Near-infrared light-heatable platinum nanozyme for synergistic bacterial inhibition.

The development of non-antibiotic strategies for bacterial disinfection is of great clinical importance. Among recently developed different antimicrobial strategies, nanomaterial-mediated approaches, especially the photothermal way and reactive oxygen species (ROS)-generating method, show many significant advantages. Although promising, the clinical application of nanomaterials is still limited, owing to the potential biosafety issues.

Nanoparticles-mediated ion channels manipulation: From their membrane interactions to bioapplications.

Ion channels are transmembrane proteins ubiquitously expressed in all cells that control various ions (e.g. Na, K, Ca and Cl etc) crossing cellular plasma membrane, which play critical roles in physiological processes including regulating signal transduction, cell proliferation as well as excitatory cell excitation and conduction.

A metal-organic framework nanocomposite with oxidation and near-infrared light cascade response for bacterial photothermal inactivation.

Photothermal treatment is an effective and precise bacterial disinfection method that can reduce the occurrence of bacterial drug resistance. However, most conventional photothermal treatment strategies have the problem that the photothermal response range does not match the infection area. Herein, a metal-organic framework (MOF) nanocomposite responding to the oxidation state of the bacterial infection microenvironment was constructed for near-infrared (NIR) photothermal bacterial inactivation.

A Retrospective Study of Puncture and Drainage for Primary Brainstem Hemorrhage With the Assistance of a Surgical Robot.

Background: Whether primary brainstem hemorrhage (PBH) should be treated with a conservative treatment or with surgical intervention (such as craniotomy, puncture, and drainage) is still controversial. The aim of this study was to assess the feasibility and safety of puncture and drainage for PBH with the assistance of a surgical robot.

Patients And Methods: A total of 53 patients diagnosed with PBH were included in this study.

Screening of multifunctional fruit carbon dots for fluorescent labeling and sensing in living immune cells and zebrafishes.

Nine kinds of carbon dots (CDs) were synthesized by using fruits with different varieties as carbon sources; meanwhile, the fluorescence characteristics, quantum yield, and response ability to different metal ions and free radicals were systematically studied. These CDs showed similar excitation and emission spectral ranges (λ ≈ 345 nm, λ ≈ 435 nm), but very different fluorescence quantum yield (QY), in which orange and cantaloupe CDs have the highest QY around 0.25 and green plum CDs showed the lowest quantum yield around 0.

Protein-Mediated Fluorescence Resonance Energy Transfer (P-FRET) Probe: Fabrication and Hydroxyl Radical Detection.

Fluorescent probes based on fluorescence resonance energy transfer (FRET) are highly promising for diverse bioapplications. The key to constructing FRET probes is to confine the donor and acceptor within a sufficiently close distance. However, the commonly used covalent linkage often requires elaborate design and complex organic synthesis, and sometimes causes changes in the fluorescence properties of the donor and acceptor.

A biodegradable and near-infrared light-activatable photothermal nanoconvertor for bacterial inactivation.

The development of biodegradable nanomaterials for near-infrared photothermal antibacterial is of great significance to improve the biosafety of nano-antibacterial strategies in clinical application. In this study, a new nano-antibacterial strategy was developed, in which a biodegradable charge-transfer nanocomplex acted as a high-efficiency near-infrared light-activatable photothermal nanoconvertor. The charge-transfer nanocomplex was synthesized through oxidation-induced self-assembly of 3,3',5,5'-tetramethylbenzidine molecules.

Will the Bacteria Survive in the CeO Nanozyme-HO System?

As one of the nanostructures with enzyme-like activity, nanozymes have recently attracted extensive attention for their biomedical applications, especially for bacterial disinfection treatment. Nanozymes with high peroxidase activity are considered to be excellent candidates for building bacterial disinfection systems (nanozyme-HO), in which the nanozyme will promote the generation of ROS to kill bacteria based on the decomposition of HO. According to this criterion, a cerium oxide nanoparticle (Nanoceria, CeO, a classical nanozyme with high peroxidase activity)-based nanozyme-HO system would be very efficient for bacterial disinfection.

Association between sleep duration and rupture of intracranial aneurysms: A single-center retrospective study.

Objective: To assess the relationship between sleep duration and risk of rupture of intracranial aneurysms (IAs).

Methods: According to our inclusion and exclusion criteria, 683 patients admitted to Beijing Tiantan Hospital were included in this study. There were 201 patients in the ruptured group and 482 patients in the unruptured group.

Is smoking a risk factor for bleeding in adult men with cerebral arteriovenous malformations? A single-center regression study from China.

Objective: To assess whether smoking increases the risk of bleeding in patients with cerebral arteriovenous malformations (CAVM).

Material And Methods: According to our research plan, 385 CAVM patients admitted to Beijing Tiantan Hospital from December 2015 to January 2018 were included in this study, including 210 bleeding patients and 175 non-bleeding patients. We divided patients into three subgroups of current smokers, ex-smokers (those who quit smoking for one year or more) and non-smokers.