The RNA mA writer METTL3 in tumor microenvironment: emerging roles and therapeutic implications.

The tumor microenvironment (TME) is a heterogeneous ecosystem comprising cancer cells, immune cells, stromal cells, and various non-cellular components, all of which play critical roles in controlling tumor progression and response to immunotherapies. Methyltransferase-like 3 (METTL3), the core component of -methyladenosine (mA) writer, is frequently associated with abnormalities in the mA epitranscriptome in different cancer types, impacting both cancer cells and the surrounding TME. While the impact of METTL3 on cancer cells has been extensively reviewed, its roles in TME and anti-cancer immunity have not been comprehensively summarized.

Dark transformation from 17β-estradiol to estrone initiated by hydroxyl radical in dissolved organic matter.

The occurrence and fate of 17β-estradiol (E) in natural water have gained extensive attention owing to its high ecotoxic risk to wildlife. Dissolved organic matter (DOM) is a ubiquitous water constituent and contributes significantly to E removal, although the reaction mechanism is rarely clarified. The present study aims to investigate E transformation in water containing fresh or aged DOM surrogates at environmentally relevant concentrations in the dark.

Experimental and theoretical studies into the hydroxyl radical mediated transformation of propylparaben to methylparaben in the presence of dissolved organic matter surrogate.

Dissolved humic and biogenic substances might be present in the aphotic zone and contribute to the fate of parabens in natural aquatic ecosystem under the fluctuation of water multi-parameters. Through the combination of batch tests with quantum chemical calculation, hydroxyl radical (•OH) mediated degradation of propylparaben (PP) to methylparaben (MP) has been confirmed in the present study. The interaction of dissolved oxygen with environmental relevant concentration of humic acid (HA), algal and bacterial cell lysis leads to a slow production of •OH.

Whole genome sequencing of NDM-1-producing serotype K1 ST23 hypervirulent Klebsiella pneumoniae in China.

Purpose: The emergence and spread of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) is causing worldwide concern, whereas NDM-producing hvKP is still rare. Here we report the complete genome sequence characteristics of an NDM-1-producing ST23 type clinical hvKP in PR China.

Methodology: Capsular polysaccharide serotyping was performed by PCR.

Contributions of Abiotic and Biotic Processes to the Aerobic Removal of Phenolic Endocrine-Disrupting Chemicals in a Simulated Estuarine Aquatic Environment.

The contributions of abiotic and biotic processes in an estuarine aquatic environment to the removal of four phenolic endocrine-disrupting chemicals (EDCs) were evaluated through simulated batch reactors containing water-only or water-sediment collected from an estuary in South China. More than 90% of the free forms of all four spiked EDCs were removed from these reactors at the end of 28 days under aerobic conditions, with the half-life of 17α-ethynylestradiol (EE2) longer than those of propylparaben (PP), nonylphenol (NP) and 17β-estradiol (E2). The interaction with dissolved oxygen contributed to NP removal and was enhanced by aeration.