Publications by authors named "Weinian Liu"

Article Synopsis
  • The study investigates the effects of Curcumenol, a compound from traditional Chinese medicine, on cartilage metabolism dysregulation in knee osteoarthritis (KOA), aiming to clarify its mechanisms of action through advanced techniques like transcriptomics and metabolomics.
  • Using a mouse model of KOA, the researchers administered different doses of Curcumenol and employed various methods to assess its impact on cartilage health and cellular functions.
  • Results showed that Curcumenol reduced cartilage damage, enhanced cartilage repair, and positively influenced extracellular matrix metabolism by regulating specific proteins associated with cartilage health.
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Alzheimer's disease (AD) and osteoarthritis (OA) are both senile degenerative diseases. Clinical studies have found that OA patients have a significantly increased risk of AD in their later life. This study hypothesized that chronic aseptic inflammation might lead to AD in KOA patients.

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Objective: The aim of this study was to investigate the clinical efficacy of closed manipulation combined with splinting in the treatment of displaced distal radial and ulnar fractures in children.

Methods: A total of 82 children with displaced fractures of the distal radial and ulnar segment who met the inclusion criteria and were treated as outpatients or inpatients in the orthopedic department of Guangzhou Orthopedic Hospital, from January 2016 to June 2022 were randomly divided into an observation group and a control group: 41 children in the observation group were treated with closed manipulation combined with splint fixation; 41 children in the control group were fixed with incisional repositioning elastic nails combined with internal plates. The Anderson efficacy grading, visual analog scale (VAS) score, fracture healing time, treatment cost, hospital days, and complications were observed and compared between the two groups.

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Background: Knee osteoarthritis (KOA) is an age-related degenerative disease characterized by abrasion of articular cartilage. Tongbi Huoluo Decoction (TBHLD) has been transformed from the famous traditional Chinese medicine Duhuo Jisheng Decoction, which can effectively alleviate pain symptoms in KOA. However, the active components and mechanisms of TBHLD in treating KOA have not yet been elucidated.

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Osteoporotic fracture (OPF) is a prevalent skeletal disease in the middle-aged and elderly. In clinical practice, Jianshen Decoction (JSD) has been used to treat OPFs. However, the specific effective components and mechanisms of JSD on OPF have not been explored.

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