Adaptive damage analysis method for ultimate bearing capacity of steel truss structures with box section.

Traditional damage analysis of steel truss structures requires detailed finite element meshing, and there is a coupling between stress-strain and damage solving, resulting in complex damage analysis and massive computations. In this paper, the element bearing ratio (EBR) reflecting the bearing state of components was defined, and the concept of the element damage factor was introduced based on the principle of deformation energy conservation. A homogeneous generalized yield function (HGYF) for box-section components was constructed to establish adaptive damage factors and the criterion under multi-force combinations.

A Crystalline Polymer Cathode for Sodium-Organic Batteries.

Sodium-organic batteries (SOBs) are widely recognized as a rising star in large-scale energy storage technology because of their abundant resources, high energy density, and environmental friendliness. However, the poor cyclability and rate performance due to high solubility and poor conductivity with organic electrode materials limit their practical applications. Here, we constructed a new crystalline polymer poly(tetraaminobenzoquione) (PTABQ) featuring a layered structure with conjugated backbone and intermolecular hydrogen bonds.

Fully Methylated Siloxane-Based Electrolyte for Practical Lithium Metal Batteries.

Developing solvents with balanced physicochemical properties for high-voltage cathodes and lithium metal anodes is crucial for a sustainable and intelligent future. Herein, we report fully methylated tetramethyl-1,3-dimethoxydisiloxane (TMMS) as a single solvent for lithium metal batteries. We demonstrate that the fully methylated structure and Si-O bonds within TMMS can effectively elevate the dehydrogenation energy barrier, migrating the oxidation decomposition of the electrolyte.

DUSP4 inhibited tumor cell proliferation by downregulating glycolysis via p-ERK/p-PGK1 signaling in ovarian cancer.

Ovarian cancer (OC) remains a leading cause of gynecological cancer-related mortality, with poor prognosis and limited therapeutic options, underscoring the urgent need for a deeper understanding of OC biology. In this study, we identified a marked reduction in dual-specificity phosphatase 4 (DUSP4) expression in OC tissues compared to benign ovarian masses, with even further decreases observed in metastatic lesions. Moreover, DUSP4 expression varied among OC subtypes, with the lowest levels observed in serous ovarian cancer, and was associated with P53 and KI67 protein levels, altered TP53 mutation rates, advanced tumor stages, and poorer prognosis.

Metabolomics and machine learning approaches for diagnostic biomarkers screening in systemic light chain amyloidosis.

Delayed diagnosis of systemic light chain (AL) amyloidosis is common and associated with worse survival and early mortality. Current diagnosis still relies on invasive tissue biopsies, highlighting the need for sensitive, noninvasive biomarkers for early diagnosis. This study aims to identify promising biomarkers for the early diagnosis of AL amyloidosis.

Co-Fe-Mo Phosphides' Triphasic Heterostructure Loaded on Nitrogen-Doped Carbon Nanofibers by Electrospinning as Efficient Bifunctional Electrocatalysts for Overall Water Splitting.

The rational design of efficient and stable bifunctional electrocatalysts for the hydrogen evolution reactions (HER) and oxygen evolution reactions (OER) poses a significant challenge in realizing environmentally friendly hydrogen production through electrocatalytic water splitting. The construction of heterostructure catalysts, coexisting of multiple components, represents a favorable approach for increasing active sites, modulating electronic structure, accelerating charge transfer, decreasing reaction energy barriers, and synergistically enhancing electrocatalytic performance. In this study, a triphasic metal phosphides' heterostructure among CoP, FeP, and MoP loaded on nitrogen-doped carbon nanofibers (labeled as CoP-FeP-MoP@NC) was successfully synthesized through electrospinning and other subsequent steps as a bifunctional electrocatalyst material for water splitting.

[Screening and Preliminary Validation of Multiple Myeloma Specific Proteins].

Objective: To screen novel diagnostic marker or therapeutic target for multiple myeloma (MM).

Methods: and were identified by bioinformatics method based on GEO database as high expression genes in MM. Their RNA and protein expression levels in bone marrow mononuclear cells from myeloma cell lines U266, NCI-H929, MM.

Continuous Evolution of Eu/Eu Mixed Valency Driven by Pressure and Temperature.

Continuous mixed valency involving Eu and Eu in EuBiSe can be induced under applied pressure or at reduced temperatures. The monoclinic structure of EuBiSe, crystallizing in the 2/ space group (No. 11), features linear chains of Eu atoms aligned along the -axis.

Genetic Variation in a Crossing Population of Based on ddRAD Sequencing and Analysis of Association with Fruit Traits.

Tea oil is an important high-quality edible oil derived from woody plants. is the largest and most widely planted oil-producing plant in the genus in China, and its seeds are the most important source for obtaining tea oil. In current research, improving the yield and quality of tea oil is the main goal of oil tea genetic breeding.

Interplay of Crystal Structure and Magnetic Properties of the EuSrAlSb Solid Solution.

Zintl phases containing rare-earth metals have gained attention due to their magnetic, electronic, and thermoelectric properties. EuAlSb is a new structure type (monoclinic space group 2/) that can be described as a pseudorock-salt EuSb motif with the Eu-centered Sb octahedra at the origin of the unit cell, and on the C-face center, containing either Eu (8%) or an Al tetrahedron modeled as a dual tetrahedron (37.5%).

Revealing the dissolution mechanism of organic carbonyl electrodes in lithium-organic batteries.

Organic carbonyl electrode materials (OCEMs) have shown great promise for high-performance lithium batteries due to their high capacity, renewability, and environmental friendliness. Nevertheless, the severe dissolution of these materials in conventional electrolytes results in poor cycling stability, which hinders their practical application. Herein, a unified model considering the effects of both ion-solvation structures and electrolyte solvents is proposed to elucidate the dissolution mechanism of OCEMs in electrolytes.

Nanocrystals with Aggregate Anionic Structure Enable Ion Transport Decoupling of Chain Segment Movement in Poly(ethylene oxide) Electrolytes.

All-solid-state polymer electrolytes are promising for lithium batteries, but Li transport in these electrolytes relies on amorphous chain segment movement, leading to low Li mobility and poor mechanical strength. Here we propose a novel Li transport mechanism mediated by PEO:LiBF nanocrystals (NCPB) with the aggregate (AGG) anionic structure, which enables a change from amorphous to crystalline phase dominated ion transport in all-solid-state PEO/LiBF electrolyte. Experiments and simulations reveal that the interaction between Li and F in NCPB with AGG anionic structure simultaneously restricts anion transport and reorients anions within the free volume of NCPB, resulting in a three-coordination intermediate to facilitate Li transport.

Dual Active Site Covalent Organic Framework Anode Enables Stable Aqueous Proton Batteries.

Aqueous proton batteries (APBs) have attracted increasing interest owing to their potential for grid-scale energy storage with extraordinary sustainability and excellent rate abilities. However, there are limited anode materials and it remains a great challenge to effectively balance capacity and cycling performance. Here, we report a covalent organic framework containing C=O and C=N dual active sites (TABQ-COF) as a high-capacity and long-cycle anode for proton batteries.

Identification of Lauric Acid as a Potent Sodium Channel Na1.5 Blocker from Compound Chinese Medicine Wenxin Keli.

Purpose: The major cardiac voltage-gated sodium channel Na1.5 (I) is essential for cardiac action potential initiation and subsequent propagation. Compound Chinese medicine Wenxin Keli (WXKL) has been shown to suppress arrhythmias and heart failure.

Temperature-Dependent Structural Evolution of Ruddlesden-Popper Bilayer Nickelate LaNiO.

A recent article ( 2024, 146, 7506-7514) details a pressure-temperature (-) phase diagram for the Ruddlesden-Popper bilayer nickelate LaNiO (LNO-2222) using synchrotron X-ray diffraction. This study identifies a phase transition from (#63) to (#69) within the temperature range of 104-120 K under initial pressure and attributes the 4/ (#139) space group to the structure responsible for the superconductivity of LNO-2222. Herein, we examine the temperature-dependent structural evolution of LNO-2222 single crystals at ambient pressure.

5-Hydroxymethylcytosine Profiles of cfDNA in Urine as Diagnostic, Differential Diagnosis and Prognostic Markers for Multiple Myeloma.

Background: An effective urine-based method for the diagnosis, differential diagnosis and prognosis of multiple myeloma (MM) has not yet been developed. Urine cell-free DNA (cfDNA) carrying cancer-specific genetic and epigenetic aberrations may enable a noninvasive "liquid biopsy" for diagnosis and monitoring of cancer.

Methods: We first identified MM-specific hydroxymethylcytosine signatures by comparing 64 MM patients, 23 amyloidosis (AM) patients and 59 healthy cohort.

Glycyrrhizin Attenuates White Matter Injury by Inhibiting Neuroinflammation through the HMGB1/TLR4 Pathway.

White matter injury (WMI) is a common complication of preterm birth, potentially resulting in long-term behavioral and motor abnormalities. The objective of this study is to investigate the neuroprotective effects of glycyrrhizin (GLY) on WMI, and try to elucidate the potential mechanisms. In vivo chronic hypoxia-induced WMI mouse model and in vitro oxygen-glucose deprivation (OGD) induced WMI cell model were established, and the effects of GLY on WMI were explored through multiple assays, such as western blotting, immunofluorescence, immunohistochemistry, behavioral experiments, real-time quantitative polymerase chain reaction (RT-qPCR), transmission electron microscope (TEM), molecular docking, and bioinformatics analysis.

Polymorphism of Pb(PO)OH within the LK-99 mixture.

During the synthetic exploration targeting the polycrystalline compound LK-99, an unexpected phase, Pb(PO)OH, was identified as a byproduct. We elucidated the composition of this compound through single-crystal X-ray diffraction analysis. Subsequent synthesis of the target compounds was achieved via high-temperature solid-state pellet reactions.

UOTe: Kondo-Interacting Topological Antiferromagnet in a Van der Waals Lattice.

Since the initial discovery of 2D van der Waals (vdW) materials, significant effort has been made to incorporate the three properties of magnetism, band structure topology, and strong electron correlations-to leverage emergent quantum phenomena and expand their potential applications. However, the discovery of a single vdW material that intrinsically hosts all three ingredients has remained an outstanding challenge. Here, the discovery of a Kondo-interacting topological antiferromagnet is reported in the vdW 5f electron system UOTe.

SPC25 Activates the Warburg Effect to Inhibit Ferroptosis in Prostate Cancer Cells.

SPC25 is associated with unfavorable outcomes in various cancers, but its role in prostate cancer (PRAD) is unclear. More research is needed on glycolysis and ferroptosis targets in PRAD. Bioinformatics tools were used to analyze SPC25 expression disparities.

Ether-Modified Nonflammable Phosphate Enabling Anion-Rich Electrolyte for High-Voltage Lithium Metal Batteries.

Phosphate-based localized high-concentration electrolytes (LHCE) feature high flame retardant and satisfactory cathodic stability for lithium metal batteries. However, stable cycling of those electrolytes at ultra-high upper cut-off voltages for long-term stability remains challenging. Herein, an ether-modified phosphate, diethyl (2-methoxy ethoxy) methylphosphonate (DMEP), is designed for high-voltage applications.

Photothermal degradation of triphenylmethane dye wastewater by FeO@C-laccase.

The degradation of synthetic dye wastewater is important for green chemistry and cost-effectiveness. In this study, we developed FeO@C-laccase (laccase immobilized on FeO@C nanoparticles) for photothermal degradation of high concentration of triphenylmethane dye wastewater. The FeO@C-laccase possessed superior pH and thermal stabilities, as well as excellent tolerance to organic solvents, inhibitors, and metal ions.

Giant Uniaxial Magnetocrystalline Anisotropy in SmCrGe.

Magnetic anisotropy is a crucial characteristic for enhancing the spintronic device performance. The synthesis of SmCrGe single crystals through a high-temperature solution method has led to the determination of uniaxial magnetocrystalline anisotropy. Phase verification was achieved by using scanning transmission electron microscopy (STEM), powder, and single-crystal X-ray diffraction techniques.

A pyroxene-based quantum magnet with multiple magnetization plateaus.

Pyroxenes (AMXO) consisting of infinite one-dimensional edge-sharing MO chains and bridging XO tetrahedra are fertile ground for finding quantum materials. Thus, here, we have studied calcium cobalt germanate (CaCoGeO) and calcium cobalt silicate (CaCoSiO) crystals in depth. Heat capacity data show that the spins in both compounds are dominantly Ising-like, even after being manipulated by high magnetic fields.