From Theory to Practice: Mitigating the Harm of Online Harassment in Public Health.

This article uses the theoretical framework of the networked public to understand the dynamics of online harassment of public health professionals. Coauthors draw on their experiences with health communication on social media, in a local public health department, and in news media to illustrate the utility of this framework. Their stories also highlight the need to build a more proactive approach to online harassment in public health.

Cellular Transcriptomics of Carboplatin Resistance in a Metastatic Canine Osteosarcoma Cell Line.

Osteosarcoma prognosis has remained unchanged for the past three decades. In both humans and canines, treatment is limited to excision, radiation, and chemotherapy. Chemoresistance is the primary cause of treatment failure, and the trajectory of tumor evolution while under selective pressure from treatment is thought to be the major contributing factor in both species.

Canine osteosarcoma cells exhibit basal accumulation of multiple chaperone proteins and are sensitive to small molecule inhibitors of GRP78 and heat shock protein function.

Osteosarcoma is the most common type of bone cancer in dogs and humans, with significant numbers of patients experiencing treatment failure and disease progression. In our search for new approaches to treat osteosarcoma, we previously detected multiple chaperone proteins in the surface-exposed proteome of canine osteosarcoma cells. In the present study, we characterized expression of representative chaperones and find evidence for stress adaptation in canine osteosarcoma cells relative to osteogenic progenitors from normal bone.

Exosomal proteomic signatures correlate with drug resistance and carboplatin treatment outcome in a spontaneous model of canine osteosarcoma.

Background: Osteosarcoma patients often experience poor outcomes despite chemotherapy treatment, likely due in part to various mechanisms of tumor cell innate and/or acquired drug resistance. Exosomes, microvesicles secreted by cells, have been shown to play a role in drug resistance, but a comprehensive protein signature relating to osteosarcoma carboplatin resistance has not been fully characterized.

Methods: In this study, cell lysates and exosomes from two derivatives (HMPOS-2.

Autocrine production of reproductive axis neuropeptides affects proliferation of canine osteosarcoma in vitro.

Background: Osteosarcoma strikes hundreds of people each year, of both advanced and younger ages, and is often terminal. Like many tumor types, these bone tumors will frequently undergo a neuroendocrine transition, utilizing autocrine and/or paracrine hormones as growth factors and/or promoters of angiogenesis to facilitate progression and metastasis. While many of these factors and their actions on tumor growth are characterized, some tumor-derived neuropeptides remain unexplored.

HIV risk perceptions among adolescents attending family planning clinics: an integrated perspective.

Abstract The current study assessed the impact of individual, interpersonal, and contextual factors on HIV risk perception. A total of 426 female adolescents attending family planning clinics took part in this study. The majority, 60.

Ethnicity as a factor in reproductive health care utilization among males attending family planning clinics.

Health care utilization of reproductive health care services among males is an emerging issue. This study examined ethnicity as a factor in reproductive health care utilization among 1,606 African American and Hispanic young males attending family planning clinics. Seventy percent were African American and 30% were Hispanic.

Mental health screening in family-planning clinics: a sexual risk-reduction opportunity.

This study examined the association between depression, risk behaviors, parental communication, and perceived barriers related to condom use among adolescents attending family-planning clinics. A total of 751 minority women participated in the study. The authors collected data on demographic characteristics, depression, risk behaviors, parental communication about sex-related topics, and perceptions about partner attitudes.

Parental communication as a protective factor in increasing condom use among minority adolescents.

The purpose of this study was to examine ethnic differences in risk behaviors among adolescents who attended family planning clinics and to evaluate the impact of parental communication regarding sexual topics on adolescent condom use. The sample for this study included 697 black and Hispanic female adolescents ranging in age from 13-22 years. Ethnic differences were found in sexually transmitted infection rates, number of sexual partners, and condom use.

Ethnic and Marital Differences in Family Structure, Risk Behaviors, and Service Requests Among Young Minority Fathers.

The purpose of this study was to examine ethnic and marital status differences in family structure, risk behaviors and service requests among African American and Hispanic adolescent fathers participating in a community-based fatherhood program. Demographic factors, risk behaviors, and service requests were gathered at program entry. The results indicated that each group demonstrated distinct patterns associated with family structure, sexual risk behaviors, substance use, and criminal behavior.

The relationship between adolescent depression and a history of sexual abuse.

The purpose of this study was to examine the occurrence of depression among adolescents attending family planning clinics, and to determine the relationship among depression, a history of sexual abuse, and other risk behaviors. The sample consisted of 279 minority females. Results of the study indicated that 40 adolescents (14.

The nature of connections: young fathers and their children.

The purpose of this study was to examine the involvement of young fathers with their children at entry to a fatherhood program and at subsequent follow-up. Thirty-eight young fathers participated in this analysis. Using open-ended questions at intake and subsequent follow-up, they were asked to describe in their own words their relationships with their children.

HIV testing and counseling among adolescents attending family planning clinics.

This study examined whether an assessment tool combining HIV-related risk behaviors and symptoms would increase HIV testing and return for post-test counseling among 466 adolescents attending family planning clinics. The results indicted that high-risk behaviors were common among these adolescents. The majority (78.

Internet dependence in the collegiate population: the role of shyness.

Low sensation seeking and loneliness have been associated with collegiate Internet dependence. In an attempt to further explicate the factors associated with collegiate Internet dependence, interpersonal shyness (both online and in face-to-face [FTF] interactions) was explored. An online questionnaire was used to assess Internet dependency and shyness.

Associations of family support, resiliency, and depression symptoms among indigent teens attending a family planning clinic.

The goal of this study was to examine the effect of resiliency and family support on depression symptoms among 110 indigent adolescents attending a family planning clinic in a large urban city in southwestern USA. Findings suggested that several of the resiliency domains, on the Individual Protective Factors Index, as well as family support measured by the Family Support Scale, were associated with depression symptoms. Scores on the self-concept and positive outlook dimensions of the Personal Competence domain, the confidence and assertiveness dimensions of the Social Competence domain, and family support correlated with depression symptoms.

Mental health problems and symptoms among male adolescents attending a teen health clinic.

The purpose of this study was to examine the frequency and nature of mental health problems and symptoms among a group of 51 inner-city male adolescents attending a teen health clinic at a large county hospital in the southwestern part of the United States. They were administered a problem area checklist and a problem symptom checklist. The problem area checklist covered a range of mental health issues, including peer/friendship, relationship, and family problems; problems with money, time, and the law; substance use; and eating disorders.

Social work intervention and failure to thrive in infants and children.

Failure to thrive (FTT) is a diagnostic term used to describe infants and children who fail to grow and develop at a normal rate. There has been limited literature focused on the role social workers play in working with children who fail to thrive. Because the focus of the current health care system is on using an interdisciplinary team approach, it is crucial that social workers make a place for themselves on treatment teams and continue to use their skills to provide comprehensive treatment.

Opportunities for pregnant and parenting teenagers: a school-based and school-linked intervention program.

Three hundred and ninety (390) pregnant and parenting teens participated in a school-based and school-linked federally funded program at 10 high-risk schools. The program was designed to (1) increase the use of referred services and attendance at these services without students' missing school, (2) increase academic skills, and (3) increase health and well-being of the students and their infants. The program provided 18 services coordinated at the school or provided on site.