Publications by authors named "Weiqi Cui"

Article Synopsis
  • - The study investigates the protective effects of Artemisia argyi essential oil (AAEO) against liver damage caused by acetaminophen (APAP) in mice, as APAP is known to induce hepatotoxicity.
  • - Through various methods, including liver enzyme analysis and metabolic profiling, researchers found that AAEO mitigates liver damage by enhancing antioxidant activity and regulating liver metabolism.
  • - Results indicated that AAEO helps reduce harmful levels of APAP in the liver by promoting the synthesis of glutathione (GSH), which helps detoxify the liver and prevent further damage.
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The state-of-the-art triboelectric nanogenerator (TENG) technology has numerous advantages and creates new prospects for the rapid development of the Internet of Things (IoT) in marine environments. Here, to accelerate the application process of TENG, an elaborately designed multilayered sleeve-structured hybrid nanogenerator (M-HNG) is developed to efficiently and persistently harvest marine energy. The M-HNG integrates an electromagnetic nanogenerator (EMG) with four coils and a multilayered sleeve-structured TENG (MS-TENG) with three freestanding layer units to increase spatial utilization efficiency.

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Coronary spastic angina (CSA) is common, and treatment options for refractory vasospastic angina are sometimes limited. Guizhifuling pills (GFP) have demonstrated efficacy in reducing CSA episodes, but their pharmacological mechanism remains unclear. To explore the mechanism of action of GFP in preventing and treating CSA, we employed network pharmacology and molecular docking to predict targets and analyze networks.

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To achieve large-scale development of triboelectric nanogenerators (TENGs) for water wave energy harvesting and powering the colossal sensors widely distributed in the ocean, facile and scalable TENGs with high output are urgently required. Here, an elastic self-recovering hybrid nanogenerator (ES-HNG) is proposed for water wave energy harvesting and marine environmental monitoring. The elastic skeletal support of the ES-HNG is manufactured using three-dimensional (3D) printing technology, which is more conducive to the large-scale integration of the ES-HNG.

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Hybrid nanogenerators (HNGs) represent a promising avenue for water energy harvesting, yet their commercial viability faces hurdles such as limited power output, poor coupling, and constrained operational lifespans. Here, a highly coupled triboelectric-electromagnetic magnetic-levitation hybrid nanogenerator (ML-HNG) is introduced that shows great potential for water energy harvesting. The ML-HNG fulfills the challenges of high power output, strong coupling, and long operational lifespans.

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The environmental pollutant bisphenol A (BPA), used in the manufacture of plastic packaging materials for various diets, is widely distributed in the environment and causes severe hepatotoxicity by inducing oxidative stress. Artemisia argyi essential oil (AAEO), a volatile oil component isolated from Artemisia argyi H.Lév.

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Artemisia argyi H.Lév. & Vaniot, a traditional Chinese medicine with a history spanning over two millennia, has been extensively used in folk medicine to treat dysmenorrhea, uterine bleeding and inflammation.

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This work aims to elucidate the molecular mechanism of Qi Wei anti-burn Tincture (QW) on wound healing in burnt mice using metabolomics and molecular biology techniques. A scald model was first established in Kunming mice. After treatment, biochemical indicators for liver function and burnt skin tissues were then evaluated via biochemical detection and HE staining, respectively.

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Article Synopsis
  • A stable isotope labeling-flow injection analysis-tandem mass spectrometry (SIL-FIA-MS/MS) method was developed for quickly and accurately detecting anabolic-androgenic steroids (AAS) in food.
  • A rapid sample preparation process included simple centrifugation for liquids and solid-liquid extraction for solids, allowing detection times of less than 1 minute per sample.
  • The method demonstrated improved detection sensitivity (2-5 times better), accurate quantitative analysis with minimal matrix effects, and robust validation, making it superior to previous detection methods.
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Background: Pancreatic cancer is one of the most common malignant tumors of the digestive tract. Ponicidin, a tetracyclic diterpenoid active ingredient extracted from the traditional phytomedicine Rubescens, has high safety and great inhibitory effect on the proliferation of a variety of cancer cells, especially malignant tumor cells of the digestive tract. However, the inhibitory effect and mechanism of ponicidin on pancreatic cancer cells is still unclear.

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The current study presents a convenient, rapid and effective simultaneous extraction/derivatization (SEDP) strategy for effective pretreatment of catecholamines (CAs). Commercial zirconium oxide (ZrO) nanoparticles were employed for the selective capturing of cis-diol containing CAs to remove the biological interferences and phenyl isothiocyanate (PITC) was used for derivatization to improve the ionization and to improve the chromatographic separation. The extraction and derivatization procedures were integrated into one step to simplify the sample pretreatment.

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Doxorubicin (Dox) is commonly used for the treatment of malignant tumors, including colon cancer. However, the development of P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) in tumor chemotherapy has seriously reduced the therapeutic efficacy of Dox. Natural product curcumin (Cur) was demonstrated to have a variety of pharmacological effects, such as anti-tumor, anti-oxidation and anti-aging activities.

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Bisphenol A (BPA) is widely used to manufacture packaging materials for various daily necessities and causes harmful effects in organs, especially liver injury, by generating oxidative stress. Oridonin, an active diterpenoid isolated from Rabdosia rubescens (Hemsl.) Hara, has been reported to possess a wide range of pharmacological activities including anti-inflammatory, antioxidative and antiapoptotic effects.

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Human exposure to bisphenol A (BPA) is unavoidable in daily life. Recently, research has showen that BPA could induce oxidative imbalance, thereby causing reproductive toxicity and liver dysfunction. Accumulated evidence has demonstrated that metformin possesses strong anti-oxidative properties.

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Tau is a microtubule-associated protein and expressed in normal breast epithelial cells and breast cancer. Tau expression in breast cancer may be important for chemotherapy optimization. This study is to investigate the expression of Tau in advanced breast cancer and its significance in taxane-containing neoadjuvant chemotherapy.

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Synopsis of recent research by authors named "Weiqi Cui"

  • - Weiqi Cui's recent research primarily focuses on the utilization of traditional medicinal plants, specifically
  • Artemisia argyi
  • , to address various health issues, including hepatotoxicity, as evidenced by multiple studies exploring the effects of its essential oil on liver injury induced by acetaminophen and bisphenol A.
  • - In the field of engineering, Cui has made significant advancements in energy harvesting technologies, particularly through the development of hybrid nanogenerators designed to efficiently gather marine energy and support environmental monitoring, showcasing innovative designs like the multilayered sleeve-structured hybrid nanogenerator and the elastic self-recovering hybrid nanogenerator.
  • - Cui's investigation into complex systems also includes the application of network pharmacology and molecular docking to understand the mechanisms of Traditional Chinese Medicine, such as
  • Guizhifuling pills
  • , in treating coronary spastic angina, highlighting an interdisciplinary approach that combines pharmacology with modern bioscience.

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