Porcine Epidemic Diarrhea Virus Antagonizes Host IFN-λ-Mediated Responses by Tilting Transcription Factor STAT1 toward Acetylation over Phosphorylation To Block Its Activation.

Porcine epidemic diarrhea virus (PEDV) is the main etiologic agent causing acute swine epidemic diarrhea, leading to severe economic losses to the pig industry. PEDV has evolved to deploy complicated antagonistic strategies to escape from host antiviral innate immunity. Our previous study demonstrated that PEDV downregulates histone deacetylase 1 (HDAC1) expression by binding viral nucleocapsid (N) protein to the transcription factor Sp1, inducing enhanced protein acetylation.

The dynamics of social support and affective well-being before and during COVID: An experience sampling study.

Based on the dynamic motivational activation (DMA) theoretical framework, this study examines the dynamic, reciprocal relationship between social support and affective well-being in both face-to-face (F2F) and online channels before and during the COVID-19 pandemic. Using experience sampling method, 2002 surveys on F2F and online interactions were collected from 64 participants. Dynamic panel modeling results showed that emotional support was associated with lower emotional discomfort toward F2F and online social interactions.

"Was it something I said?" "No, it was something you posted!" A study of the spiral of silence theory in social media contexts.

New media technologies make it necessary for scholars to reassess mass communication theories developed among legacy media. One such theory is the spiral of silence theory originally proposed by Noelle-Neumann in the 1970s. Increasing diversity of media content, selectivity, social networking site (SNS) interactivity, and the potential for anonymity have posed various challenges to its theoretical assumptions.