A simple AIE-based indole-benzimidazole probe for the ratiometric fluorescent detection of phosgene in an almost neat aqueous solution.

Phosgene is a suffocating toxic gas that seriously threatens human health and public security. With this research, we developed a simple ratiometric fluorescent probe (1) bearing indole and benzimidazole moieties as the sensing sites and employed it for the aggregation-induced emission-based (AIE-based) detection of phosgene. It was the first time that the probe could detect phosgene in an almost pure aqueous solution (f = 99.

Cervical cancer diagnosis model using spontaneous Raman and Coherent anti-Stokes Raman spectroscopy with artificial intelligence.

Cervical cancer is the fourth most common cancer worldwide. Histopathology, which is currently considered the gold standard for cervical cancer diagnosis, can be time-consuming and subjective. Therefore, there is an urgent need for a rapid, objective, and non-destructive cervical cancer detection technique.

Multibranched flower-like ZnO anchored on pectin/cellulose nanofiber aerogel skeleton for enhanced comprehensive antibacterial capabilities.

In this study, F-ZnO NPs were used as antibacterial agents, mussel bionic dopamine exerted its adhesive action to immobilize F-ZnO NPs on the pectin/CNF aerogel skeleton. Fruit and vegetable antimicrobial mats with safety, long duration of action and high efficiency were prepared and its potential application has been investigated. The results showed that a dopamine layer was deposited on the surface of the CNF, which promoted the tight adhesion of the F-ZnO NPs to the aerogel skeleton.

A dihydro-benzo[4,5]imidazo[1,2-]quinazoline-based probe with aggregation-induced ratiometric emission for the ratiometric fluorescent detection of peroxynitrite in living cells and zebrafish.

As a significant kind of reactive oxygen species (ROS), peroxynitrite (ONOO) plays an indispensable role in many physiological and pathological processes. This study aimed to synthesize a novel dihydro-benzo[4,5]imidazo[1,2-]quinazoline-based probe 1 for detecting ONOO. In 99.

Highly ammonia-responsive starch/PVA film with gas absorption system as the 'bridge' for visually spoilage monitoring of animal-derived food.

In the context of food waste and human diseases caused by food pollution, color renderement intelligent packaging came into being. Improving its indicator stability and sensitivity is essential for application. On the basis of our previous work, corn starch/polyvinyl alcohol was used as the matrix, the synthesized zirconium-based UiO-66 and anthocyanin-loaded ovalbumin-carboxymethylcellulose nanocomposites were embedded in to stabilize anthocyanins and improve gas adsorption performance of film.

A zeolitic imidazolate framework-90-based probe for fluorescent detection of mitochondrial hypochlorite in living cells and zebrafish.

An inorganic-organic hybrid probe MP-ZIF-90 was synthesized a simple condensation reaction based on the free CHO groups of zeolitic imidazolate framework-90 (ZIF-90) and 4-methyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)pyridinium bromide (MP). This probe exhibited intense green emission, which was selectively quenched by the addition of ClO anions. The response of probe MP-ZIF-90 toward ClO was rapid (within 20 s) and sensitive, with a limit of detection (LOD) of 0.

A p-toluenesulfonamide-modified benzo[h]chromene hydrazone: Fluorescent turn-on detection of hypochlorite and its application to imaging the endoplasmic reticula of living cells and zebrafishes.

Hypochlorite (ClO) is a ROS that plays a crucial role in the immune system in the body. As the largest organelle in the cell, the endoplasmic reticulum (ER) manages various life activities. Thus, a simple hydrazone-based probe was designed, which provided a fast turn-on fluorescent response toward ClO.

A dual-emission fluorescence probe for the detection of viscosity and hydrazine in environmental and biological samples.

The microenvironments of biological systems are associated with the pathology of organisms. This study, aimed to construct a hemicyanine-based probe (1), which can respond to mitochondrial viscosity and hydrazine (NH), for imaging application in living cells and zebrafish. The probe showed no fluorescence due to the intramolecular rotation in the solution; however, it exhibited a strong emission at 730 nm when the molecules were restricted to a high-viscosity environment.

A novel AIRE-based fluorescent ratiometric probe with endoplasmic reticulum-targeting ability for detection of hypochlorite and bioimaging.

Hypochlorite (ClO) plays an important role in the human immune defense system, but high concentrations of ClO in the endoplasmic reticulum (ER) damage cellular proteins, causing ER stress, cell death, and various diseases. Herein, we developed a simple hydrazone probe (1) featuring aggregation-induced ratiometric emission, which would quickly (within 20 s) and sensitively (detection limit of 15.4 μM) respond to ClO in an almost pure aqueous solution via a fluorescent ratiometric output.

Effects of enhanced hygiene measures on severe diarrhea and anastomotic leak after colorectal cancer surgery: the experience of a tertiary referral hospital in China.

Background: The 2019 novel coronavirus (COVID-19) global pandemic has greatly changed the mode of hospital admissions. This study summarized and analyzed the incidence of severe diarrhea and anastomotic leakage during different periods for colorectal cancer surgery.

Methods: From January 2017 to September 2020, 2,619 colorectal operations were performed in Peking Union Medical College Hospital.

A dual-ratiometric mitochondria-targeted fluorescent probe to detect hydrazine in soil samples and biological imaging.

Hydrazine (NH) is carcinogenic, extremely toxic, and induces serious environmental contamination and physiological dysfunction; however, it is widely used as an industrial material. Hence, the development of a simple and effective analytical method to detect NH detection in both environmental and biological sectors is warranted. In this work, an intramolecular charge transfer (ICT)-based fluorescent probe 1, namely (Z)- 1-(4-acetoxybenzyl)- 4-(1-cyano-2-(7-(diethylamino)- 2-oxo-2 H-chromen-3-yl)vinyl)pyridin-1-ium, was designed for dual-excitation (420 and 600 nm, excitation separations >160 nm), near infrared (NIR)-emissive, and ratiometric fluorescent detection of NH.

Europium (III) complex-based fluorescent probe for instantaneous, selective, and sensitive detection of phosgene.

Phosgene (carbonyl chloride, COCl) is a widely used colorless gas in organic synthesis. However, its high toxicity sets a severe potential damage of public safety. As the fluorescence method has the advantages of simple operation and real-time detection of phosgene, it is extremely important to develop a fluorescent phosgene probe for public health and safety.

A simple colorimetric and fluorometric probe for rapid detection of CN with large emission shift.

In this work, a novel probe R was synthesized via Knoevenagel reaction between 3H-benzo[f]chromium-2-formaldehyde and ethyl cyanoacetate for selective detection of CN in both colorimetric and fluorescent signal channels. The recognition of CN was through the nucleophilic reaction of CN to C = C of probe R, which destroys π-conjugation and blocks the ICT effect of the probe, resulting in colorimetric and fluorometric responses. Probe R showed great sensitivity toward CN, with large fluorescent emission (595 nm) and low detection limit (0.

Simultaneous detection of lysosomal SO and viscosity using a hemicyanine-based fluorescent probe.

The changes in sulfur dioxide and viscosity of lysosomes are significant indicators in physiological processes and the cell microenvironment. This study aimed to synthesize a hemicyanine-based probe for simultaneous detection of SO and viscosity. The probe could not only rationally detect sulfur dioxide in a semi-aqueous solution with high sensitivity (limit of detection = 0.

Multidimensional (0D-3D) nanofillers: Fascinating materials in the field of bio-based food active packaging.

Nanoscience paves the new way for the development of bio-based food packaging. Recently, research on bio-nanocomposite packaging has gained momentum, driven by consumers' pursuits of food quality and the reduction of resource waste. This is mainly attributable to its excellent biogradability, non-toxicity, consumer friendliness and its potential for functional properties that contribute to extending the shelf life of foods.

Site-specific sulfur-for-metal replacement in a silver nanocluster.

A new Ag nanocluster with a closed electronic structure and eight valence electrons is reported, which has a similar structure to that of an open-shell Ag nanocluster with three valence electrons, except that in the shell two (Ag-PPh) cations replace two S anions specifically. The fine structural modulation leads to various levels of activity for singlet oxygen photogeneration due to the distinct optical gaps of the nanoclusters.

A novel indene-chalcone-based fluorescence probe with lysosome-targeting for detection of endogenous carboxylesterases and bioimaging.

An indene-chalcone-based fluorescence probe 1 was synthesized and characterized. Under physiological conditions (containing 5% DMSO), probe 1 showed satisfactory stability with a low background signal and recognized carboxylesterases (CEs) based on the catalytic hydrolysis of ester groups, releasing a significant green fluorescence. Probe 1 presents several features including a short response time (within 20 min), low detection limit (1.

A quinoline-based probe for the ratiometric fluorescent detection of sulfite in lysosomes of living cells.

A lysosome-targeting ratiometric fluorescent probe was synthesized for detecting sulfite based on sulfite-triggered nucleophilic addition reaction. Due to the specific reaction, the fluorescence intensity ratio (I/I) of the probe in an almost aqueous solution (0.5% DMSO) changed significantly after the addition of HSO, corresponding to the change in the fluorescence color of the solution from green to blue.