[Bacterial Community and Diversity of River Ecosystems on the Qinghai-Tibet Plateau Based on 16S rRNA Gene Sequencing].

In recent years, the ecosystems on the Qinghai-Tibet Plateau (QTP) have been facing a high risk of degradation due to the impacts of climate change and human activities. As one of the important components in river ecosystems, microbial communities can reflect the overall changes in the watershed and are regarded as indicators of the health of river ecosystems. In order to investigate the diversity and composition characteristics of bacterial communities in river ecosystems on the QTP, 65 samples were collected from the Yellow River, Yangtze River, Lancang River, Nujiang River, Yarlung Tsangpo River, and Qaidam Basin on the QTP in July 2021 and were analyzed using 16S rRNA high-throughput sequencing.

MiR-552 promotes the proliferation, migration and EMT of hepatocellular carcinoma cells by inhibiting AJAP1 expression.

Our goal was to explore the function of miR-552 and its potential target AJAP1 in hepatocellular carcinoma (HCC) oncogenesis and progression. In this study, bioinformatics analysis was performed to detect abnormally expressed miRNAs. The relationship between miR-552 and AJAP1 was validated using luciferase reporter assays.

Clinical value of microRNA-23a upregulation in non-small cell lung cancer.

Background: MiR-23a function as an oncogene in several human cancers, however, its clinical value has not been investigated in NSCLC.

Methods: Tissue samples were obtained from 127 NSCLC patients who underwent complete resection at Yantaishan Hospital from March 2008 to January 2014. The expression level of miR-23a was detected in NSCLC tissues and the matched adjacent lung tissues by qRT-PCR.

Down-regulation of miR-503 expression predicate advanced mythological features and poor prognosis in patients with NSCLC.

Objective: We aimed to explore what impact miR-503 has on the prognosis of patients with non-small cell lung cancer (NSCLC).

Methods: Cancer and matched non-malignant lung tissue specimens were collected from 109 patients who underwent surgery in Tanisha Hospital from Jun 2006 to July 2013. Overall survival (OS) curves were analyzed using the Lapland-Meier method, and the differences were examined using log-rank tests.