Physicochemical Properties and Cytoprotective Effects on PC12 Cells of Polysaccharides from (L.) DC. Obtained via a Gradient Ethanol Precipitation Method.

Given that the preparation method of polysaccharides affects the functional properties, four types of acidic polysaccharides (BCP30-1a, BCP50-1a, BCP70-1a, and BCP90-1a) were prepared using the gradient ethanol precipitation method. Then, a series of chemical and instrumental analysis techniques were used to compare structural characteristics and morphology. Neuroprotective effects were explored using OGD/R-induced PC12 cells.

Chiral Drug Resolution Nanochannels Inspired by Mitochondrial Membranes.

Fungicides have been widely used in agricultural production; however, their extensive use has caused serious environmental pollution. Because of its high efficiency, low toxicity, and high selectivity, chiral fungicides can effectively reduce the amount of fungicides and increase the efficiency. Hence, how to efficiently separate the enantiomers of chiral drugs with different structures is of significant research value.

A comprehensive and systemic review of the Gentiana: Ethnobotany, traditional applications, phytochemistry, pharmacology, and toxicology in the Mongolian Plateau.

Ethnopharmacological Relevance: Gentiana is the largest genus within the Gentianaceae family, comprising around 400 species that are widely distributed in temperate alpine regions worldwide, including the Mongolian Plateau. Despite their broad distribution, no comprehensive review on the distribution, ethnobotany, traditional uses, phytochemistry, pharmacology, and toxicology of Gentiana species in the Mongolian plateau.

Aim: This paper aims to provide the first detailed summary of Gentiana species distributed in the Mongolian Plateau, including those in Mongolia.

Trps1 regulates mouse zygotic genome activation and preimplantation embryo development via the PDE4D/AKT/CREB signaling pathway.

Despite zygotic genome activation (ZGA) is crucial for early embryonic development, its regulatory mechanism is still unclear in mammals. In the present study, we demonstrate that TRPS1, a maternal factor, plays an essential role in mouse early embryogenesis by regulating the transition from 2-cell to 4-cell embryos during preimplantation development. The absence of Trps1 could leads to impaired ZGA through AKT/CREB signaling pathway.

Autologous Hematopoietic Stem Cell Transplantation for Non-AL Amyloidosis Monoclonal Gammopathy of Renal Significance.

Background: The treatment strategy for non-AL amyloidosis monoclonal gammopathy of renal significance (MGRS) remains unstandardized. Autologous hematopoietic stem cell transplantation (ASCT) has shown favorable results in a limited number of studies.

Methods: This single-center, retrospective case-control study included non-AL amyloidosis MGRS patients diagnosed between February 2012 and July 2024; these patients were divided into the ASCT group and non-ASCT group.

The relationship between vision status and its influencing factors among primary and secondary school students: The masking effect of physical activity level and the moderating effect of academic stress.

Background: The global youth myopia rate continues to rise, and the vision health of primary and secondary school students has become a global concern. This cross-sectional study aims to explore the vision status of primary and secondary school students in the Ningxia Hui Autonomous Region, China, and its internal relationship with influencing factors under regional characteristics.

Methods: A survey was conducted among 1,670 primary and secondary school students in the Ningxia Hui Autonomous Region of China using a snapshot method and random sampling techniques from September to October 2023.

Clinicopathologic predictors of renal response and survival in newly diagnosed multiple myeloma with renal injury: a retrospective study.

Renal impairment (RI) is a common complication of multiple myeloma (MM), which is associated with poor prognosis. Here, we revealed the association between regular examination data and RI incidence, RI response and survival in newly diagnosed multiple myeloma (NDMM) patients. A retrospective analysis was conducted on the initial clinical data of 647 NDMM patients, comprising 193 patients (29.

A novel aptamer-based probe for the identification and enrichment of trophoblast cells.

Trophoblast cells, which are shed into the maternal reproductive tract, are emerging as a valuable source for prenatal diagnostic cells. However, the current enrichment efficiency of these cells is inadequate for clinical purposes. The reliance on antibody-based cell recognition methods has been a significant barrier to developing more effective enrichment techniques.

Construction of Sub-Nano Channels of Amino Pillar[6]arene Inspired Biomimetic Porous Roots for Specific Remove of Imazamox.

The root ducts play an important role in the plant's transport of nutrients from the soil. Based on the selective transport characteristics of plant roots, amino pillar[6]arene bionic porous root sub-nano channel membrane were constructed to remove Imazamox. Imazamox (IM) is an effective imidazolinone herbicide frequently utilized in soybean fields to control a wide range of annual grasses and broad-leaved weeds.

Age-specific abnormal glucose metabolism in HIV-positive people on antiviral therapy in China: a multicenter case-control study.

Background: Update, the link between HIV infection and abnormal glucose metabolism (AGM) is still unclear. This study aims to investigate the impact of HIV infection on AGM, including insulin resistance (IR), impaired fasting glucose (IFG), and diabetes mellitus (DM).

Methods: A multicenter case-control study was conducted in Zhejiang province, China.

Association of Albumin-To-Creatinine Ratio With Diabetic Retinopathy Among US Adults (NHANES 2009-2016).

Objective: This study investigates the relationship between the albumin-to-creatinine ratio and diabetic retinopathy (DR) in US adults using NHANES data from 2009 to 2016. This study assesses the predictive efficacy of the urinary serum albumin-to-creatinine ratio (UACR/SACR Ratio) against traditional biomarkers such as the serum albumin-to-creatinine ratio (SACR) and urinary albumin-to-creatinine ratio (UACR) for evaluating DR risk. Additionally, the study explores the potential of these biomarkers, both individually and in combination with HbA1c, for early detection and risk stratification of DR.

Organic trace elements enhance growth performance, antioxidant capacity, and gut microbiota in finishing pigs.

Excessive inorganic trace elements are added to livestock and poultry feed to meet the needs of animals, accompanied by frequent occurrence of excretion and gastrointestinal stress. Replacing inorganic trace elements with organic trace elements provides a promising solution to alleviate these problems. Therefore, this study aimed to assess the impact of replacing all inorganic trace elements (ITMs) in feed on the growth performance, meat quality, serum parameters, trace element metabolism, and gut microbiota of finishing pigs.

Comprehensive metabolic profiling of three plants of Ardisia based on UPLC-QTOF-MS coupled with bioactivity assays.

Ethnopharmacological Relevance: Ardisia is a large genus of Primulaceae, 734 accepted species worldwide, and most species are used as ethnomedicines for the treatment of bruises, rheumatism, tuberculosis, and various inflammatory diseases. According to our previous ethnobotanical survey, Ardisia gigantifolia Stapf, Ardisia hanceana Mez (Da-luo-san), and Ardisia crenata Sims (Xiao-luo-san) are commonly used in folk medicine for the treatment of rheumatism. Among them, A.

Chiral Membrane Containing Subnanometer Channels for Enantioselective Transport Amino Acids.

The research of chiral separation technology is of great significance for understanding the origin of life and promoting the application of chiral molecules. Herein, anionic chiral pillar[6]arene and cationic pillar[6]arene were designed and synthesized, and a chiral pillar[6]arene membrane was constructed by layer-by-layer assembly through electrostatic interactions. The transport rates of l and d in this channel were 14.

Enantioselective Carbonylative Cyclization of Alkenes with C-H Bonds for Synthesis of γ-Lactams Bearing an α-Quaternary Carbon.

The development of effective synthetic methods to construct γ-lactams bearing a chiral α-quaternary carbon from relatively inert C(O)-H bonds with alkenes has been an elusive challenge. Herein, we used a naphthylamine-derived phosphine oxide ligating Ni and Al bimetallic catalyst to realize a carbonylative cyclization of formyl C-H bonds with alkenes, highly regio- and enantioselectively constructing γ-lactams bearing a chiral α-quaternary carbon in up to 99% yield and 98% ee. These γ-lactams proved to be versatile synthetic precursors for many biologically active molecules.

Elevated serum miR-142-5p correlates with ischemic lesions and both NSE and S100β in ischemic stroke patients.

Background: This study aims to evaluate the correlation between miRNAs and known nerve injury markers neuron-specific enolase (NSE) and S100β in ischemic stroke (IS) patients, exploring its efficacy.

Methods: We retrospectively analyzed 86 IS patients and 32 healthy controls. Clinical and neurological examinations were performed in the admitted patients and the severity of neurological deficits was assessed by National Institutes of Health Stroke Scale (NIHSS).

New insights into the charge property at active sites boost PMS activation over LaFeMnO.

Perovskite-based materials have become a new direction for peroxymonosulfate (PMS) activation in pollutants degradation. However, the mechanism towards PMS activation remains insufficient. In this paper, a series of LaMMnO materials with B-site doping were developed by sol-gel self-propagating combustion method.

Development of an Angular Stiffness Sensor to Measure Dental Implant Stability In Vitro.

This investigation aims to develop an angular stiffness sensor intended for measuring dental implant stability in bone. The sensor hardware included a tiny eccentric motor and an accelerometer to measure a flex constant of an implant with its abutment. The sensor software included a mechanics-based model to convert the flex constant to angular stiffness at the implant/abutment junction to indicate the stability.

Sarcopenia and frailty among older Chinese adults: Findings from the CHARLS study.

Background: Sarcopenia and frailty are common among elderly individuals and present substantial health hazards. Exploring their relationship is essential for optimizing geriatric healthcare, particularly within the context of China.

Methods: A population-based cross-sectional design was employed using data from the China Health and Retirement Longitudinal Study (CHARLS).

Vision-Related Quality of Life After Fyodorov-Zuev Keratoprosthesis in China.

Purpose: The purpose of this study was to assess vision-related quality of life (VR-QoL) and its determinants in patients with implanted Fyodorov-Zuev (MICOF) KPro.

Methods: Eighty-eight patients with bilateral corneal blindness who underwent unilateral Fyodorov-Zuev (MICOF) KPro implantation were included in this cross-sectional study. VR-QoL was assessed using the National Eye Institute Visual Function Questionnaire-25 (NEI-VFQ-25).

Controlled Release of La Ions for Enhanced Wheat Seed Germination Based on Phosphate Pillar[5]arene Nanogating.

Rare earth elements (REEs), vital and limited resources, also play a significant role in agriculture. Previous findings indicated that the proper concentration of REEs could enhance the germination process, seed germination rate, and seedling growth and development. This paper introduces designing, synthesizing, and assembling a new type of tapered nanogates for separating and detecting lanthanide ions (La).