Control Intracellular Protein Condensates with Light.

Protein phase transitions are gaining traction among biologists for their wide-ranging roles in biological regulation. However, achieving precise control over these phenomena in vivo remains a formidable task. Optogenetic techniques present us with a potential means to control protein phase behavior with spatiotemporal precision.

In Fanconi anemia, impaired accumulation of bone marrow neutrophils during emergency granulopoiesis induces hematopoietic stem cell stress.

Fanconi anemia (FA) is an inherited disorder of DNA repair due to mutation in one of 20+ interrelated genes that repair intrastrand DNA crosslinks and rescue collapsed or stalled replication forks. The most common hematologic abnormality in FA is anemia, but progression to bone marrow failure (BMF), clonal hematopoiesis, or acute myeloid leukemia may also occur. In prior studies, we found that Fanconi DNA repair is required for successful emergency granulopoiesis; the process for rapid neutrophil production during the innate immune response.

A highly birefringent metal-free crystal assembled by cooperative non-covalent interactions.

Birefringent crystals can manipulate the phase and polarization of light, so they are widely used as essential components in various optical devices. Common strategies to construct birefringent crystals are introducing metal cations that are either able to realize favorable coordination with functional anionic units or are susceptible to polarizability anisotropy. Herein, we report a metal-free crystal, NH(HCNO)·2HO, synthesized using the facile solution method.

Deep-Ultraviolet Bialkali-Rare Earth Metal Anhydrous Sulfate Birefringent Crystal.

Birefringence is an important linear optical property of anisotropic crystals that plays a significant role in regulating light polarization. A new bialkali-rare earth metal sulfate, NaRbY(SO) compound, consisting of non-π-conjugated alkali metals and rare earth metal-centered dodecahedral YO has been synthesized. The structure analysis suggests that the three-dimensional (3D) structure of the compound is found to be attributable to the combination of dodecahedral YO and tetrahedral SO groups with Na and Rb located in the cavities.

Research space telescope deployable mechanism variable diameter internal drive device elastic collision contact characteristics in the inter-stage transition.

To address the problem of elastic contact discrepancies between a variable-diameter internal drive device and a non-continuous surface during the transition, caused by the vibrations resulting from elastic collision impact when the motion speed of the elastic body increases, the following steps were taken. First, we established models for elastic collision, impact, and vibration during the inter-stage transition to analyze how motion speed and preload affect the elastic contact characteristics between the two components. Subsequently, we employed the finite element method to further analyze the elastic contact state, using identical loads but varying motion speeds and radial preloads as boundary conditions.

Designing a Hybrid Perovskite with Enlarged Birefringence and Bandgap for Modulation of Light Polarization.

Birefringent crystals have important applications in optoelectronics areas due to their ability to modulate and polarize light. Despite increasing discovery of the birefringence potential of new crystals, it remains a great challenge to optimize both birefringence and bandgap simultaneously. Herein, a 1D chain-like hybrid perovskite birefringent crystal designed by 3D-to-1D dimensional tailoring, (GAM) PbI ·H O (GAM = C N H ), is presented, showing enlarged birefringence of 0.

Cutting depth-oriented ductile machining of infrared micro-lens arrays by elliptical vibration cutting.

Infrared micro-lens arrays (MLAs) are widely used in advanced optical systems due to their advantages such as low focusing depth and high sensitivity. Elliptical vibration cutting (EVC) is a promising approach for the fabrication of MLAs on infrared brittle materials. However, the mechanism of ductile machining of MLAs prepared by EVC has not been fully elucidated so far.

A Two-Dimensional Hybrid Perovskite With Heat Switching Birefringence.

Birefringent crystals that can switch light polarization have important applications in optoelectronics. In the last decades, birefringence is mostly optimized by chemical strategies. Recently, switching birefringence by physical means has attracted much attention.

A Non-π-Conjugated Molecular Crystal with Balanced Second-Harmonic Generation, Bandgap, and Birefringence.

Traditional nonlinear optical (NLO) crystals are exclusively limited to ionic crystals with π-conjugated groups and it is a great challenge to achieve a subtle balance between second-harmonic generation, bandgap, and birefringence for them, especially in the deep-UV spectrum region (E  > 6.20 eV). Herein, a non-π-conjugated molecular crystal, NH BH , which realizes such balance with a large second-harmonic generation response (2.

Designing a Dimension Reduced Hybrid Perovskite with Robust Large Birefringence by Expanding Cationic π-Delocation.

It is in great demand to discover new materials with large birefringence for the miniaturization of optical communication devices. In this work, a new one-dimensional hybrid halide perovskite, (C N H )Pb Br , is obtained successfully through structural design of dimension reduction from the notable three-dimensional halide perovskite CsPbBr . Remarkably, (C N H )Pb Br exhibits a significantly enhanced birefringence of ∆n = 0.

Mixed Alkali Metal and Alkaline Earth Metal Scandium Borate Birefringence Material with Layered Structure and Short Ultraviolet Cutoff Edge.

Birefringent crystals are essential in the domains of linear and nonlinear optics that need light wave polarization control. Rare earth borate has become a popular study material for ultraviolet (UV) birefringence crystals due to its short cutoff edge in the UV area. RbBaScBO, a two-dimensional layered structure compound with the BO group, was effectively synthesized through spontaneous crystallization.

Factors and key problems influencing insured's poor perceptions of convenience of basic medical insurance: a mixed methods research of a northern city in China.

Background: This study aimed to explore the factors that affect insured's perceptions of convenience of the basic medical insurance (PCBMI) in Harbin, China and to diagnose the key problems to further propose corresponding measures. The findings provide evidence-based support for the reform of convenience of the basic medical insurance system (BMIS) and the cultivation of public literacy.

Methods: We adopted a mixed methods design composing a multivariate regression model using the data from a cross-sectional questionnaire survey (n = 1045) of residents who were enrolled for BMIS in Harbin to identify the factors influencing the PCBMI.

Nore1 inhibits age-associated myeloid lineage skewing and clonal hematopoiesis but facilitates termination of emergency (stress) granulopoiesis.

Age-associated bone marrow changes include myeloid skewing and mutations that lead to clonal hematopoiesis. Molecular mechanisms for these events are ill defined, but decreased expression of Irf8/Icsbp (interferon regulatory factor 8/interferon consensus sequence binding protein) in aging hematopoietic stem cells may contribute. Irf8 functions as a leukemia suppressor for chronic myeloid leukemia, and young Irf8 mice have neutrophilia with progression to acute myeloid leukemia (AML) with aging.

A Hydrogen Bonded Supramolecular Framework Birefringent Crystal.

Birefringent crystals could modulate the polarization of light and are widely used as polarizers, waveplates, optical isolators, etc. To date, commercial birefringent crystals have been exclusively limited to purely inorganic compounds such as α-BaB O with birefringence of about 0.12.

Perceptions of the benefits of the basic medical insurance system among the insured: a mixed methods research of a northern city in China.

Background: The perceptions of the benefits of the basic medical insurance system among the insured not only reflect the system's performance but also the public's basic medical insurance policy literacy, valuable information for countries that have entered the stage of deepening reform. This study aims to examine the factors that affect the perceptions of the benefits of the basic medical insurance system in China, diagnose the key problems, and propose corresponding measures for improvement.

Methods: A mixed method design was used.

CHNOCd(NO)·2HO: a birefringent crystal with an enlarged band-gap derived from covalent edge-sharing connection.

A new birefringent crystal, CHNOCd(NO)·2HO, was designed by combining a π-conjugated [CHNO] group with a CdON polyhedron. Notably, the experimental energy gap is 0.02 eV higher than that of the organic raw material, which resulted from a covalent edge-sharing connection, implying a new strategy to improve the band-gap of birefringent materials.

A High-Performance Nonlinear Optical Crystal with a Building Block Containing Expanded π-Delocalization.

Common nonlinear optical (NLO) crystals consist of traditional functional building blocks with inherent optical limitation. Herein, inspired by traditional (B O ) inorganic building block, we theoretically identified a new type of organic functional building blocks and then successfully synthesized the first cyamelurate NLO crystal, Ba(H C N O )  ⋅ 8 H O. To our surprise, the constituent (H C N O ) building block is not in structurally optimal arrangement, but Ba(H C N O )  ⋅ 8 H O exhibits excellent optical properties including wide band gap of 4.

Therapeutic strategies for retention of cranioplasty titanium mesh after mesh exposure.

Background: Titanium mesh exposure after cranioplasty is a possible complication and is usually managed by mesh removal and flap transfer, but the advantages of the rigid prosthesis are then lost. This study aimed to present our experience with negative pressure wound therapy combined with soft tissue dilation for retaining the titanium mesh in patients with mesh exposure after cranioplasty.

Methods: This retrospective study included patients treated between 01/2016 and 05/2019 at the Jiangyin Hospital Affiliated to Southeast University School of Medicine.

An Optically Anisotropic Crystal with Large Birefringence Arising from Cooperative π Orbitals.

Birefringent materials are highly demanded for high-performance polarized optics. As compared with artificial anisotropic metamaterials, anisotropic crystals have advantages of low optical losses and easy processing, but their birefringence is still limited. Herein, based on first-principles studies, we identified a new type of functional anion units, (H C N ) (x=0, 1, 2), and then successfully synthesized a new anisotropic crystal, namely, CsH C N ⋅H O (I), whose crystal structure consists of (H C N ) anions.

CASM-AMFMNet: A Network Based on Coordinate Attention Shuffle Mechanism and Asymmetric Multi-Scale Fusion Module for Classification of Grape Leaf Diseases.

Grape disease is a significant contributory factor to the decline in grape yield, typically affecting the leaves first. Efficient identification of grape leaf diseases remains a critical unmet need. To mitigate background interference in grape leaf feature extraction and improve the ability to extract small disease spots, by combining the characteristic features of grape leaf diseases, we developed a novel method for disease recognition and classification in this study.

A Hybrid Halide Perovskite Birefringent Crystal.

Birefringent crystals that can modulate the polarization of light play a significant role in modern optical devices including polarizing microscopes, optical isolators, and achromatic quarter-wave plates. To date, commercial birefringent crystals are exclusively limited to purely inorganic compounds. Here we report a new organic-inorganic hybrid halide, MLAPbBr (MLA=melamine), which features a (110)-oriented layered perovskite structure.

Topical Application of Tranexamic Acid Can Reduce Postoperative Blood Loss in Calcaneal Fractures: A Randomized Controlled Trial.

The traditional lateral "L" approach is common for managing calcaneal fractures with a drawback of significant blood loss. Yet there are no prospective studies on the hemostatic effect of the topical use of tranexamic acid (TXA) in calcaneal fracture surgeries. The purpose of this study was to evaluate the role of topical administration of TXA in reducing postoperative blood loss in calcaneal fractures.

A New Nonlinear Optical Material with N(CN) Anion.

Discovering new functional genes and developing high-performance materials are the goals being pursued by scientists. In this work, we successfully obtained a second-order nonlinear optical (NLO) material via the aqueous solution method, Y[N(CN) ] [NH(C H ) ] ⋅ 3H O, which is the first NLO material with the anionic group N(CN) . Remarkably, this material is not only strongly NLO-active at 1064 nm with a response of about 2.

LRTM effect and electronic crystal imaging on silicon surface.

Some interesting phenomena have been observed in the laser reflecting Talbot magnification (LRTM) effect discovered at first, in which the high-order nonlinear imaging and the plasmonic structures imaging occur. The LRTM effect images were obtained on the 1D and 2D photonic crystals fabricated by using nanosecond pulsed laser etching on silicon surface, where the high-order nonlinear imaging on the 1D and 2D photonic crystals was observed interestingly. The theory result is consistent with the experimental one, which exhibits that the suitable wave-front shape of injection beam selected in optical route can effectively enlarge the magnification rate and elevate the resolution of the Talbot image.