Publications by authors named "Weiwen Wu"

Background: Numerous studies have pointed out the benefits of family meetings, but it is unclear who uses family meetings and what the effects are on use of the end-of-life care.

Aim: The purposes of this study were to explore which characteristics are associated with the use of the family meeting and what effects the family meeting has on end-of-life care.

Design: A retrospective observational study using 2012-2017 data from Taiwan's National Health Insurance claims database, cancer registry, and death registry.

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Low-dose digital radiography (DR) and computed tomography (CT) become increasingly popular due to reduced radiation dose. However, they often result in degraded images with lower signal-to-noise ratios, creating an urgent need for effective denoising techniques. The recent advancement of the single-image-based denoising approach provides a promising solution without requirement of pairwise training data, which are scarce in medical imaging.

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Article Synopsis
  • The study focuses on improving the diagnosis of functional brain diseases using functional brain networks (FBNs) analyzed through resting-state fMRI, addressing key limitations in current methodologies.
  • It critiques existing methods for only measuring synchronous functional connectivities (FCs) among brain regions, proposing a new sliding-window approach that models asynchronous FCs, acknowledging the time gaps in information flow.
  • The authors also introduce a framework for joint modeling of common and individual FBNs, enhancing diagnostic accuracy by reducing variability and allowing for end-to-end analysis tailored for diseases like mild cognitive impairment (MCI).
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  • MRI is a crucial diagnostic tool, but long scanning times can negatively impact patient comfort and image quality during various scan types.
  • Recent advancements in MRI acceleration involve innovative techniques like algorithm unrolling, enhancement methods, and generative models, which help improve scanning efficiency and outcomes.
  • The review highlights the integration of data with physics-based models and addresses challenges like image redundancy and model generalization, proposing future research directions focusing on data harmonization and federated learning for better MRI reconstruction.
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Background: A significant number of coronavirus disease 2019 (COVID-19) survivors are experiencing long COVID, with symptoms lasting beyond three months. While diverse long COVID symptoms are established, there are gaps in understanding its long-term trends, intensity, and risk factors, requiring further investigation.

Aims: This study aimed to investigate the long COVID characteristics and associated factors by following COVID-19 survivors for one year post-infection and comparing them with healthy counterparts.

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Deep learning has been extensively applied in medical image reconstruction, where Convolutional Neural Networks (CNNs) and Vision Transformers (ViTs) represent the predominant paradigms, each possessing distinct advantages and inherent limitations: CNNs exhibit linear complexity with local sensitivity, whereas ViTs demonstrate quadratic complexity with global sensitivity. The emerging Mamba has shown superiority in learning visual representation, which combines the advantages of linear scalability and global sensitivity. In this study, we introduce MambaMIR, an Arbitrary-Masked Mamba-based model with wavelet decomposition for joint medical image reconstruction and uncertainty estimation.

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  • Computed tomography (CT) denoising is difficult due to the lack of noisy-clean image pairs in clinical contexts, which makes supervised learning challenging.
  • The study introduces the Residual Image Prior Network (RIP-Net) to overcome limitations of existing self-supervised methods by modeling residuals between similar noisy images and includes a new regularization term for better performance.
  • Through experiments on various CT datasets, RIP-Net shows improved accuracy and robustness over other unsupervised denoising methods by effectively learning high and low-frequency features and capturing contextual information.
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The multi-source stationary CT, where both the detector and X-ray source are fixed, represents a novel imaging system with high temporal resolution that has garnered significant interest. Limited space within the system restricts the number of X-ray sources, leading to sparse-view CT imaging challenges. Recent diffusion models for reconstructing sparse-view CT have generally focused separately on sinogram or image domains.

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Article Synopsis
  • The study introduces a rapid-sampling strategy called the time-reversion fast-sampling (TIFA) model for improving image reconstruction in limited-angle computed tomography (LACT) using score-based generative models (SGM).
  • Traditional SGM methods are computationally intensive, requiring many sampling steps, but TIFA significantly reduces this by utilizing a combination of jump sampling, time-reversion, and compressed sampling.
  • Experimental results show that TIFA achieves high-quality image reconstruction using only 200 sampling steps, outperforming other leading methods that require 2000 steps, and can still produce quality images with as few as 10 steps.
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Metal artifact reduction (MAR) is important for clinical diagnosis with CT images. The existing state-of-the-art deep learning methods usually suppress metal artifacts in sinogram or image domains or both. However, their performance is limited by the inherent characteristics of the two domains, i.

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Recent research has indicated that attractive faces often cause a dilation of our time perception thus affecting physical and mental health, and speculates that this could be relevant to the fact that attractive faces capture people's attention. Nevertheless, there was no direct experimental data to support this speculation. The present work was designed to illustrate how attention affects time perception of facial attractiveness.

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Analyzing functional brain networks (FBN) with deep learning has demonstrated great potential for brain disorder diagnosis. The conventional construction of FBN is typically conducted at a single scale with a predefined brain region atlas. However, numerous studies have identified that the structure and function of the brain are hierarchically organized in nature.

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  • Score-based generative models (SGM) are becoming popular for sparse-view CT reconstruction due to their strong image generation capabilities, but current methods face issues with data consistency, artifact generation, and reliance on intermediate results instead of ground truth.
  • In response, the Multi-channel Optimization Generative Model (MOGM) improves reconstruction by incorporating a new data consistency term into the model, relying only on original data to enhance outcome stability.
  • Testing on 23 view datasets from both numerical simulations and real clinical cases shows MOGM significantly outperforms existing methods, effectively reconstructing images from as few as 10 and 7 views.
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  • Computed Tomography (CT) is commonly used for non-destructive testing, but achieving high-resolution images of large objects remains challenging due to technical limitations.
  • The study introduces a deep learning method called SPEAR (spectrum learning) network that enhances CT image resolution by integrating both global and high-frequency information for better detail preservation.
  • Experimental results indicate that the SPEAR network outperforms current methods, effectively producing high-quality images even from low-resolution and low-dose inputs, thus holding promise for various industrial applications.
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Score-based generative model (SGM) has demonstrated great potential in the challenging limited-angle CT (LA-CT) reconstruction. SGM essentially models the probability density of the ground truth data and generates reconstruction results by sampling from it. Nevertheless, direct application of the existing SGM methods to LA-CT suffers multiple limitations.

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Diffusion model has emerged as a potential tool to tackle the challenge of sparse-view CT reconstruction, displaying superior performance compared to conventional methods. Nevertheless, these prevailing diffusion models predominantly focus on the sinogram or image domains, which can lead to instability during model training, potentially culminating in convergence towards local minimal solutions. The wavelet transform serves to disentangle image contents and features into distinct frequency-component bands at varying scales, adeptly capturing diverse directional structures.

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Limited-angle tomographic reconstruction is one of the typical ill-posed inverse problems, leading to edge divergence with degraded image quality. Recently, deep learning has been introduced into image reconstruction and achieved great results. However, existing deep reconstruction methods have not fully explored data consistency, resulting in poor performance.

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Objective: To characterize sleep duration and investigate its association with quality of life among Parkinson's Disease (PD) patients.

Methods: In this multicenter cross-sectional study, 970 PD patients were divided into five groups based on self-reported sleep duration: <5, ≥5 to <6, ≥6 to <7, ≥7 to ≤8, and >8 h. The quality of life was evaluated using the 39-Item Parkinson's Disease Questionnaire (PDQ-39).

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Background: Postoperative pain control is pivotal for surgical care; it facilitates patient recovery. Although patient-controlled analgesia (PCA) has been available for decades, inadequate pain control remains. Nurses' knowledge of and attitude toward PCA may influence the efficacy on clinic application.

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Background: While the challenges of COVID-19 are still unfolding, the enhancement of protective behavior remains a top priority in global health care. However, current behavior-promoting strategies may be inefficient without first identifying the individuals with lower engagement in protective behavior and the associating factors.

Objective: This study aimed to identify individuals with and potential contributing factors to low engagement in protective behavior during the COVID-19 pandemic.

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Article Synopsis
  • Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) are essential technologies for medical imaging, but current score-based models struggle with accurate 3D reconstructions due to their focus on 2D data.
  • The proposed TOSM (two-and-a-half order score-based model) improves upon these models by training on 2D data while using three-dimensional complementary scores during reconstruction to achieve better volumetric results.
  • Experimental results show that TOSM has set new benchmarks in CT and MRI reconstruction, providing significant improvements in image quality over existing methods.
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Purpose: This study aimed (1) to describe how trends in pediatric palliative care (PPC) utilization changed from 2002 to 2017, and (2) to examine factors predicting PPC utilization among decedent children in Taiwan.

Design: This retrospective, correlational study retrieved 2002-2017 data from three national claims databases in Taiwan.

Methods: Children aged 1 through 18 years who died between January 2002 and December 2017 were included.

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Article Synopsis
  • The score-based generative model (SGM) shows great promise in solving tough inverse problems in medical imaging, but it struggles with noisy or incomplete data typical in low-dose CT and under-sampled MRI scans.
  • To tackle this challenge, the authors propose a wavelet-improved denoising technique that integrates a wavelet sub-network with the standard SGM framework, enhancing training stability and accuracy even with noisy samples.
  • Experiments demonstrate that this combined approach significantly improves image reconstruction quality across various medical imaging scenarios, achieving results similar to those with clean data despite training on noisy samples.
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Objectives: To (1) modify the Mandarin-language 34-item Supportive Care Needs Survey-Adult Form into the Adolescent Form and (2) examine the psychometric properties of the Adolescent Form.

Data Sources: A multiphase, iterative scale validation process was used in this methodological study. Participants who were 13 to 18 years old and receiving cancer treatment in inpatient or outpatient settings, or receiving follow-up care in outpatient settings, were recruited using a convenience sampling method.

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