[Research progress on GSDME-mediated cell pyroptosis resulting in GSDME type hearing loss].

Pyroptosis is a novel mode for programmed cell death discovered and confirmed in recent years. The Gasdermins (GSDMs) family is a key effector molecule mediating pyroptosis. As an important cause of extensive inflammatory damage and side effects of conventional chemotherapy drugs, anomalous pyroptosis has also been associated with hearing loss, tumor, and disorders of the immune system.

The Influence of High-Concentrate Diet Supplemented with Tannin on Growth Performance, Rumen Fermentation, and Antioxidant Ability of Fattening Lambs.

This experiment aimed to study the effects of tannin supplementation on growth performance, rumen fermentation characteristics, apparent digestibility and serum biochemistry, and antioxidant and immune indexes in fattening lambs. A total of 36 male Hu sheep lambs (body weight = 15.83 ± 0.

Migration of fluoranthene, phenanthrene, and pyrene in soil environment during the growth of Brassica rapa subsp. chinensis.

The escalating concern surrounding fluoranthene (FLN), phenanthrene (Phe), and pyrene (Pyr), underscores the urgency to investigate their dynamics in the context of agricultural ecosystems. Brassica rapa subsp. chinensis (Bok choy), a globally consumed vegetable, holds particular significance in this scenario.

Study on Fast Liquefaction and Characterization of Produced Polyurethane Foam Materials from Moso Bamboo.

Although bamboo is widely distributed in Japan, its applications are very limited due to its poor combustion efficiency for fuel. In recent years, the expansion of abandoned bamboo forests has become a social issue. In this research, the possibility of a liquefaction process with fast and efficient liquefaction conditions using moso bamboo as raw material was examined.

Risk factors for esophageal anastomotic stricture after esophagectomy: a meta-analysis.

Background: The aim of this study was to assess the risk factors for anastomotic stricture in esophageal cancer patients undergoing esophagectomy. Esophageal anastomotic stricture is the most common long-term complication for esophagectomy. The risk factors for esophageal anastomotic stricture still remain controversial.

Characterization of Microplastics and Adsorbed/Dissolved Polycyclic Aromatic Hydrocarbons in the Biggest River System in Saitama and Tokyo, Japan.

This study presents a comprehensive characterization of microplastics (MPs) and adsorbed/dissolved polycyclic aromatic hydrocarbons (PAHs) in the Arakawa River, the largest river system in Saitama and Tokyo, Japan. The MPs were sampled at various points along the river, revealing an average number density of 2.21 ± 1.

Microplastic Contamination of Non-Mulched Agricultural Soils in Bangladesh: Detection, Characterization, Source Apportionment and Probabilistic Health Risk Assessment.

Microplastic contamination in agricultural soil is an emerging problem worldwide as it contaminates the food chain. Therefore, this research investigated the distribution of microplastics (MPs) in agricultural soils without mulch at various depths (0-5, 5-10, and 10-15 cm) across different zones: rural, local market, industrial, coastal, and research areas. The detection of MP types and morphology was conducted using FTIR and fluorescence microscopy, respectively.

Physicochemical Characterization and Oxidative Potential of Iron-Containing Particles Emitted from Xuanwei Coal Combustion.

Respiratory diseases have been proven to be directly related to air pollutants. Xuanwei, located in South China, has been known to have the highest mortality rate for lung cancer in China because of the air pollutants emitted through local coal combustion. However, the mechanism of lung cancer induced by air pollutants is not clear.

Examining the impact of nanoplastics and PFAS exposure on immune functions through inhibition of secretory immunoglobin A in human breast milk.

Emerging contaminants such as nanoplastics (NPs) and per- and polyfluoroalkyl substances (PFAS), have been detected in the environment and breast milk, thus exposing infants to potentially harmful chemicals during breastfeeding. Breast milk contains secretory immunoglobulin A (SIgA), an antibody that plays a vital role in disease protection and the development of the infant's immune system. This study employed molecular simulation and fractional factorial designs to assess the toxicity of NPs and PFAS on breast milk and their influence on infant immunity by inhibiting SIgA.

[Anti-fatigue effect of Lubian on kidney Yin deficiency and kidney Yang deficiency mice and mechanism based on PI3K-Akt pathway].

This study aimed to investigate the anti-fatigue effect and mechanism of Lubian(Cervi Penis et Testis) on kidney Yin deficiency and kidney Yang deficiency mice. After one week of adaptive feeding, 88 healthy male Kunming mice were randomly divided into a blank group, a kidney Yin deficiency model group, a kidney Yin deficiency-Panacis Quinquefolii Radix(PQR) group, kidney Yin deficiency-Lubian treatment groups, a kidney Yang deficiency model group, a kidney Yang deficiency-Ginseng Radix et Rhizoma(GR) group, and kidney Yang deficiency-Lubian treatment groups, with eight mice in each group. The kidney Yin deficiency model and kidney Yang deficiency model were prepared by daily regular oral administration of dexamethasone acetate and hydrocortisone, respectively, and meanwhile, corresponding drugs were provided.

Species difference in toxicokinetics and safety assessment of senecionine N-oxide in a UDP-glucuronosyltransferase 1A4 humanized mouse model.

Pyrrolizidine alkaloids (PAs) are naturally occurring hepatotoxins, and herbs containing PAs are of high concern. PAs are normally found in tertiary amines and N-oxide forms (PA N-oxides), yet the latter are less evaluated for their toxicokinetics. As a continuation of our investigation into the safety assessment of PA-containing herbal medicines, the toxicity and toxicokinetic characteristics of senecionine N-oxide (a representative toxic PA N-oxide) were investigated by using the UDP-glucuronosyltransferase 1A4 humanized mouse model (hUGT1A4 mouse model) and compared with those in wild-type mice simultaneously.

Freshwater species diversity loss embodied in interprovincial hydroelectricity transmission with ecological network analysis.

A major strategy for addressing the imbalance in source-network-load distribution is interprovincial electricity transmission; however, this process also causes various environmental effects. Previous studies have mainly examined thermal power transmission, and few insights have been gained into the challenges hydroelectricity transmission poses for biodiversity conservation. Here, we innovatively incorporated the freshwater species diversity footprint into a hydropower environmental impact assessment, calculating the interprovincial transfer of freshwater species diversity embodied in hydroelectricity transmission.

Screening and characterization of inhibitory vNAR targeting nanodisc-assembled influenza M2 proteins.

Influenza A virus poses a constant challenge to human health. The highly conserved influenza matrix-2 (M2) protein is an attractive target for the development of a universal antibody-based drug. However, screening using antigens with subphysiological conformation in a nonmembrane environment significantly reduces the generation of efficient antibodies.

Addition of an affected family member to a previously ascertained autosomal recessive nonsyndromic hearing loss pedigree and systematic phenotype-genotype analysis of splice-site variants in MYO15A.

Pathogenic variants in MYO15A are known to cause autosomal recessive nonsyndromic hearing loss (ARNSHL), DFNB3. We have previously reported on one ARNSHL family including two affected siblings and identified MYO15A c.5964+3G > A and c.

A newborn male with Myhre syndrome, hearing loss, and complete syndactyly of fingers 3-4.

Background: Myhre syndrome is a rare multisystem genetic disorder that is caused by de novo heterozygous gain-of-function variants in SMAD4. Patients with Myhre syndrome exhibit several phenotypes at different ages such as small size, autism, developmental delay, left-sided heart defects, and hearing loss and often have a characteristic facial appearance. The early clinical diagnosis of Myhre syndrome remains a major challenge, particularly in the first year of life.

Pollution levels and health risk assessment of potentially toxic metals of size-segregated particulate matter in rural residential areas of high lung cancer incidence in Fuyuan, China.

The highest incidence and mortality rate of lung cancer in rural area of Fuyuan has been a research hotspot, and the pathogenesis is still unclear. Therefore, atmospheric particulate matters (APMs) samples were collected between 18 February and 01 March 2017, exploring water-soluble potentially toxic metals (WSPTMs) and water-soluble inorganic ionic species (WSIIs) levels, size distribution, sources, acidity and alkalinity, and potential carcinogenic and non-carcinogenic risks, hoping to provide scientific basic data to solve this problem. In our study, the average ratio of nitrate ion (NO)/sulfate ion (SO) within PM, PM, PM, PM, and PM were 0.

Novel Approaches for Inhibiting the Indoor Allergen Der f 2 Excreted from House Dust Mites by Todomatsu Oil Produced from Woodland Residues.

House dust mite (HDM) is a globally ubiquitous domestic cause of allergic diseases. There is a pressing demand to discover efficient, harmless, and eco-friendly natural extracts to inhibit HDM allergens that are more likely to trigger allergies and challenging to be prevented entirely. This study, therefore, is aimed at assessing the inhibition of the allergenicity of major HDM allergen Der f 2 by todomatsu oil extracted from residues of .

Pollution characteristics and risk assessment of potentially toxic elements of fine street dust during COVID-19 lockdown in Bangladesh.

Due to the COVID-19 pandemic, Bangladesh government took the measure like partial lockdown (PL) and complete lockdown (CL) to curb the spread. These measures gave a chance for environmental restoration. In this study, street dust samples were collected during PL and CL from four main urban land use categories in Dhaka city, such as industrial area (IA), commercial area (CA), public facilities area (PFA), and residential area (RA).

Lung Cancer Stage Prediction Using Multi-Omics Data.

Lung cancer is one of the leading causes of cancer death. Patients with early-stage lung cancer can be treated by surgery, while patients in the middle and late stages need chemotherapy or radiotherapy. Therefore, accurate staging of lung cancer is crucial for doctors to formulate accurate treatment plans for patients.

Explore the attitudes of children and adolescent parents towards the vaccination of COVID-19 in China.

Background: With the increasing incidence of asymptomatic carriers or milder symptoms, children and adolescents are likely to become a silent source of infection. In view of the efficacy and safety of vaccines in the treatment of novel Coronavirus pneumonia, population-wide vaccination will be an inevitable trend to control the spread of COVID-19. However, there is no survey on the attitudes of Chinese parents of children and adolescents towards their children's COVID-19 vaccination.

Analysis of the trade-off between hydroelectricity generation and ecological protection from the perspective of eco-efficiency in Southwest China.

Driven by the global net-zero carbon emission goal, even though the impact of hydropower on river ecosystems cannot be ignored, hydropower scale and intensity will be expanded in Southwest China (SC). Therefore, the trade-off between hydroelectricity generation and ecological protection remains an issue requiring urgent attention at the moment. This paper proposes an eco-efficiency (EE) indicator system of hydropower adopting the water consumption of hydropower product (PWC), labor, and capital as inputs and the power generation, ecological flow deviation (EFD) as outputs and then explores the factors influencing the EE value of hydropower in SC.