Construction of bFGF/heparin and FeO nanoparticles functionalized scaffolds aiming at vascular repair and magnetic resonance imaging monitoring.

This work develops a bioactive basic fibroblast growth factor (bFGF)/heparin and FeO nanoparticles (NPs) trifunctionalized degradable construct with the potential of using as a vascular tissue engineering scaffold with the aim of improving vascular repair and regeneration therapy. The covalent modification of heparin onto the poly(lactic acid) (PLA)-gelatin (Gel)-FeO (PGF) scaffold improves the hydrophilicity of the scaffold. Furthermore, the electrostatic adsorption of bFGF on heparin allows for a more consistent and prolonged release of bFGF in situ, hence increasing the stability and effectiveness of bFGF around the surrounding vascular tissues.

Customized Vascular Repair Microenvironment: Poly(lactic acid)-Gelatin Nanofibrous Scaffold Decorated with bFGF and Ag@FeO Core-Shell Nanowires.

Vascular defects caused by trauma or vascular diseases can significantly impact normal blood circulation, resulting in serious health complications. Vascular grafts have evolved as a popular approach for vascular reconstruction with promising outcomes. However, four of the greatest challenges for successful application of small-diameter vascular grafts are (1) postoperative anti-infection, (2) preventing thrombosis formation, (3) utilizing the inflammatory response to the graft to induce tissue regeneration and repair, and (4) noninvasive monitoring of the scaffold and integration.

Asymmetric Low-Frequency Pulsed Strategy Enables Ultralong CO Reduction Stability and Controllable Product Selectivity.

Copper-based catalysts are widely explored in electrochemical CO reduction (CORR) because of their ability to convert CO into high-value-added multicarbon products. However, the poor stability and low selectivity limit the practical applications of these catalysts. Here, we proposed a simple and efficient asymmetric low-frequency pulsed strategy (ALPS) to significantly enhance the stability and the selectivity of the Cu-dimethylpyrazole complex Cu(DMPz) catalyst in CORR.

Indium-Based Metal-Organic Framework for High-Performance Electroreduction of CO to Formate.

It is urgent to find a catalyst with high selectivity and efficiency for the reduction of CO by renewable electric energy, which is the important means to reduce the greenhouse effect. In this work, we report that the metal-organic framework (MOF) indium-based 1,4-benzenedicarboxylate (In-BDC) catalyzes CO to formate with a Faradaic efficiency (FE) of more than 80% in a wide voltage range between -0.419 and -0.

Ultrathin 2D nickel zeolitic imidazolate framework nanosheets for electrocatalytic reduction of CO.

Ultrathin 2D nickel(II) (Ni2+) and imidazole (Im) based zeolitic imidazolate framework Ni(Im)2 nanosheets are reported as exceptional efficient electrocatalysts for the electrocatalytic CO2 reduction reaction. Five nanometre thick nanosheets have a higher faradaic efficiency of 78.8% and a surface active site density of 1.

Visible-Light-Mediated Decarboxylative Alkylation Cascade Cyano Insertion/Cyclization of N-Arylacrylamides under Transition-Metal-Free Conditions.

The visible-light-mediated decarboxylative functionalization of aliphatic carboxylic acids using organocatalysts has rarely been reported. This study represented an environmentally benign decarboxylation method involving the combination of eosin Y and (NH)SO. This system converted aliphatic carboxylic acids to alkyl radicals, followed by their addition to the carbon-carbon double bond of the N-arylacrylamide cascade cyano insertion/cyclization to construct alkylated phenanthridines in moderate to good yields under photoredox catalysis.

Radical Addition/Insertion/Cyclization Cascade Reaction To Assemble Phenanthridines from N-Arylacrylamide Using Cyano as a Bridge under Photoredox Catalysis.

A radical addition/nitrile insertion/homolytic aromatic substitution (HAS) cascade reaction to prepare 6-quaternary alkylated phenanthridines was developed. The addition of the active methylene radicals which were generated from 2-bromoacetonitrile, ethyl 2-bromoacetate, 2-bromo-N,N-dimethylacetamide, or 2-bromo-1-phenylethan-1-one to carbon-carbon double bonds of N-arylacrylamides followed by the cyano-participating sequential cyclization produced a series of phenanthridines in moderate to good yields under photoredox catalysis.