Association between TRMT61B gene polymorphism and Wilms tumor susceptibility in Chinese children.

Background: Wilms tumor is among the most common pediatric malignant tumors. Although mA modification influences the structure and function of RNA and participates in tumorigenesis, the relationship between mA methyltransferase TRMT61B gene polymorphisms and Wilms tumor susceptibility is unclear.

Methods: We examined the relationship between TRMT61B gene rs4563180 G > C polymorphism (detected by TaqMan probe method) in 414 children with Wilms tumor and 1199 healthy controls.