Publications by authors named "Weiwei Shuai"
Article Synopsis
- Dosing vancomycin in critically ill neonates is difficult due to significant changes in how the drug behaves in their bodies, which can differ widely based on their health status and treatments.
- The study aimed to create a better model for understanding these changes through a physiologically based pharmacokinetic (PBPK) approach, using existing data and adapting it specifically for neonates.
- The research found that including detailed information about various health factors in the PBPK model led to more accurate predictions for vancomycin levels, improving dosing suggestions before actual serum tests are done.
Introduction: Few studies incorporating population pharmacokinetic/pharmacodynamic (Pop-PK/PD) modelling have been conducted to quantify the exposure target of vancomycin in neonates. A retrospective observational cohort study was undertaken in neonates to determine this target and dosing recommendations (chictr.org.
View Article and Find Full Text PDFRenal interstitial fibrosis (RIF) is a common pathological characteristic associated with end-stage renal disease. However, treatment strategies for RIF are still very limited. In this study, we reported that kaempferol, a classic flavonoid, exhibited strong and widely inhibitory effect on the expression of fibrosis related genes in transforming growth factor beta 1 (TGF-β1) treated NRK-52E cells.
View Article and Find Full Text PDFHypertrophic scar formation is a fibroproliferative disorder caused by abnormal wound healing. At present, there are limited treatment strategies for hypertrophic scars. In this study, we identified an endogenous peptide, LYENRL, through peptidomics screening that is downregulated in scar skin tissues.
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