Dihydromyricetin protects against Doxorubicin-induced cardiotoxicity through activation of AMPK/mTOR pathway.

Background: Doxorubicin (DOX) is a highly effective broad-spectrum antitumor agent, but its clinical administration is limited by self-induced cardiotoxicity. Dihydromyricetin (DHM) is a flavonoid compound extracted from the Japanese raisin tree. Evidence that DHM has neovascular protective properties makes it a candidate for studying cardiotoxicity prevention strategy.

Antimicrobial lanostane triterpenoids from the fruiting bodies of .

A chemical investigation on the 90% EtOH extract of the fruiting bodies of led to the isolation of three new lanostane triterpenoids, designated as 25-methoxy-11-oxo-ganoderiol D (), 3-oxo-25-methoxy-24,26-dihydroxy-lanosta-7,9(11)-diene (), and 3-acetyloxy-lucidone H (). Structural elucidation of all the compounds were performed by spectral methods such as 1 D and 2 D (HH COSY, HMQC, and HMBC) NMR spectroscopy. All the triterpenoids were evaluated for their antimicrobial activities against six pathogenic microorganisms.

Antimicrobial mexicanolide limonoids from the seeds of .

Three new mexicanolide limonoids were obtained from the 90% ethanol extract of the seeds of Their structures were elucidated as senegalenines AC () by analysing their 1D/2D NMR and MS spectroscopic analysis. In addition, the isolated limonoids were tested for antimicrobial potentials against 5 pathogenic microorganisms. Consequently, compounds exhibited antimicrobial activity against the tested Gram negative bacteria at the minimum inhibitory concentration values less than 40 μg/ml.

Cytotoxic and antibacterial aspidofractinine alkaloids from Kopsia hainanensis.

The ethanol extract of the twigs and leaves of Kopsia hainanensis afforded six new aspidofractinine alkaloids, kopsiahainanins A-F (1-6), among which alkaloids 1 and 2 possessed a lactone bridge with novel regiochemistry. The structures of the isolated compounds were established based on 1D and 2D (HH COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated compounds were tested in vitro for cytotoxic activity against seven tumor cell lines and antibacterial activities against two Gram-positive bacteria and five Gram-negative bacteria.