Mechanistic insights into I seed implantation therapy for Cholangiocarcinoma: focus on ROS-Mediated apoptosis and the role of GPX2.

Objectives: Cholangiocarcinoma (CCA) is a rare tumor with a poor prognosis and poses significant therapeutic challenges. Herein, we investigated the mechanism of efficacy of I seed implantation therapy in CCA, focusing on the induction of reactive oxygen species (ROS)-mediated apoptosis and the involvement of glutathione peroxidase 2 (GPX2).

Materials And Methods: Human cholangiocarcinoma cell lines QBC939 and RBE were purchased for in vitro studies.

MiR-339-5p Inhibits Ferroptosis by Promoting Autophagic Degradation of FTH1 Through Targeting ATG7 in Liver Cancer Cells.

Background: Liver cancer has a high incidence and mortality rate worldwide, and there is an urgent need to identify new therapeutic strategies and predictive targets to improve the clinical outcomes of advanced liver cancer. Ferroptosis holds promise as a novel strategy for cancer therapy. Epigenetic dysregulation is a hallmark of cancer, and noncoding RNAs are tightly involved in cell fate determination.

Integrated Analysis of N1-Methyladenosine Methylation Regulators-Related lncRNAs in Hepatocellular Carcinoma.

N1-methyladenosine (m1A) and long non-coding RNAs (lncRNAs) play significant roles in tumor progression in hepatocellular carcinoma (HCC). However, their association with HCC is still unclear. In this study, lncRNAs related to m1A were extracted from the mRNA expression matrix in The Cancer Genome Atlas (TCGA) database.

Safety and Feasibility of Microwave Ablation for Hepatocellular Carcinomas in the Elderly: A Systematic Review.

Background: Microwave ablation (MWA) for hepatocellular carcinomas (HCCs) in the elderly has been the subject of new research in recent years. However, there are currently no strong lines of evidence for the prognosis following MWA treatment for HCC in the elderly. Therefore, we conducted a systematic review to assess the safety and feasibility of MWA for HCC in elderly patients.

RNA m6A reader YTHDF1 facilitates inflammation via enhancing NLRP3 translation.

N-methyladenosine (m6A) modification of mRNAs is involved in multiple essential biological processes, dynamically regulated by m6A "writers", "erasers", and "readers". Yet, the detailed functional roles of RNA m6A reader proteins, such as YTHDFs, are largely unknown. Herein we show that YTHDF1 promotes pro-inflammatory IL-1β production in macrophages during bacterial infections.

Establishment and Validation of an MTORC1 Signaling-Related Gene Signature to Predict Overall Survival in Patients with Hepatocellular Carcinoma.

Background: Accurate and effective biomarkers for the prognosis of patients with hepatocellular carcinoma (HCC) are poorly identified. A network-based gene signature may serve as a valuable biomarker to improve the accuracy of risk discrimination in patients.

Methods: The expression levels of cancer hallmarks were determined by Cox regression analysis.

Area-population control of fungus-growing termite, Odontotermes formosanus, using hexaflumuron durable baits.

Background: Fungus-growing termites (Termitidae: Macrotermitinae) are common forest and agriculture pests. To evaluate the efficacy of termite baiting in suppressing field population of fungus-growing termites, a durable termite bait with hexaflumuron was evenly installed in a one-hectare forest area dominated by a fungus-growing termite, Odontotermes formosanus (Shiraki). Monthly monitoring of termite foraging activity on baits and wood stakes was conducted for 4 years to quantify efficacy of baits.

The first record of the subfamily Dasycerinae in Taiwan, with description of a new species (Coleoptera: Staphylinidae).

Dasycerus poseidon Hu Liang, sp. nov. is described and illustrated based on fresh specimens from central and southern Taiwan, which filled in the disjunct distribution between the Japanese archipelago and south-eastern Asia.

Gut microbiota shifts in patients with gastric cancer in perioperative period.

Gastric cancer (GC) is one of the common malignant tumors in China, with a high morbidity and mortality. With the development and application of high-throughput sequencing technologies and metagenomics, a great quantity of studies have shown that gastrointestinal microbiota is closely related to digestive system diseases. Although some studies have reported the effect of long-term follow-up after subtotal gastrectomy on intestinal flora changes in patients with GC.

Identification of Subterranean Termite Genus, Reticulitermes (Blattodea: Rhinotermitidae) in Taiwan.

Species identification in the genus Reticulitermes is often difficult because of ambiguous morphological characters. Challenges in Reticulitermes spp. recognition have also been encountered in East Asia, including Taiwan.

Nematode-free agricultural system of a fungus-growing termite.

Fungus-growing termites forage dead plant materials from the field to cultivate symbiotic Termitomyces fungi in the nest. Termite foraging behavior and the entry of symbiotic arthropod inquilines may transfer nematodes into a nest and adversely affect fungus production. To test whether nematodes were transferred to fungus gardens by termites and inquilines, we examined the occurrence of nematodes in fungus gardens, five termite castes, and nine species of inquilines of a fungus-growing termite, Odontotermes formosanus.

() sp. n., a new termitophilous species from Taiwan (Coleoptera: Staphylinidae: Aleocharinae: Lomechusini).

The staphylinid tribe Lomechusini is known for the diverse associations with ants or termites. A new species of rove beetle belonging to Zyras (Diaulaconia) is found to be associated with the fungus-growing termite, Odontotermes formosanus (Shiraki, 1909), and is showing meticulous predatory behavior. In the present study, this species is described as Zyras (Diaulaconia) artemis Liang, Maruyama & Li, sp.

Carotid blowout syndrome after nasopharyngeal carcinoma radiotherapy: successful treatment by internal carotid artery occlusion after stent implantation failure.

Introduction: Carotid blowout syndrome (CBS) secondary to radiation therapy is life-threatening and requires emergency treatment. More recently, endovascular treatment has provided an effective way to control CBS-related bleeding.

Case Description: We present a case of CBS with a rupture of the internal carotid artery (ICA) pseudo-aneurysm after Gamma Knife radiation therapy for nasopharyngeal carcinoma (NPC).

Descriptions of the mature larvae for two species of Pseudopyrochroa from Taiwan (Coleoptera: Pyrochroidae: Pyrochroinae), with notes on their natural history.

Field collections and rearing have established the first species-level associations for larvae of Pyrochroidae from Taiwan. Larvae of Pseudopyrochroa carinifrons and Pseudopyrochroa fainanensis were collected from beneath bark and in coarse, decaying woody debris of dead logs and successfully reared to the respective adult stages. The mature larvae are described and salient features are illustrated.

Use of magnetic resonance elastography for assessing liver functional reserve: A clinical study.

Aim: To investigate the value of magnetic resonance elastography (MRE) with regard to assessing liver functional reserve.

Methods: Data from inpatients diagnosed with a liver tumor at an interventional radiology department from July 2013 to June 2014 were analyzed. A 3.