Publications by authors named "Weissmann S"
Lynch Syndrome: Similarities and Differences of Recommendations in Published Guidelines.
J Gastroenterol Hepatol
January 2025
Background: In this review, we aimed to compare the recommendations for Lynch syndrome (LS).
Methods: We compared the LS's guidelines of different medical societies, including recommendations for cancer surveillance, aspirin treatment, and universal screening.
Results: Most guidelines for LS patients recommend intervals of 1-2 years for performing colonoscopy, though there is disagreement regarding the age to begin CRC screening (dependent on status as a MLH1/MSH2 or MSH6/PMS2 carrier).
Background: The lifestyle of the Arab population in Israel has changed in the last few decades, and modernization and urbanization have impacted the prevalence of chronic diseases.
Objectives: To investigate the prevalence of chronic diseases in the Arab population compared to the Jewish population in Israel.
Methods: This retrospective study included Arab and Jewish people insured by Israel's largest health maintenance organization.
Extensive research has been published on atopic dermatitis (AD), a prevalent skin condition among pediatricians. To assess the pediatric representation in the most cited literature on AD, using bibliometric analysis. Web of Science citation indexing database was used to identify publications with "atopic" and "dermatitis" or "eczema" in their title.
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- Alopecia Areata (AA) is an autoimmune disease that influences white blood cell activity, but previous research hasn't linked blood ratios to the condition's severity.
- A study comparing various blood cell ratios in over 147,000 AA patients and 141,000 healthy controls found higher Neutrophils-to-Lymphocytes Ratio (NLR) and Eosinophils-to-Lymphocytes Ratio (ELR) in AA patients, especially in those with moderate-severe cases.
- The findings suggest that these blood ratios could be useful for predicting and managing AA, contrary to earlier studies, making them a cost-effective tool for disease assessment.
Background: Prior studies demonstrated conflicting results regarding hematologic ratios in acne patients. We sought to further characterize hematologic ratios in acne patients, according to demographics and acne severity.
Methods: National, retrospective cohort study of 122,822 patients using medical records from 2005 to 2024 of patients insured with the largest public healthcare organization in Israel, Clalit Health Maintenance Organization.
Article Synopsis
- The study focused on the rising trend of early onset colorectal cancer (EO-CRC) in patients diagnosed between 1999 and 2021, analyzing risk factors compared to late onset colorectal cancer (LO-CRC).
- Out of 61,679 colorectal cancer patients surveyed, 5,561 were classified as EO-CRC, revealing a significant increase in EO-CRC cases over the past decades and identifying key risk factors such as gender, family history, ethnicity, and smoking status.
- EO-CRC patients showed lower rates of common comorbidities and had a significantly lower all-cause mortality rate compared to their LO-CRC counterparts, highlighting the need for targeted screening in high-risk groups, including young people with family histories
Vitiligo is characterized by depigmented skin lesions involving melanocyte defects and immune dysregulation. Haematological markers like neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been explored in various skin disorders. Given vitiligo's proposed pathogenesis, we hypothesized differences in NLR and PLR in vitiligo patients compared to controls.
View Article and Find Full Text PDFIntroduction: Atopic dermatitis (AD) is a common chronic skin disease with an inflammatory pathophysiology that includes the activation of the innate and adaptive immune systems. We aimed to investigate the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), eosinophil-to-lymphocyte ratio (ELR), and eosinophil-to-neutrophil ratio (ENR) in AD patients, according to age and disease severity.
Methods: This is a retrospective, population-based cohort study conducted between the years 2005 and 2020, comparing hematological markers of AD patients and sex-age-ethnicity-matched controls.
Article Synopsis
- Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease, and a study compared its impact between Arab and Jewish patients in Israel, analyzing data from over 200,000 individuals.
- Arab patients with NAFLD were diagnosed at a younger age and presented with higher rates of obesity, diabetes, and severe complications, such as cirrhosis and portal hypertension-related issues, compared to Jewish patients.
- Despite the higher complication rates, Arab patients demonstrated lower all-cause mortality and slightly higher liver transplantation rates, indicating the need for tailored prevention and treatment strategies based on ethnicity.
Article Synopsis
- Chronic spontaneous urticaria (CSU) is a skin condition that can significantly impact a person's quality of life, and markers of inflammation like neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios could be helpful in evaluating it.
- A study analyzed data from over 13,500 patients diagnosed with urticaria to explore these inflammatory markers in different patient groups, including acute versus chronic cases and varying severities.
- The findings indicated that CSU patients had higher inflammatory marker levels compared to those with acute urticaria, and higher levels correlated with more severe cases, suggesting these markers could help predict the severity and chronicity of urticaria.
Background: Psoriasis is a common skin disorder linked to systemic inflammation and immune dysregulation. It is believed to involve activated T cells and neutrophils. Recent research has highlighted the potential role of hematological ratios, such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), eosinophil-to-lymphocyte ratio (ELR), eosinophil-to-neutrophil ratio (ENR), and eosinophil-to-monocyte ratio (EMR), as markers for inflammatory skin diseases, including psoriasis.
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- Hematological markers like eosinophil-to-lymphocyte (ELR), eosinophil-to-neutrophil (ENR), and eosinophil-to-monocyte (EMR) ratios could help assess skin diseases, but their specific connection to vitiligo was uncertain.
- This study analyzed these markers in nearly 10,000 vitiligo patients and found that children had higher ratios than adults, and those with severe vitiligo exhibited even higher levels compared to mild cases.
- Elevated ENR and EMR ratios were associated with a significantly increased risk of developing severe vitiligo up to 18 months before diagnosis, suggesting these markers could aid in the prognosis of the condition.
Article Synopsis
- Treatment of chronic hepatitis C (HCV) with direct-acting antivirals (DAAs) can improve liver fibrosis, with 57% of patients showing improvement after at least three years post-treatment.
- A study of 209 patients revealed that factors like age at treatment and advanced fibrosis stage were significantly linked to the regression of fibrosis.
- While 71% of patients were treatment-naïve, 28% experienced significant improvement, moving from advanced fibrosis stages (F3/F4) to lower stages (F2 or less).
Objective: Acute bronchiolitis is the most common cause of hospitalization in young children. Data on monocyte-to-lymphocyte-ratio (MLR) and neutrophil-to-lymphocyte-ratio (NLR) as biomarkers are limited. We aim to evaluate these ratios in children hospitalized with respiratory syncytial virus (RSV) bronchiolitis and their value as biomarkers for severe clinical outcomes.
View Article and Find Full Text PDFBackground: Colorectal cancer (CRC) is a feared complication of inflammatory bowel disease (IBD). We aimed to investigate the prevalence and risk factors of CRC among a large cohort of IBD patients.
Methods: Data on IBD patients free of CRC at baseline was extracted using the MDClone platform of the Clalit health maintenance organization in Israel.
(1) Background: Non-alcoholic fatty liver disease (NAFLD) is a common liver disease. Aims: We aimed to investigate the frequency of comorbidities and malignancies among NAFLD patients compared to the general population. (2) Methods: A retrospective study included adult patients with a NAFLD diagnosis.
View Article and Find Full Text PDFBackground: One-third of psoriasis cases occur in the pediatric population. Pediatric psoriasis has a negative long-term impact on the quality of life of children and their families. However, data regarding the impact of pediatric psoriasis on parental sleep quality are scarce.
View Article and Find Full Text PDFSex-based medicine is an important emerging discipline within medicine. We investigated the clinical characteristics, complications, and outcomes of Nonalcoholic Fatty Liver Disease (NAFLD) in females compared to males. Demographics, comorbidities, malignancy, complications, outcomes, and all-cause mortality of NAFLD patients older than 18 years were analyzed.
View Article and Find Full Text PDFImmune checkpoint inhibitors are a class of cancer treatment drugs that stimulate the immune system's ability to fight tumor cells. These drugs are monoclonal antibodies targeting im-mune-inhibiting proteins on cancer cells, such as CTLA-4 and PD-1/PD-L1. Immune checkpoint inhibitors cause many immune-related adverse events.
View Article and Find Full Text PDFNon-small cell lung cancer (NSCLC) accounts for most lung cancers and is a leading cause of cancer-related deaths in the USA. Alterations in c-MET, a tyrosine kinase receptor, have been involved in many cases of NSCLC progression and metastasis. Crizotinib and other tyrosine kinase inhibitors (TKIs) have been used in NSCLC treatment with limited success.
View Article and Find Full Text PDFMalate transport shuttles atmospheric carbon into the Calvin-Benson cycle during NADP-ME C4 photosynthesis. Previous characterizations of several plant dicarboxylate transporters (DCT) showed that they efficiently exchange malate across membranes. Here, we identify and characterize a previously unknown member of the DCT family, DCT4, in Sorghum bicolor.
View Article and Find Full Text PDFUnderdeveloped immunity during the neonatal age makes this period one of the most dangerous during the human lifespan, with infection-related mortality being one of the highest of all age groups. It is also discussed that vaccination during this time window may result in tolerance rather than in productive immunity, thus raising concerns about the overall vaccine-mediated protective efficacy. Cyclic di-nucleotides (CDN) are bacterial second messengers that are rapidly sensed by the immune system as a danger signal, allowing the utilization of these molecules as potent activators of the immune response.
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