Biological mechanism and functional verification of key genes related to major depressive disorder and type 2 diabetes mellitus.

Major depressive disorder (MDD) and type 2 diabetes (TD) have been shown to be linked, but a comprehensive understanding of the underlying molecular mechanisms remains elusive. The purpose of this study was to explore the biological relationship between MDD and TD and verify the functional roles of key genes. We used the Gene Expression Omnibus database to investigate the targets associated with MDD and TD.

Safety evaluation of revefenacin at the approved dose in patients with chronic obstructive pulmonary disease: A meta-analysis.

Background: Revefenacin is the first once-daily long-acting muscarinic antagonist (LAMA) for nebulization use in maintenance therapy for patients with chronic obstructive pulmonary disease (COPD).

Objective: To investigate the safety and tolerability profile of revefenacin at the approved dose (175 μg), compared with placebo and a lower dose (88 μg), for the treatment of COPD.

Methods: Available randomized controlled trials (RCTs), both published and unpublished, were identified via databases.