The construction of an AIE-based controllable singlet oxygen generation system directed by a supramolecular strategy.

An aggregation-induced emission (AIE) based smart singlet oxygen (O) generation system has been successfully fabricated based on supramolecular host-guest assembly. The controllable O generation can be achieved by conveniently changing the molar ratio between the macrocyclic host (WP5) and the guest molecule (TPEPY). Moreover, reversible control of O generation and fluorescence emission of supramolecular nanoassemblies can be achieved via adding Fe and EDTA, which allows qualitatively monitoring the singlet oxygen generation efficiency by the naked eye.

Full-Color Tunable Fluorescent and Chemiluminescent Supramolecular Nanoparticles for Anti-counterfeiting Inks.

A drive for anti-counterfeiting technology has attracted considerable interests in developing nanomaterials with a wide range of colors and tunable optical properties in solid state. Herein, with a series of conjugated polymers and based on the host-guest driven self-assembly strategy, a color-tunable supramolecular nanoparticle-based system is reported, in which full-color as well as white fluorescence can be achieved. Moreover, this fluorescent platform exhibits reversible photoswitching between quenching and emission by noncovalently introducing a photoresponsive energy acceptor.

Multiresponsive Supramolecular Theranostic Nanoplatform Based on Pillar[5]arene and Diphenylboronic Acid Derivatives for Integrated Glucose Sensing and Insulin Delivery.

A closed-loop "smart" insulin delivery system with the capability to mimic pancreatic cells will be highly desirable for diabetes treatment. This study reports a multiple stimuli-responsive insulin delivery platform based on an explicit supramolecular strategy. Self-assembled from a well-designed amphiphilic host-guest complex formed by pillar[5]arene and a diphenylboronic acid derivative and loaded with insulin and glucose oxidase, the obtained insulin-GOx-loaded supramolecular vesicles can selectively recognize glucose, accompanied by the structure disruption and efficient release of the entrapped insulin triggered by the high glucose concentration as well as the in situ generated H O and acid microenvironment during the GOx-promoted specific oxidation of glucose into gluconic acid.