Accuracy of antibiotic concentrations in drug dispensing in neonates: a laboratory-based study.

Background: Antibacterial therapy plays a crucial role in neonatal infections. The efficacy of antibacterial agents is closely related to the actual dose given to neonates. So we evaluated factors potentially affecting the actual dose of intravenous antibiotics during dispensing process in neonates.

Predicting Model of Biochemical Recurrence of Prostate Carcinoma (PCa-BCR) Using MR Perfusion-Weighted Imaging-Based Radiomics.

Objective: To build a combined model that integrates clinical data, contrast-enhanced ultrasound, and magnetic resonance perfusion-weighted imaging-based radiomics for predicting the possibility of biochemical recurrence of prostate carcinoma and develop a nomogram tool.

Method: We retrospectively analyzed the clinical, ultrasound, and magnetic resonance imaging data of 206 patients pathologically confirmed with prostate carcinoma and receiving radical prostatectomy at Xiangyang No. 1 People's Hospital from February 2015 to August 2021.

The role and possible molecular mechanism of valproic acid in the growth of MCF-7 breast cancer cells.

Aim: To investigate the role of valproic acid (VPA), a class I selective histone deacetylase inhibitor, on Michigan Cancer Foundation (MCF)-7 breast cancer cells, named and explore its possible molecular mechanism.

Methods: MCF-7 cells were cultured with sodium valproate (0. 5-4.

Update on administration of anesthetics and psychoactive drugs for pain management in China.

Anesthetics and psychoactive drugs could relieve diseases, if used properly. However, they can cause dependency, and their misuse or abuse could adversely affect people's health and social stability. For a long time, the Chinese government has been reinforcing the regulation on anesthetics and psychoactive drugs to ensure their legal and proper usage, and to prevent abuse.

Efficacy of biofeedback therapy via a mini wireless device on sleep bruxism contrasted with occlusal splint: a pilot study.

The putative causes of bruxism are multifactorial and there are no definite measures for bruxism management. The aim of this study was to evaluate the efficacy of biofeedback therapy on sleep bruxism, compared with occlusal splint. Twenty-four volunteers with sleep bruxism were divided into two groups: the GTB group that were treated with biofeedback therapy (n  = 12) and the GTO group that were treated with occlusal splint (n  = 12).

Effect of different coping designs on all-ceramic crown stress distribution: a finite element analysis.

Objective: To investigate the effect of differential coping designs on the stress distributions of an all-ceramic crown on, the upper central incisor under varying loads.

Methods: 3D finite element models with three differential coping designs of an all-ceramic crown on, the upper central incisor were constructed using CAD (computer aided design) software. The coping, designs included: CC (conventional coping), MCL (modified coping without veneer coverage in lingual, surface) and MCM (modified coping without veneer coverage in lingual margin).

[Preliminary study of wireless biofeedback therapy for treatment of bruxism].

Objective: To access the effect of wireless biofeedback therapy on bruxism.

Methods: Ten voluntary bruxers (seven female and three male, mean age 26.1 years) were invited to participate in this clinical research.

[Finite element stress analysis of all-ceramic crown of the upper central incisor in differential thickness].

Objective: To investigate the stress distributions under load in an all-ceramic crown of the upper central incisor in differential thickness.

Methods: The 3-dimensional finite element model of all-ceramic crown of the upper central incisor in differential thickness was applied with differential loads (100, 150, 200 N). The stress values and distributions of all-ceramic crown were calculated and expressed.

Colon-specific delivery tablets of sodium 4-aminosalicylic acid.

Aim: To prepare a new oral colon-specific delivery formulation and to investigate the release profile in vitro and the colon-specific delivery property in vivo in dogs.

Methods: Sodium 4-aminosalicylic acid was selected as the model drug. The combination of Eudragit RL30D and RS30D were used as sustained-release film, and Eudragit FS30D used as enteric film, which was expected to release drug depending on pH and time.