Publications by authors named "Weiqian Hu"
Article Synopsis
- Autism spectrum disorder (ASD) currently has no effective diagnostic or treatment methods, but disruptions in gut microbiota have been linked to ASD, leading to research into probiotics and dietary changes as potential therapies.
- A study compared the gut microbiomes of children with ASD to typically developing children, identifying unique dysbiosis patterns and assessing the impact of a combined probiotic (Probio-M8) and medium-carbohydrate diet over three months.
- Results indicated that the intervention significantly improved autism symptoms and gastrointestinal health, with corresponding positive changes in gut bacteria and associated metabolites, suggesting that this approach could be a valuable addition to ASD treatment options.
polysaccharide ameliorates the accumulation of lipid droplets in adipose tissue via an ATF6/SIRT1-dependent mechanism.
Acta Biochim Biophys Sin (Shanghai)
June 2024
Lipid droplets (LDs) are dynamic organelles that store neutral lipids and are closely linked to obesity. Previous studies have suggested that polysaccharide (LBP) supplements can ameliorate obesity, but the underlying mechanisms remain unclear. In this study, we hypothesize that LBP alleviates LD accumulation in adipose tissue (AT) by inhibiting fat-specific protein 27 (Fsp27) through an activating transcription factor-6 (ATF6)/small-molecule sirtuin 1 (SIRT1)-dependent mechanism.
View Article and Find Full Text PDFBackground: Mesenchymal stem cell (MSC) therapy has been shown to have some therapeutic effects in rodent models and patients with IBD; however, its role in colon tumor models is controversial. In this study, the potential role and mechanisms of bone marrow-derived MSCs (BM-MSCs) in colitis-associated colon cancer (CAC) were investigated.
Methods: The CAC mouse model was established with azoxymethane (AOM) and dextran sulfate sodium (DSS).
Background And Study Aims: Previous studies have identified that colorectal cancer has different fucosylation levels compared to the normal colon. Ulex europaeus agglutinin-I (UEA-I), which specifically combines with α1-2 fucose glycan, is usually used to detect fucosylation levels. Therefore, we used confocal laser endomicroscopy (CLE) to investigate fluorescently labeled UEA-Fluorescein isothiocyanate (FITC) for detecting colonic cancer.
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