Identification of KU-55933 as an anti-atherosclerosis compound by using a hemodynamic-based high-throughput drug screening platform.

Several compounds have been used for atherosclerosis treatment, including clinical trials; however, no anti-atherosclerotic drugs based on hemodynamic force-mediated atherogenesis have been discovered. Our previous studies demonstrated that "small mothers against decapentaplegic homolog 1/5" (Smad1/5) is a convergent signaling molecule for chemical [e.g.

Reciprocal-Activation Strategy for Allylic Sulfination with Unactivated Allylic Alcohols.

A reciprocal-activation strategy for allylic sulfination with unactivated allylic alcohols was developed. In this reaction, the hydrogen bond interaction between allylic alcohols and sulfinic acids allowed for reciprocal activation, which enabled a dehydrative cross-coupling process to occur under mild reaction conditions. This reaction worked in an environmentally friendly manner, yielding water as the only byproduct.

Dehydrative Cross-Coupling of Allylic Alcohols with Alkynes.

A highly efficient Pd/Ca catalytic system for the directly dehydrative cross-coupling of allylic alcohols with terminal alkynes was developed. This calcium salt cocatalyst facilitates the oxidative addition of the palladium catalyst (1 mol %) to the C-OH bond. Then, the in situ-generated hydroxide ion deprotonates the terminal alkynes to promote the formation of the allylalkynylpalladium intermediate, liberating water as the only byproduct.

A Ba/Pd Catalytic System Enables Dehydrative Cross-Coupling and Excellent -Selective Wittig Reactions.

A Ba/Pd cooperative catalysis system was developed to enable the dehydrative cross-coupling of allylic alcohols with P-ylides to occur directly and promote a subsequent Wittig reaction in one pot. A variety of multisubstituted 1,4-dienes were isolated in good to excellent yields with broad P-ylides (stabilized by both ester and ketone carbonyl groups) and aldehyde (aliphatic and aromatic) substrates with excellent selectivity.

Allylic Phosphorus Ylides Directly Generated from Alcohols with Water as the Only Byproduct.

A novel strategy for the preparation of allylic phosphorus ylides directly from Morita-Baylis-Hillman (MBH) alcohols in an environmentally benign manner was developed. With the assistance of a calcium catalyst, the S2' process between phosphines and allylic alcohols occurred smoothly, delivering allylic phosphorus salts and calcium-stabilized hydroxide ions. Then, in situ deprotonation gave the allylic phosphorus ylides with water as the only byproduct.

Barium-catalyzed C-OH/P-H dehydrative cross-coupling for C-P bond construction.

A barium-catalyzed C-OH/P-H dehydrative cross-coupling protocol for the construction of C-P bonds was developed. This reaction was performed in an environmentally benign manner with water as the only by-product. A variety of allylic phosphorus compounds can be isolated in good to excellent yields.

Direct Substitution of Secondary and Tertiary Alcohols To Generate Sulfones under Catalyst- and Additive-Free Conditions.

An environmentally benign protocol that affords propargylic sulfones containing highly congested carbon centers from easily accessible alcohols and sulfinic acids with water as the only byproduct is reported. The reaction proceeded via an in situ dehydrative cross-coupling process by taking advantage of the synergetic actions of multiple hydrogen bonds rather than relying on an external catalyst and/or additives to achieve high product distribution.

Bronsted Acid/Organic Photoredox Cooperative Catalysis: Easy Access to Tri- and Tetrasubstituted Alkenylphosphorus Compounds from Alcohols and P-H Species.

A Bronsted acid/organic photoredox cooperative catalytic system toward P-C bond formation from alcohols and P-H species is developed. With the assistance of visible light and TBHP, the reactions proceeded smoothly in an environmentally benign manner to give various alkenylphosphorus compounds in high efficiency.

Water-promoted C-S bond formation reactions.

Allylic sulfones, owning to their widespread distributions in biologically active molecules, received increasing attention in the past few years. However, the synthetic method under mild conditions is still a challenging task. In this paper, we report a sulfinic acids ligation with allylic alcohols via metal-free dehydrative cross-coupling.