K^{-}p Correlation Function from High-Energy Nuclear Collisions and Chiral SU(3) Dynamics.

The two-particle momentum correlation function of a K^{-}p pair from high-energy nuclear collisions is evaluated in the K[over ¯]N-πΣ-πΛ coupled-channel framework. The effects of all coupled channels together with the Coulomb potential and the threshold energy difference between K^{-}p and K[over ¯]^{0}n are treated completely for the first time. Realistic potentials based on the chiral SU(3) dynamics are used which fit the available scattering data.

A novel live-attenuated vaccine candidate for mayaro Fever.

Mayaro virus (MAYV) is an emerging, mosquito-borne alphavirus that causes a dengue-like illness in many regions of South America, and which has the potential to urbanize. Because no specific treatment or vaccine is available for MAYV infection, we capitalized on an IRES-based approach to develop a live-attenuated MAYV vaccine candidate. Testing in infant, immunocompetent as well as interferon receptor-deficient mice demonstrated a high degree of attenuation, strong induction of neutralizing antibodies, and efficacy against lethal challenge.

Safety and immunogenicity of recombinant Rift Valley fever MP-12 vaccine candidates in sheep.

The safety and immunogenicity of two authentic recombinant (ar) Rift Valley fever (RVF) viruses, one with a deletion in the NSs region of the S RNA segment (arMP-12ΔNSs16/198) and the other with a large deletion of the NSm gene in the pre Gn region of the M RNA segment (arMP-12ΔNSm21/384) of the RVF MP-12 vaccine virus were tested in crossbred ewes at 30-50 days of gestation. First, we evaluated the neutralizing antibody response, measured by plaque reduction neutralization (PRNT(80)), and clinical response of the two viruses in groups of four ewes each. The virus dose was 1×10(5)plaque forming units (PFU).

Developing brokered community transportation for seniors and people with disabilities.

Communities are exploring ways to increase transportation coordination to improve access for seniors. One such effort is a brokered transportation system in which one agency serves as the central point of contact for ride information or actually arranging transportation for clients of multiple programs by use of a combination of transportation services. A team of social work faculty and students from the University of New Hampshire (UNH) Social Work Outreach Center, a center that provides service learning opportunities to students, collaborated with a local coalition to investigate the specific transportation needs of the region's senior citizens.

Acid-base disturbances in gastrointestinal disease.

Disruption of normal gastrointestinal function as a result of infection, hereditary or acquired diseases, or complications of surgical procedures uncovers its important role in acid-base homeostasis. Metabolic acidosis or alkalosis may occur, depending on the nature and volume of the unregulated losses that occur. Investigation into the specific pathophysiology of gastrointestinal disorders has provided important new insights into the normal physiology of ion transport along the gut and has also provided new avenues for treatment.

Acute electrolyte and acid-base disorders in patients with ileostomies: a case series.

Background: Patients with ileostomies are well known to be susceptible to extracellular fluid volume depletion as a result of fluid and solute losses that are greater than intake. However, electrolyte and acid-base disorders accompanying these episodes of volume depletion are not well delineated.

Study Design: Case series.

Electroanatomic reconstruction of the left atrium, pulmonary veins, and esophagus compared with the "true anatomy" on multislice computed tomography in patients undergoing catheter ablation of atrial fibrillation.

Background: Current concepts of catheter ablation for atrial fibrillation (AF) commonly use three-dimensional (3D) reconstructions of the left atrium (LA) for orientation, catheter navigation, and ablation line placement.

Objectives: The purpose of this study was to compare the 3D electroanatomic reconstruction (Carto) of the LA, pulmonary veins (PVs), and esophagus with the true anatomy displayed on multislice computed tomography (CT).

Methods: In this prospective study, 100 patients undergoing AF catheter ablation underwent contrast-enhanced spiral CT scan with barium swallow and subsequent multiplanar and 3D reconstructions.

Coronary artery bypass graft mycotic aneurysms in a dialysis patient.

Infection is a common problem in dialysis patients and ranks second behind cardiovascular disease as a major cause of death. The major causes of infections, mainly bloodstream infections, often are related to dialysis access. Metastatic infectious complications have been reported frequently in the course of such bacteremias.

Propylene glycol-induced lactic acidosis in a patient with normal renal function: a proposed mechanism and monitoring recommendations.

Objective: To report a case of severe propylene glycol-induced lactic acidosis not attributable to renal dysfunction that was secondary to administration of high-dose intravenous lorazepam.

Case Summary: A 24-year-old female with community-acquired pneumonia presented with severe acute respiratory distress syndrome. To maintain adequate sedation and ventilation and reduce airway pressure, several relaxation strategies were used including high-dose intravenous lorazepam, fentanyl, and cisatracurium.

Kaonic hydrogen and K(-)p scattering.

Chiral SU(3) effective field theory in combination with a relativistic coupled-channels approach is used to perform a novel analysis of the strong-interaction shift and width in kaonic hydrogen in view of the new accurate DEAR measurements. Questions of consistency with previous K(-)p data are examined. Coulomb and isospin breaking effects turn out to be important and are both taken into account in this work.

Immunocytochemical identification of VPAC1, VPAC2, and PAC1 receptors in normal and neoplastic human tissues with subtype-specific antibodies.

Human tumors frequently overexpress receptors for vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP). However, none of the VIP/PACAP receptor proteins has been visualized individually in human tumors. Here, we developed and characterized a panel of antipeptide antibodies to the carboxyl-terminal regions of the VIP/PACAP receptor subtypes vasoactive intestinal peptide receptor (VPAC)1, VPAC2, and pituitary adenylate cyclase-activating peptide receptor (PAC)1.

Light-emitting field-effect transistor based on a tetracene thin film.

We report the first organic light-emitting field-effect transistor. The device structure comprises interdigitated gold source and drain electrodes on a Si/SiO(2) substrate. A polycrystalline tetracene thin film is vacuum sublimated on the substrate forming the active layer of the device.

Frequent expression of immunoreactive somatostatin receptors in cervical and endometrial cancer.

Objective: A variety of human cancers has been shown to express somatostatin receptors which can be utilized for in vivo tumor targeting. Although the somatostatin receptor status of mammary and ovarian cancer has been studied in detail, somatostatin receptors have not been examined in other gynecological malignancies such as cervical or endometrial carcinoma.

Methods: We have previously developed a panel of somatostatin receptor subtype-specific antibodies that effectively stain formalin-fixed, paraffin-embedded human tumor tissue.

Chiral dynamics of deeply bound pionic atoms.

We present and discuss a systematic calculation, based on two-loop chiral perturbation theory, of the pion-nuclear s-wave optical potential. A proper treatment of the explicit energy dependence of the off-shell pion self-energy together with (electromagnetic) gauge invariance of the Klein-Gordon equation turns out to be crucial. Accurate data for the binding energies and widths of the 1s and 2p levels in pionic 205Pb and 207Pb are well reproduced without need for a notorious "missing repulsion" in the pion-nuclear s-wave optical potential.

[Identification and characterisation of immune cells in the ejaculate of infertile and fertile men].

Using the immunoperoxidase technique with monoclonal antibodies the ejaculates of 20 infertile and 15 fertile men were examined for lymphocyte subsets and activation markers to know more about the cellular mucosal immunity in the male genital tract. The results have shown that there are small differences of T-helper (CD4), T-suppressor (CD8), B- (CD19) and Natural Killer cells (CD57) between both groups. The number of monocytes (CD14), activated T- and B-cells and macrophages (CD25), the LCA-positive cells (CD45) and the HLA-DR-positive cells were remarkably increased in fertile patients.

Local treatment of vaginal infections of varying etiology with dequalinium chloride or povidone iodine. A randomised, double-blind, active-controlled, multicentric clinical study.

This randomised, double-blind, multicentric clinical study compared the efficacy and tolerability of the two vaginal antiseptics, 10 mg dequalinium chloride (CAS 522-51-0, Fluomycin N) and 200 mg povidone iodine (CAS 25655-41-8), in a parallel-group design. A total of 180 patients with vaginal infections of varying etiology participated in this study (bacterial vaginosis, fluor vaginalis, vulvo-vaginal candidiasis, trichomoniasis). Patients were randomly allocated to one of the two treatment groups and were treated once per day for 6 days.

Frequency response of fiber-optic multilayer hydrophones: experimental investigation and finite element simulation.

The frequency response of a fiber-optic hydrophone that uses a dielectric multilayer system as the sensing element for ultrasound detection is investigated. A primary interferometric calibration technique is applied to determine by experiment the frequency-dependent pressure-voltage transfer function up to 45 MHz. The interaction between an incident pressure wave and the fiber end is analyzed by finite element methods.