive network model is proposed as a novel equivalent circuit of nucleic acid duplexes, expanding the point-charge approximation model, by which the partial charge-transport observation is reasonably attributed to an electron-redistribution behavior within the capacitive network.

Multiplexed detection of heavy metal ions by single plasmonic nanosensors.

Detection of multiple analytes simultaneously in small liquid samples with high efficiency and precision is highly important to the fields like water quality monitoring. In this letter, we present a multiplexed nanosensors with position-encoded aptamer functionalized gold nanorods for heavy metal ions detection. The individual gold nanorods respond specifically to two different heavy metal ions (Pb and Hg) with a spectral shift in the scattering spectrum.

4.9% Au stabilizes Ag in an atomically homogenous bimetallic alloy for anisotropic nanocrystals with enhanced stability under light irradiation.

Instability problems encountered by Ag nanocrystals largely limit their use in practical applications. In AuAg bimetallic alloys, the stability of Ag can be greatly enhanced, whereas doping a high fraction of Au to the alloy usually leads to the loss of the superior properties of Ag and undesirable degradation of the quality factor of the plasmonic resonance. Herein, we provide experimental evidence that the atomically homogenous AuAg alloy nanocrystals with Au fraction as low as 4.

Warhead Reactivity Limits the Speed of Inhibition of the Cysteine Protease Rhodesain.

Viral and parasitic pathogens rely critically on cysteine proteases for host invasion, replication, and infectivity. Their inhibition by synthetic inhibitors, such as vinyl sulfone compounds, has emerged as a promising treatment strategy. However, the individual reaction steps of protease inhibition are not fully understood.

Intensity-Based Single Particle Plasmon Sensing.

Plasmon sensors respond to local changes of their surrounding environment with a shift in their resonance wavelength. This response is usually detected by measuring light scattering spectra to determine the resonance wavelength. However, single wavelength detection has become increasingly important because it simplifies the setup, increases speed, and improves statistics.

Single Out-of-Resonance Dielectric Nanoparticles as Molecular Sensors.

Light scattering from single nanoparticles and nanostructures is a commonly used readout method for nanosensors. Increasing the spectral sensitivity of resonant nanosensors to changes in their local surrounding has been the focus of many studies. Switching from spectral to intensity monitoring allows one to investigate nonresonant or out-of-resonance dielectric nanoparticles.

Plasmonic Nanosensors for the Label-Free Imaging of Dynamic Protein Patterns.

We introduce a new approach to monitor the dynamics and spatial patterns of biological molecular assemblies. Our molecular imaging method relies on plasmonic gold nanoparticles as point-like detectors and requires no labeling of the molecules. We show spatial resolution of up to 5 μm and 30 ms temporal resolution, which is comparable to wide-field fluorescence microscopy, while requiring only readily available gold nanoparticles and a dark-field optical microscope.

In situ monitoring of silver adsorption on assembled gold nanorods by surface-enhanced Raman scattering.

Self-assembly of metal nanocrystals is able to create a gap of sub-nanometer distance for concentrating incoming light by the strong coupling of surface plasmon resonance, known as a 'hot spot'. Although the plasmonic property of silver is better than other metals in the visible range, the superior Raman enhancement of silver compared to gold is still under debate. To provide direct evidence, in this work, we studied the silver adsorption on assembled gold nanorods (AuNRs) using in situ surface-enhanced Raman scattering (SERS) measurements.

Plasmonic thermochromism based on a reversible redox reaction of Ag/Ag on Au nanorods.

Reversible redox reaction-based thermochromism using plasmonic nanocrystals is challenging due to the requirements set based on the complexity of the reaction system where the oxidizing and reducing agents must not interfere with each other, and both should possess temperature sensitivity. Herein, we demonstrate plasmonic thermochromism based on a reversible redox reaction of Ag+/Ag on Au nanorods (AuNRs) by incorporating temperature-sensitive reducing and oxidizing agents into the same system. The competition between reduction and oxidation is solely dependent on temperature.

Mapping Hot Electron Response of Individual Gold Nanocrystals on a TiO Photoanode.

Incorporating metal nanocrystals with semiconductor photoanodes significantly enhances the efficiency of the energy conversion in the visible range during water splitting due to the excitation of hot electrons. While extensively studied on ensemble samples, hot electron response of metal nanocrystals in a photoelectrochemical cell remains unexploited at the single-particle level. Herein, we systematically investigate hot electron response of individual single-crystalline gold nanocrystals (AuNCs) on a TiO photoanode during water splitting.

Fully Solid-State Graphene Transistors with Striking Homogeneity and Sensitivity for the Practicalization of Single-Device Electronic Bioassays.

To break through a critical barrier in the practical application of graphene biosensors, namely, device-to-device performance inhomogeneity, this work presents a novel scenario employing a fully solid-state (FSS) transistor configuration. Herein, the graphene sensing unit is completely encapsulated by a high-κ solid dielectric material, which isolates the sensing unit from solution contaminants and thus homogeneously maintains the extraordinary carrier mobility of pristine graphene in batch-made devices. To create an interface sensitive to biomolecular interactions based on the FSS configuration, a metallic floating gate functionalized by conductive mercapto-phenyl molecular linkers is defined on the top-layer solid dielectric.