Publications by authors named "Weiquan Zeng"
Article Synopsis
- Glioblastoma multiforme (GBM) is a highly lethal brain tumor with limited treatment options, and sophocarpine, an alkaloid, shows potential as an anti-tumor agent.
- In experiments, sophocarpine effectively inhibited the growth, migration, and proliferation of GBM cells while inducing apoptosis and cell cycle arrest.
- The study revealed that sophocarpine works through the PTEN/PI3K/Akt signaling pathway, making it a promising candidate for GBM therapy.
Article Synopsis
- Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with a poor prognosis, and deguelin, derived from an African plant, shows potential as a treatment option.
- Research indicates that deguelin reduces the survival of GBM cells by blocking their progression in the cell cycle and inducing cell death, while also preventing their movement (migration).
- Key findings suggest that deguelin decreases the levels of the chemokine CCL2, which influences tumor growth and the tumor microenvironment by affecting the NFκB signaling pathway, indicating a possible new approach for GBM therapy.
Glioblastoma (GBM) is a human malignant tumor with low survival and high recurrence rate. Angelicin, an active furanocoumarin compound, has been reported to possess potential antitumor activity towards various malignancies. However, the effect of angelicin on GBM cells and its mechanism are still unclear.
View Article and Find Full Text PDFBackground: Neferine exhibits therapeutic effects on anti-hypertension. However, the effect of neferine on hypertensive vascular remodeling remains unexplored. Therefore, the current study was to investigate the effect of neferine on hypertensive vascular remodeling and its underlying mechanisms.
View Article and Find Full Text PDFWe assessed the role of the protein-coding gene chaperonin-containing TCP1 subunit 6A (CCT6A) in osteosarcoma, as this is currently unknown. Using data from the R2 online genomic analysis and visualization application, we found that CCT6A messenger ribonucleic acid (RNA) expression is increased in osteosarcoma tissue and cells. Transfection of CCT6A small interfering RNA into cultured osteosarcoma cells revealed that CCT6A knockdown attenuates cell growth, cell viability, cell survival, and induced apoptosis and cell cycle progression at the G0/G1 phases.
View Article and Find Full Text PDFObjective: To observe the effect of acupotomy on the expression of Beclin-1, Bcl-2 and Caspase-3 in the cartilage tissue in rabbits with knee osteoarthritis (KOA), so as to explore its mechanism underling improvement of KOA.
Methods: Twenty-four healthy male New Zealand rabbits were randomly and equally divided into blank control, model and acupotomy groups, with 8 rabbits in each group. By using the modified Videman's methods, the KOA model was established by left hind limb immobilization with a plaster cast for 6 weeks.
Proteomic Analyses Reveals the Mechanism of Acupotomy Intervention on the Treatment of Knee Osteoarthritis in Rabbits.
Evid Based Complement Alternat Med
November 2022
Acupotomy intervention (AI) is an available treatment for knee osteoarthritis (KOA) in China, which is a common health problem over the world. However, the underlying mechanism of AI on the KOA treatment is still unknown. To further understand the mechanism of acupotomy in treating KOA, the morphological observation and TMT proteomic analyses were conducted in rabbits.
View Article and Find Full Text PDFArticle Synopsis
- The collapse of the Pb/Zn tailing dam in Huanjiang, Guangxi has caused severe acidification and heavy metal contamination in farmland along the Huanjiang River, leading to a decline in agricultural productivity.
- This study tested various soil amendments (lime, calcium magnesium phosphate, organic fertilizer, polypropylene amide) to address these issues through soil leaching tests, finding that some amendments significantly improved soil pH and reduced heavy metal mobility.
- Amended soils showed better growing conditions for plants, particularly through the use of organic fertilizer and polypropylene amide, indicating potential pathways for bioremediation efforts in the heavily contaminated area.