Synthesis and in vitro evaluation of radioiodine labeled hypoxia-targeted drugs containing 2-nitroimidazole and benzenesulfonamide groups.

Designing new radiolabeled hypoxia-targeted drugs is of great help in the diagnosis of tumors. Hypoxia-targeted drugs with dual bioactive groups can enhance hypoxia selectivity, strengthen the binding of drugs to targets, and improve diagnostic accuracy compared with traditional hypoxia-targeted drugs containing only one nitroimidazole group. In this study, a series of novel radioiodine labeled tyrosine derivatives containing 2-nitroimidazole and benzenesulfonamide groups were synthesized and in vitro evaluated.

Interdisciplinary perspectives on diabetes and microcirculatory dysfunction: A global bibliometric analysis.

Background: The prevalence of diabetes and its association with microcirculatory dysfunction presents a significant challenge in contemporary global health. Addressing this nexus is crucial for developing targeted therapeutic interventions.

Aim: To trace the progression and delineate the current state of interdisciplinary research concerning diabetes and microcirculation.

Associations of PM and its components with term preterm rupture of membranes: a retrospective study.

Background: There is evidence that fine particulate matter (PM) exposure is associated with premature rupture of membranes (PROM); however, studies of its effect on term PROM (TPROM) are limited, and the results are inconsistent.

Objective: This study aimed to investigate the association between exposure to PM and its components and the risk of TPROM.

Methods: From 2018 to 2022, we collected delivery data from pregnant women in Guangzhou.

Enantioselective Synthesis of Indole-Fused Polycycles Bearing Four Consecutive Stereocenters via Rhodium Catalysis.

Indole-fused polycycles are common in natural products and bioactive molecules, yet their concise and efficient synthesis remains challenging, especially for compounds with multiple stereocenters. Herein, we report the application of a chiral CpRh catalyst in the enantioselective C-H activation/[4+2] annulation of indoles with bicyclic alkenes. This chiral catalytic system exhibits high enantioselectivity and broad functional group tolerance and operates under benign conditions.

The effect of air pollution exposure on foetal growth restriction in pregnant women who conceived by in vitro fertilisation a cross-sectional study.

Studies investigating the relationship between exposure to air pollutants during pregnancy and foetal growth restriction (FGR) in women who conceive by in vitro fertilisation (IVF) are lacking. The objective was to investigate the effect of air pollutant exposure in pregnancy on FGR in pregnant women who conceive by IVF. We included pregnant women who conceived by IVF and delivered healthy singleton babies in Guangzhou from October 2018 to September 2023.

Enhancing Diagnostic Accuracy of Lung Nodules in Chest Computed Tomography Using Artificial Intelligence: Retrospective Analysis.

Background: Uncertainty in the diagnosis of lung nodules is a challenge for both patients and physicians. Artificial intelligence (AI) systems are increasingly being integrated into medical imaging to assist diagnostic procedures. However, the accuracy of AI systems in identifying and measuring lung nodules on chest computed tomography (CT) scans remains unclear, which requires further evaluation.

In Situ Anchoring Functional Molecules to Polymer Chains Through Supramolecular Interactions for a Robust and Self-Healing Multifunctional Waterborne Polyurethane.

Nowadays, much attention is paid to the development of high-performance and multifunctional materials, but it is still a great challenge to obtain polymer materials with high mechanical properties, high self-healing properties, and multifunctionality in one. Herein, an innovative strategy is proposed to obtain a satisfactory waterborne polyurethane (PMWPU-Bx) by in situ anchoring 3-aminophenylboronic acid (3-APBA) in a pyrene-capped waterborne polyurethane (PMWPU) via supramolecular interactions. The multiple functional sites inherent in 3-APBA can produce supramolecular interactions with groups on PMWPU, promoting the aggregation of hard domains in the polymer network, which confers the PMWPU-Bx strength (7.

Activated hepatic stellate cell-derived small extracellular vesicles facilitate M2 macrophage polarization and hepatoma progression via miR-27a-3p.

The progression of hepatoma is heavily influenced by the microenvironment. Tumor-associated macrophages (TAMs) are considered to play a critical role in the tumor microenvironment (TME) and increase the aggressiveness of hepatoma. The activation of hepatic stellate cells (HSCs) is involved in hepatoma progression, and accumulating evidence demonstrates a change in microRNA (miRNA) expression during HSC activation.

Study on the formation mechanism and effective manipulation of polymorphs and solvates in Osimertinib-Caffeic acid multi-component crystal with distinct properties.

Investigating the formation mechanism and effective manipulation of multi-component crystal polymorphs is crucial for facilitating industrial drug development. Herein, five novel Osimertinib-caffeic acid forms were first strategically tailored by varying solvent selection. Theoretical analysis demonstrated this polymorphism is correlated with multiple hydrogen bond donors-acceptors within multi-component system, which provides manipulation space for reconfiguration of intermolecular interactions and structural competition, while solvent further induced or involved in hydrogen-bonded rearrangements.

Heterogeneous interfaces in confined microdomains of glycyrrhizic acid for polymorphism selection: Mechanisms and applications.

Understanding the mechanisms of heterogeneous nucleation to improve the precision and applicability of polymorphism selection remains challenging. In this study, the formation of confined microdomains with heterogeneous interfaces in the micelle and gel systems were reported based on the supramolecular self-assembly of glycyrrhizic acid. The polymorph with high-purity preparation of isonicotinamide and nicotinamide was achieved due to the high degree of supersaturation and diverse nucleation pathways.

Two-Dimensional Rare-Earth-Based Half-Metals with Topological Bimerons.

Two-dimensional magnets with spontaneous topological spin textures have important application prospects in highly integrated spintronic devices. However, so far, the predicted two-dimensional magnets with topological spin textures are mainly based on transition metals, and most of them are semiconductors or metals. Here, based on first-principles calculations, we predict two-dimensional rare-earth-based half-metallic monolayer GdAN (A = Ge, Sn), with 100% spin polarization.

The E3 ubiquitin ligase RNF6 facilitates the progression of cervical cancer by inhibiting the Hippo/Yap pathway.

Purpose: Cervical cancer (CC), a significant global health threat, necessitates comprehensive understanding for improved therapeutic interventions. Many research indicates that dysregulation of the Hippo-YAP1 pathway leads to uncontrolled proliferation and invasion of tumor cells, promoting the progression of various cancers. This article aims to elucidate the role of RNF6 in CC and its regulation of the Hippo-YAP1 signaling pathway.

Integrated Deep Learning Model for the Detection, Segmentation, and Morphologic Analysis of Intracranial Aneurysms Using CT Angiography.

Purpose To develop a deep learning model for the morphologic measurement of unruptured intracranial aneurysms (UIAs) based on CT angiography (CTA) data and validate its performance using a multicenter dataset. Materials and Methods In this retrospective study, patients with CTA examinations, including those with and without UIAs, in a tertiary referral hospital from February 2018 to February 2021 were included as the training dataset. Patients with UIAs who underwent CTA at multiple centers between April 2021 and December 2022 were included as the multicenter external testing set.

Direct C-H difluoroallylation of α,β-unsaturated amides and aryl amides by rhodium catalysis.

Herein, we report the first example of Rh-catalyzed C(sp)-H difluoroallylation of α,β-unsaturated amides with 3-bromo-3,3-difluoropropene under mild conditions. The features of this protocol for difluoroallylation are unprecedented vinylic substrates, ethanol as a green solvent, good functional group and air compatibility, and scale-up synthesis with low catalyst loading.

Our experience with a modified prying-up technique for closed reduction of irreducible supracondylar humeral fractures.

Satisfactory reduction of some displaced pediatric supracondylar humerus fractures is not achievable via closed reduction, thus necessitating open procedure, which increases the incidence of complications. Using percutaneous prying-up technique to assist closed reduction may reduce the requirement for transform to an open operation. We retrospectively reviewed displaced pediatric supracondylar humerus fractures treated by the same surgeon from September 2021 to January 2024,with 134 subjects meeting criteria for inclusion.

Evaluating artificial intelligence's role in lung nodule diagnostics: A survey of radiologists in two pilot tertiary hospitals in China.

Objectives: This study assesses the perceptions and attitudes of Chinese radiologists concerning the application of artificial intelligence (AI) in the diagnosis of lung nodules.

Material And Methods: An anonymous questionnaire, consisting of 26 questions addressing the usability of AI systems and comprehensive evaluation of AI technology, was distributed to all radiologists affiliated with Beijing Anzhen Hospital and Beijing Tsinghua Changgung Hospital. The data collection was conducted between July 19, and 21, 2023.

Zearalenone induces liver injury in mice through ferroptosis pathway.

Throughout the world, some foods and feeds commonly consumed by humans and animals are inadvertently contaminated with mycotoxins. Zearalenone (ZEA) is a typical environmental/food contaminant that can cause varying degrees of damage to the body, such as reproductive toxicity, hepatotoxicity, immunotoxicity, etc. It poses a serious threat to the living environment and human and animal health.

SiMix: A domain generalization method for cross-site brain MRI harmonization via site mixing.

Brain magnetic resonance imaging (MRI) is widely used in clinical practice for disease diagnosis. However, MRI scans acquired at different sites can have different appearances due to the difference in the hardware, pulse sequence, and imaging parameter. It is important to reduce or eliminate such cross-site variations with brain MRI harmonization so that downstream image processing and analysis is performed consistently.

Structure Prediction and Protein Engineering Yield New Insights into Microcin J25 Precursor Recognition.

Microcin J25 (MccJ25), a lasso peptide antibiotic with a unique structure that resembles the lariat knot, has been a topic of intense interest since its discovery in 1992. The precursor (McjA) contains a leader and a core segment. McjB is a protease activated upon binding to the leader, and McjC converts the core segment into the mature MccJ25.

The impact of PM and its constituents on gestational diabetes mellitus: a retrospective cohort study.

Background: There is increasing evidence that exposure to PM and its constituents is associated with an increased risk of gestational diabetes mellitus (GDM), but studies on the relationship between exposure to PM constituents and the risk of GDM are still limited.

Methods: A total of 17,855 pregnant women in Guangzhou were recruited for this retrospective cohort study, and the time-varying average concentration method was used to estimate individual exposure to PM and its constituents during pregnancy. Logistic regression was used to assess the relationship between exposure to PM and its constituents and the risk of GDM, and the expected inflection point between exposure to PM and its constituents and the risk of GDM was estimated using logistic regression combined with restricted cubic spline curves.

Cortical Tagged Synaptic Long-Term Depression in the Anterior Cingulate Cortex of Adult Mice.

The anterior cingulate cortex (ACC) is a key cortical region for pain perception and emotion. Different forms of synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD), have been reported in the ACC. Synaptic tagging of LTP plays an important role in hippocampus-related associative memory.

Lactobacillus salivarius ameliorates Mycoplasma gallisepticum-induced inflammation via the JAK/STAT signaling pathway involving respiratory microbiota and metabolites.

Mycoplasma gallisepticum (MG) can cause chronic respiratory disease (CRD) in chickens, which has a significant negative economic impact on the global poultry sector. Respiratory flora is the guardian of respiratory health, and its disorder is closely related to respiratory immunity and respiratory diseases. As a common probiotic in the chicken respiratory tract, Lactobacillus salivarius (L.