Publications by authors named "Weiqiao Shi"
Background: Although reports suggest Chinese herbal medicine treatment of ovarian cancer (OC) has a good effect, the role of isorhamnetin (ISO), a flavonol aglycone with immune, anti-inflammatory, cardiovascular and cerebrovascular protective effects, as well as an anticancer effect, in OC remains unclear. Network pharmacology was used to explore this and , and to identify relevant targets.
Methods: The common targets of ISO in the treatment of OC were screened by constructing drug targets and disease gene databases for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses.
Article Synopsis
- This study explored how genetic variations in enzymes that process azathioprine relate to adverse effects, specifically myelosuppression, in 1,419 Chinese patients with various diseases.
- The research identified that the (415C>T) genetic mutation significantly correlated with a higher likelihood of myelosuppression, with 83.33% of patients with the highest risk genotype experiencing this adverse effect.
- Findings suggest that genotyping for (415C>T) and (94C>A) should be done before prescribing azathioprine, especially to prevent potential myelosuppression in those with specific genetic mutations.