Publications by authors named "Weiming Yang"

Bamboo is a fast-growing lignocellulosic plant in nature. It is an abundant and renewable resource with wide applications. The processing of bamboo results in a large amount of residue.

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Lactic acid is an important platform feedstock for synthesizing various chemicals. Lactic acid is normally converted from any sugar such as glucose, and Sn-β zeolite is an effective catalyst. In this study, β zeolite with different Si/Al ratios was prepared and characterized.

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Soft-magnetic fibers (SMFs) play a crucial role in energy conversion, transmission, and storage within electronic devices. However, conventional SMFs have poor plasticity and are therefore difficult to withstand long-term tensile, torsional, and shear deformation. A high fraction of grain boundaries could improve plastic deformability of conventional SMFs, but deteriorates the coercivity.

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Aims: To investigate the fundus characteristics and macular optical coherence tomography angiography (OCTA) metrics in patients with myelinated retinal nerve fibers (MRNF) and to identify the associations among myopic parameters, fundus metrics, and OCTA metrics.

Methods: The single-center case-control study included 15 patients with monocular MRNF and 15 patients without MRNF, matched for age, affected eyes' spherical equivalent error (SER), and axial length (AL) between May 2021 and December 2021. Fundus features, including the entire MRNF area (Area1), the denser MRNF area (Area2), and the shortest distance from the fovea to the MRNF border (D), along with ocular parameters, including SER, AL, best corrected visual acuity (BCVA), and OCTA metrics at the fovea, including choroidal (ChT) and retinal (ReT) thicknesses at the fovea, the foveal avascular zone area (FAZ), foveal avascular zone perimeter (FAZP), FAZ-circularity index (FAZ-CI), and foveal vessel density in a 300-µm wide region (FD-300), were assessed.

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  • The study focuses on the HIV-1 envelope (Env) protein, crucial for developing effective vaccines, and explores how the signal peptide (SP) affects its antigenicity (ability to trigger immune response) and immunogenicity (ability to induce an immune response).
  • Researchers compared the Env proteins from two different HIV-1 isolates, assessing their natural forms and chimeras with swapped SPs, using various methods to evaluate their antigenicity and responses in mice.
  • Results showed that swapping SPs influenced the antibodies' binding, with some chimeras showing improved immunogenicity, while the inclusion of DNA vaccines reduced the effectiveness of the wild-type proteins in generating a strong immune response.
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  • Hip arthroscopy is increasingly common for treating hip joint diseases, but there is debate on whether to close the joint capsule after the procedure, and the effects of this closure remain unclear.
  • This study aims to assess the outcomes of a modified shoelace suture technique for hip capsule closure and its safety compared to non-closure in patients who underwent hip arthroscopy.
  • After reviewing 100 patients, findings revealed that while surgical time was longer in the capsular closure group, there were no significant differences in hospital stay or patient-reported outcomes between the closure and non-closure groups after 12-15 months of follow-up.
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The UDP-N-acetylgalactosamine polypeptide:N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes initiates O-linked glycosylation by catalyzing the addition of the first GalNAc sugar to serine or threonine on proteins destined to be membrane-bound or secreted. Defects in individual isoforms of the GalNAc-T family can lead to certain congenital disorders of glycosylation (CDG). The polypeptide N-acetylgalactosaminyltransferase 3 (GALNT)3-CDG, is caused by mutations in GALNT3, resulting in hyperphosphatemic familial tumoral calcinosis due to impaired glycosylation of the phosphate-regulating hormone fibroblast growth factor 23 (FGF23) within osteocytes of the bone.

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The fermentation process has a significant impact on the aromatic profile of wines, particularly in relation to the difference in fermentation matrix caused by grape varieties. This study investigates the leaching and evolution patterns of aroma compounds in L. Marselan and Merlot during an industrial-scale vinification process, including the stages of cold soak, alcohol fermentation, malolactic fermentation, and one-year bottle storage.

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The tumor microenvironment (TME) is a highly heterogeneous ecosystem that plays critical roles in the initiation, progression, invasion, and metastasis of cancers. Extracellular vesicles (EVs), as emerging components of the host-tumor communication, are lipid-bilayer membrane structures that are secreted by most cell types into TEM and increasingly recognized as critical elements that regulate the interaction between tumor cells and their surroundings. They contain a variety of bioactive molecules, such as proteins, nucleic acids, and lipids, and participate in various pathophysiological processes while regulating intercellular communication.

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Unlabelled: HIV-1 replication is tightly regulated in host cells, and various restriction factors have important roles in inhibiting viral replication. SAMHD1, a well-known restriction factor, suppresses HIV-1 replication by hydrolyzing intracellular dNTPs, thereby limiting the synthesis of viral cDNA in quiescent cells. In this study, we revealed an additional and distinct mechanism of SAMHD1 inhibition during the postviral cDNA synthesis stage.

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  • The study aimed to visualize the spatial distribution of femoral head necrosis using a new measurement method called the longitude and latitude division system (LLDS).
  • Researchers analyzed CT data from 108 hips with non-traumatic osteonecrosis, creating a computer-aided design tool to visualize necrotic lesions in both 2D and 3D heat maps.
  • Results indicated that the LLDS has high reliability, revealing concentrated clustering of necrotic lesions in specific regions of the femoral head, particularly in type C lesions, which helps in understanding the differences between subtypes C1 and C2.
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  • The study highlights the challenge of lung adenocarcinoma transforming into small cell lung cancer (SCLC) as a resistance mechanism against epidermal growth factor receptor (EGFR) inhibitors like erlotinib.
  • Researchers created preclinical models to investigate this transformation and found that a mechanism involving the transcriptional regulation of EHMT2 and SFRP1 enhances resistance to erlotinib through activation of the WNT/β-catenin pathway.
  • By inhibiting EHMT2, they restored erlotinib sensitivity in transformed cell lines and slowed down resistance in animal models, suggesting a new potential treatment strategy against this form of resistance.
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Background: The impact of capsular closure vs non-closure in hip arthroscopy for femoracetabular impingement (FAI) was assessed by a meta-analysis.

Methods: With the most recent search update occurring in August 2022, relevant studies were found by searching the Pubmed and EMBASE databases. A collection of studies was made that conducted hip arthroscopy for FAI.

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Pollution from toxic spores has caused us a lot of problems because spores are extremely resistant and can survive most disinfectants. Therefore, the detection of spore response to disinfectant is of great significance for the development of effective decontamination strategies. In this work, we investigated the effect of 0.

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Ethyl carbamate (EC), a multisite carcinogenic compound, is naturally produced from urea and ethanol in alcoholic beverages. In order to reduce the content of EC in wine, the accumulation of arginine in Saccharomyces cerevisiae was regulated by genetic modifying genes involved in arginine transport and synthesis pathways to reduce the production of urea. Knockout of genes encoding arginine permease (Can1p) and amino acid permease (Gap1p) on the cell membrane as well as argininosuccinate synthase (Arg1) respectively resulted in a maximum reduction of 66.

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Purpose: To investigate topographical maps of the three-dimensional choroidal vascularity index (3D-CVI) in children with different levels of myopia.

Methods: We enrolled 274 eyes from 143 children with various severity of myopia, including emmetropia (EM), low myopia (LM), and moderate-high myopia (MHM). The choroidal vessel volume (CVV), choroidal stroma volume (CSV), and 3D-CVI in different eccentricities (fovea, parafovea, and perifovea) and quadrants (nasal, temporal, superior, and inferior) were obtained from swept-source optical coherence tomography angiography (SS-OCTA) volume scans.

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  • Cancer is a complex disease where tumor metabolism and immune response are intertwined, but their relationship needs further exploration.
  • Researchers found a negative correlation between NAMPT, an enzyme in NAD metabolism, and PD-L1 expression in various cancer cell lines, with clinical studies showing a pattern that predicts poor patient prognosis.
  • They developed a compound, LZFPN-90, that inhibits tumor growth and enhances T cell activity by co-targeting NAMPT and PD-L1, indicating potential for improved cancer treatment through this dual approach.
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N-acetylgalactosaminyl-transferases (GalNAc-Ts) initiate mucin-type O-glycosylation, an abundant and complex posttranslational modification that regulates host-microbe interactions, tissue development, and metabolism. GalNAc-Ts contain a lectin domain consisting of three homologous repeats (α, β, and γ), where α and β can potentially interact with O-GalNAc on substrates to enhance activity toward a nearby acceptor Thr/Ser. The ubiquitous isoenzyme GalNAc-T1 modulates heart development, immunity, and SARS-CoV-2 infectivity, but its substrates are largely unknown.

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The Technical Note aims to present an arthroscopic capsular closure technique at the end of the hip arthroscopy. The technology employs a dual-channel approach and modified shoelace suture technique to continuously suture the hip capsule. Recent studies have indicated that routine intraoperative repair of the articular capsule at the end of the hip arthroscopy is advocated.

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Drug resistance is the leading problem in non-small-cell lung cancer (NSCLC) therapy. The contribution of histone methylation in mediating malignant phenotypes of NSCLC is well known. However, the role of histone methylation in NSCLC drug-resistance mechanisms remains unclear.

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In this work, shrimp shell-derived magnetic NiFeO/N, O co-doped porous carbon nanozyme with superior oxidase (OXD)-like activity was prepared and used for colorimetric/photothermal/smartphone dual-signal triple-mode detection of antioxidants in fruits and beverages. The magnetic NiFeO/N, O co-doped porous carbon (MNPC) material was triumphantly fabricated using a combined in-situ surface chelation and pyrolysis method. The resultant MNPC composite exhibits a superior OXD-like activity, which can effectively oxidize 3,3',5,5'-tetramethylbenzidine (TMB) for yielding colorimetric/temperature dual-signal (CTDS) in absence of HO.

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It is widely accepted that prevéraison application of naphthaleneacetic acid (NAA) can delay the ripening of grapes and improve their quality. However, how NAA impacts grape aroma compound concentrations remains unclear. This study incorporated the analyses of aroma metabolome, phytohormones, and transcriptome of L.

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Following the highly successful Chinese American Society for Mass Spectrometry (CASMS) conferences in the previous 2 years, the 3rd CASMS Conference was held virtually on August 28-31, 2023, using the Gather.Town platform to bring together scientists in the MS field. The conference offered a 4-day agenda with a scientific program consisting of two plenary lectures, and 14 parallel symposia in which a total of 70 speakers presented technological innovations and their applications in proteomics and biological MS and metabo-lipidomics and pharmaceutical MS.

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