Bearing Capacity Performance and Optimal Design of a Novel Aluminum Alloy Arch Gusset Joint.

Current research on aluminum alloy gusset joints has neglected the influences of the angle between members and the curvature of the joint plate on joint performance. This study introduces the concept of the planar angle and establishes 16 joint models using ABAQUS finite element software with parameters such as the planar angle, arch angles, joint plate thickness, web thickness, and flange thickness. The load-bearing capacity of the novel aluminum alloy arch gusset joint is theoretically analyzed, and the concepts of strong and weak axes are proposed.

Ozone oil promotes wound healing via increasing miR-21-5p-mediated inhibition of RASA1.

Skin wound is a very common type of injury and the healing process greatly affects the life quality of individuals. Ozone has been shown beneficial to wound healing with unclear mechanisms. Here, we tested the effect of ozone oil (OZ) on wound healing and investigated the underlying mechanisms.

LINC0638 lncRNA is involved in the local recurrence of melanoma following surgical resection.

Melanoma is a rare malignancy in China and the treatment outcomes are generally satisfactory. However, postoperative recurrence can be life-threatening. The current study aimed to investigate the involvement of long intergenic non-protein coding RNA 1638 (LINC01638) long non-coding RNA (lncRNA) in the recurrence of melanoma.

Silencing of microRNA-27a facilitates autophagy and apoptosis of melanoma cells through the activation of the SYK-dependent mTOR signaling pathway.

Melanoma is considered as an aggressive neoplastic transformation and featured with high metastatic potential. Although some studies have provided targets for novel therapeutic interventions, clinical development of targeted drugs for melanoma still remains obscure. Therefore, this study aims to identify the role of microRNA-27a (miR-27a) in autophagy and apoptosis of melanoma cells in regulating spleen tyrosine kinase (SYK)-mediated the mammalian target of rapamycin (mTOR) signaling pathway.

Ozone oil promotes wound healing by increasing the migration of fibroblasts via PI3K/Akt/mTOR signaling pathway.

Skin injury affects millions of people via the uncontrolled inflammation and infection. Many cellular components including fibroblasts and signaling pathways such as transforming growth factor-β (TGF-β) were activated to facilitate the wound healing to repair injured tissues. C57BL/6 female mice were divided into control and ozone oil treated groups.

Protective effect of resveratrol against oxidative damage of UVA irradiated HaCaT cells.

Objective: To observe the photoprotective effect and possible mechanisms of resveratrol for ultraviolet A (UVA) irradiated HaCaT cells.

Methods: HaCaT cells under UVA irradiation with 5J/cm(2) were interfered with 0.01 mmol/L and 0.