Effect of injury-curing cataplasma on expression of AQP3 in skeletal muscles of rats by regulating cAMP-PKA signal pathway.

Curing-injury Cataplasma to promote regulatory mechanism of acute closed soft tissue injury swelling of rats may be related to inhibit PGE2, regulating the cAMP - PKA signaling pathways, high expression of AQP - 3. SD rats. 48 rats randomly divided into three groups, each group of 16.

Metal-Organic Frameworks@Polymer Composites Containing Cyanines for Near-Infrared Fluorescence Imaging and Photothermal Tumor Therapy.

As a noninvasive treatment method, photothermal therapy (PTT) has been widely investigated for cancer therapy. In this work, metal-organic frameworks@polymer composites (UiO-66@CyP) with bioimaging and PTT activity were prepared by introducing cyanine-containing polymer (CyP) via multicomponent Passerini reaction in the presence of Zr-based nanoscale metal-organic frameworks (UiO-66). As-prepared UiO-66@CyP not only possesses uniformed size, controllable morphology, and excellent dispersibility in aqueous media, but also indicates strong near-infrared absorption and high photothermal conversion efficiency.

The effect of crude drugs on the angiogenic property and dynamic viscoelasticity of PEMA-based soft polymer materials.

This study aimed to determine the effect of crude drugs on the dynamic viscoelasticity and angiogenic property of soft polymer materials, in vitro. Two kinds of polyethyl methacrylates, and crude drugs (Astragalus membranaceus Bunge [HQ] and Salvia miltiorrhiza Bunge [DS]) were used in their powdered forms. And, acetyl tributyl citrate and ethyl alcohol were used in the liquid form.

Expression levels and clinical significance of hepsin and HMGB1 proteins in cervical carcinoma.

This study assessed the hypothesis that the protein levels of high mobility group box 1 (HMGB1) and hepsin can be used as markers for diagnosis and prognosis in cervical carcinoma. Seventy patients with cervical cancer who were hospitalized in Xuzhou Central Hospital from May 2008 to June 2010 and underwent surgical treatment were selected for the observation group. At the same time, 20 patients with cervical benign lesions who underwent tumor stripping or accessory resection were selected for the control group.

General Strategy toward Dual-Scale-Controlled Metallic Micro-Nano Hybrid Structures with Ultralow Reflectance.

Functional metal surfaces with minimum optical reflection over a broadband spectrum have essential importance for optical and optoelectronic devices. However, the intrinsically large optical impedance mismatch between metals and the free space causes a huge obstacle in achieving such a purpose. We propose and experimentally demonstrate a general pulse injection controlled ultrafast laser direct writing strategy for fabricating highly effective antireflection structures on metal surfaces.

Zeolitic imidazole framework coated Au nanorods for enhanced photothermal therapy and stability.

Metal-Organic Frameworks (MOFs) were exploited to coat Au nanorods (AuNRs) as a hyperthermia agent for enhanced plasmonic photothermal therapy. The utilization of a MOF shell reduces the cytotoxicity of AuNRs and enhances the photothermal transduction efficiency of AuNRs, resulting in the improved phototoxicity of MOF coated AuNRs compared with the unmodified AuNRs.

Biocompatibility of polypropylene mesh scaffold with adipose-derived stem cells.

In this study, we investigated the rejection of the synthetic patch and human tissues in the host. We observed the growth of adipose-derived stem cells (ADSCs) cultured with polypropylene mesh . The results of flow cytometry showed that the expression of CD44, CD73, CD90, CD45, CD14 and CD34 was 98.

Indocyanine green-functionalized bottle brushes of poly(2-oxazoline) on cellulose nanocrystals for photothermal cancer therapy.

Deriving from the most abundant and renewable material, cellulose nanocrystals (CNCs) have drawn increasing attention in nanomedicine as well as other biomedical fields due to their excellent physicochemical properties and unique rod-like geometry. In this work, we report an efficient procedure to create biocompatible poly(2-oxazoline)s with a defined bottle brush architecture on CNCs through UV-induced photopolymerization and subsequent living cationic ring-opening polymerization. Characterization of the poly(2-oxazoline) modified CNCs indicates an improved thermal stability with the crystalline structure as well as the rod-like contour intact.

BODIPY-containing nanoscale metal-organic frameworks as contrast agents for computed tomography.

Nanoscale metal-organic frameworks (NMOFs) maintaining the features of both their bulk MOF analogue and nanoparticle formulation have recently emerged as promising platforms for biomedical imaging and drug delivery. In this work, NMOFs were developed and used as computed tomography (CT) imaging agents. The biocompatibility and CT imaging of iodine-boron-dipyrromethene (BODIPY)-containing MOF nanocrystals, named UiO-PDT, have been studied well in vitro and in vivo.

Low-energy defibrillation research using a rabbit ventricular model: optimizing the potential gradient distribution using multiple epicardial electrodes.

Cardiac potential gradient distribution directly affects defibrillation efficacy, and the electrode configuration that ensures optimal distribution is yet to be determined. In this study, a rabbit ventricular finite element conductor model containing blood perfusion in ventricular cavities was developed. The electric field was solved on the model by using 95% myocardial volume potential gradient higher than 5 V/cm as the successful defibrillation threshold (DFT).

Transverse and Oblique Long Bone Fracture Evaluation by Low Order Ultrasonic Guided Waves: A Simulation Study.

Ultrasonic guided waves have recently been used in fracture evaluation and fracture healing monitoring. An axial transmission technique has been used to quantify the impact of the gap breakage width and fracture angle on the amplitudes of low order guided wave modes 0 and 0 under a 100 kHz narrowband excitation. In our two dimensional finite-difference time-domain (2D-FDTD) simulation, the long bones are modeled as three layers with a soft tissue overlay and marrow underlay.

Theoretical and experimental analysis of amplitude control ablation and bipolar ablation in creating linear lesion and discrete lesions for treating atrial fibrillation.

Purpose: Radiofrequency (RF) energy is often used to create a linear lesion or discrete lesions for blocking the accessory conduction pathways for treating atrial fibrillation. By using finite element analysis, we study the ablation effect of amplitude control ablation mode (AcM) and bipolar ablation mode (BiM) in creating a linear lesion and discrete lesions in a 5-mm-thick atrial wall; particularly, the characteristic of lesion shape has been investigated in amplitude control ablation.

Materials And Methods: Computer models of multipolar catheter were developed to study the lesion dimensions in atrial walls created through AcM, BiM and special electrodes activated ablation methods in AcM and BiM.

Factors Related with CH4 and N2O Emissions from a Paddy Field: Clues for Management implications.

Paddy fields are major sources of global atmospheric greenhouse gases, including methane (CH4) and nitrous oxide (N2O). The different phases previous to emission (production, transport, diffusion, dissolution in pore water and ebullition) despite well-established have rarely been measured in field conditions. We examined them and their relationships with temperature, soil traits and plant biomass in a paddy field in Fujian, southeastern China.

Establishing and Understanding Adsorption-Energy Scaling Relations with Negative Slopes.

Adsorption-energy scaling relations are widely used for the design of catalytic materials. To date, only linear scaling relations are known in which the slopes are positive. Considering the adsorption energies of F, O, N, C, and B on transition metals, we show here that scaling relations with negative slopes also exist between certain adsorbates.

Multichannel processing for dispersion curves extraction of ultrasonic axial-transmission signals: Comparisons and case studies.

Some pioneering studies have shown the clinical feasibility of long bones evaluation using ultrasonic guided waves. Such a strategy is typically designed to determine the dispersion information of the guided modes to infer the elastic and structural characteristics of cortical bone. However, there are still some challenges to extract multimode dispersion curves due to many practical limitations, e.

Nanoscale Fluorescent Metal-Organic Framework@Microporous Organic Polymer Composites for Enhanced Intracellular Uptake and Bioimaging.

Polymer-modified metal-organic frameworks combine the advantages of both soft polymers and crystalline metal-organic frameworks (MOFs). It is a big challenge to develop simple methods for surface modification of MOFs. In this work, MOF@microporous organic polymer (MOP) hybrid nanoparticles (UNP) have been synthesized by epitaxial growth of luminescent boron-dipyrromethene (BODIPYs)-imine MOPs on the surface of UiO-MOF seeds, which exhibit low cytotoxicity, smaller size distribution, well-retained pore integrity, and available functional sites.

Estimating ground-level PM concentrations in Beijing, China using aerosol optical depth and parameters of the temperature inversion layer.

The aerosol optical depth (AOD) is widely used to predict surface PM (particles with an aerodynamic diameter smaller than 2.5μm) concentrations using regression methods, as a way to supplement observations from sparse ground PM monitoring networks. Several meteorological parameters, such as surface humidity, temperature and height of planetary boundary layer (HPBL), are usually combined with AOD to improve the accuracy of the regression model in predicting PM concentrations.

Nanoscale Polymer Metal-Organic Framework Hybrids for Effective Photothermal Therapy of Colon Cancers.

A UiO-66 core with various sizes acts as heterogeneous nucleation center and enables aniline polymerization under ambient conditions. The as-synthesized UiO-66@PAN possesses uniform size and excellent dispersibility in aqueous solution. UiO-66@PAN can be internalized by cancer cells via endocytosis, and indicates significant photothermal therapeutic effect in vitro, and can effectively inhibit the growth of colon cancers in vivo.

Measurement of the Human Calcaneus In Vivo Using Ultrasonic Backscatter Spectral Centroid Shift.

Objectives: The aim of this study was to determine the relationship between the backscattered spectral centroid shift and the bone mineral density (BMD) in vivo and investigate the feasibility of using the backscattered spectral centroid shift to characterize the cancellous bone status.

Methods: Ultrasonic backscatter measurements were performed in vivo on 1216 participants at the right calcaneus using an ultrasonic backscattered bone diagnostic system, and the backscattered spectral centroid shift was calculated at central frequencies of 3.5 and 5.

One-Pot To Synthesize Multifunctional Carbon Dots for Near Infrared Fluorescence Imaging and Photothermal Cancer Therapy.

It is an emerging focus to develop a simple and straightforward strategy to synthesize multifunctional nanomedicines for cancer imaging and treatment. In this work, a new carbon dot (named CyCD) with intrinsic theranostic properties was prepared from a hydrophobic cyanine dye [2-((E)-2-((E)-2-chloro-3-((E)-2-(1-(2-hydroxyethyl)-3,3-dimethylindolin-2-ylidene) ethylidene)cyclohex-1-en-1-yl)vinyl)-1-(2-hydroxyethyl)-3,3-dimethyl-3H-indol-1-ium iodide, CyOH] and poly(ethylene glycol) (PEG800) via a simple solvothermal process. The as-prepared CyCD is well dispersed in water media with an average diameter of 2.

Sparse SVD Method for High-Resolution Extraction of the Dispersion Curves of Ultrasonic Guided Waves.

The 2-D Fourier transform analysis of multichannel signals is a straightforward method to extract the dispersion curves of guided modes. Basically, the time signals recorded at several positions along the waveguide are converted to the wavenumber-frequency space, so that the dispersion curves (i.e.

Tetraphenylethylene-based fluorescent coordination polymers for drug delivery.

New tetraphenylethylene immobilized zirconium-based nanoscale coordination polymers (TPE-NCPs) with morphology-dependent and enhanced AIE behavior have been synthesized for the first time. The TPE-NCPs with high crystallization, strong emission and good biocompatibility can be used as a versatile nanoplatform for efficient drug delivery and bioimaging in living cells.

AFM Studies on Liquid Superlubricity between Silica Surfaces Achieved with Surfactant Micelles.

By using atomic force microscopy (AFM), we showed that the liquid superlubricity with a superlow friction coefficient of 0.0007 can be achieved between two silica surfaces lubricated by hexadecyltrimethylammonium bromide (C16TAB) solution. There exists a critical load that the lubrication state translates from superlow friction to high friction reversibly.

Subanesthetic isoflurane relieves zymosan-induced neutrophil inflammatory response by targeting NMDA glutamate receptor and Toll-like receptor 2 signaling.

Neutrophil release of NO/ONOO- induces endothelial cell barrier dysfunction in inflammatory acute lung injury (ALI). Previous studies using zymosan-triggered inflammation and ALI model revealed that zymosan promotes inducible NO synthase (iNOS) expression in neutrophils, and that isoflurane inhibits zymosan-induced oxidative stress and iNOS biosynthesis. However, the underlying mechanisms remain largely unknown.

BODIPY-containing nanoscale metal-organic frameworks for photodynamic therapy.

BODIPY-immobilized zirconium-based nanoscale metal-organic frameworks (MOFs), named , have been synthesized through solvent-assisted ligand exchange using UiO-typed MOFs and pre-designed BODIPY ligands for the first time. The nanocrystal has been proved to possess good biocompatibility and highly efficient generation of singlet oxygen, which could kill the cancer cells effectively.