Publications by authors named "Weiru Jia"
Article Synopsis
- The study explores how modifying the surface of curcumin-loaded PLGA nanoparticles using fungal hydrophobin can impact their effectiveness as drug carriers in cancer treatment.
- Results showed that the hydrophobin-coated nanoparticles had better cytotoxicity and cellular uptake in cancer cell lines compared to non-coated ones, while maintaining a similar drug release pattern.
- Despite increased antitumor efficacy of the hydrophobin-coated nanoparticles in mice, there was no significant difference in blood retention time compared to the uncoated nanoparticles, indicating the need for further research on tissue distribution.
An HPLC-MS/MS method for simultaneous determination of decitabine and its valyl prodrug valdecitabine in rat plasma.
J Chromatogr B Analyt Technol Biomed Life Sci
February 2013
A simple and sensitive HPLC-MS/MS method was developed and validated for the simultaneous determination of decitabine and valdecitabine in rat plasma. The analytes were separated on a C(18) column (150mm×4.6mm, 3.
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