Advanced PROTAC and Quantitative Proteomics Strategy Reveals Bax Inhibitor-1 as a Critical Target of Icaritin in Burkitt Lymphoma.

Understanding the molecular targets of natural products is crucial for elucidating their mechanisms of action, mitigating toxicity, and uncovering potential therapeutic pathways. Icaritin (ICT), a bioactive flavonoid, demonstrates significant anti-tumor activity but lacks defined molecular targets. This study employs an advanced strategy integrating proteolysis targeting chimera (PROTAC) technology with quantitative proteomics to identify ICT's key targets.

Gas-Phase-Induced Engineering for Fabrication of 3D Hierarchical Porous Nickel and Its Application toward High-Performance Supercapacitors.

Commercial nickel foam (NF), which is composed of numerous interconnected ligaments and hundred-micron pores, is widely acknowledged as a current collector/electrode material for catalysis, sensing, and energy storage applications. However, the commonly used NF often does not work satisfactorily due to its smooth surface and hollow structure of the ligaments. Herein, a gas-phase-induced engineering, two-step gaseous oxidation-reduction (GOR) is presented to directly transform the thin-walled hollow ligament of NF into a three-dimensional (3D) nanoporous prism structure, resulting in the fabrication of a unique hierarchical porous nickel foam (HPNF).

Ultralow Strain-Induced Emergent Polarization Structures in a Flexible Freestanding BaTiO Membrane.

The engineering of ferroic orders, which involves the evolution of atomic structure and local ferroic configuration in the development of next-generation electronic devices. Until now, diverse polarization structures and topological domains are obtained in ferroelectric thin films or heterostructures, and the polarization switching and subsequent domain nucleation are found to be more conducive to building energy-efficient and multifunctional polarization structures. In this work, a continuous and periodic strain in a flexible freestanding BaTiO membrane to achieve a zigzag morphology is introduced.

Resurrected and Tunable Conductivity and Ferromagnetism in the Secondary Growth LaCaMnO on Transferred SrTiO Membranes.

To avoid the epitaxy dilemma in various thin films, such as complex oxide, silicon, organic, metal/alloy, etc., their stacking at an atomic level and secondary growth are highly desired to maximize the functionality of a promising electronic device. The ceramic nature of complex oxides and the demand for accurate and long-range-ordered stoichiometry face severe challenges.

Giant Electroresistance in Ferroelectric Tunnel Junctions via High-Throughput Designs: Toward High-Performance Neuromorphic Computing.

Ferroelectric tunnel junctions (FTJs) have been regarded as one of the most promising candidates for next-generation devices for data storage and neuromorphic computing owing to their advantages such as fast operation speed, low energy consumption, convenient 3D stack ability, etc. Here, dramatically different from the conventional engineering approaches, we have developed a tunnel barrier decoration strategy to improve the ON/OFF ratio, where the ultrathin SrTiO (STO) dielectric layers are periodically mounted onto the BaTiO (BTO) ferroelectric tunnel layer using the high-throughput technique. The inserted STO enhances the local tetragonality of the BTO, resulting in a strengthened ferroelectricity in the tunnel layer, which greatly improves the OFF state and reduces the ON state.

Enhanced oxygen evolution reaction the tunability of spin polarization and electronic states in a flexible van der Waals membranous catalyst.

The response of the magnetic field and strain engineering in an electrochemical process, such as the oxygen evolution reaction (OER), not only provides a strategy for enhancing catalytic performance through external fields and mechanical stress but also serves as a platform for revealing the functionality of multiple degrees of freedom in catalysts. The perovskite transition metal oxide (TMO) thin film with precise stoichiometry and lattice ordering enables atomic-level catalysis mechanisms in various electrochemical processes, thereby facilitating the design and engineering of promising catalysts. However, the perplexing dominance of spin in an OER process is still a puzzle due to the strong correlation between transition metal d and oxygen p orbitals.

Multi-Label Classification With Dual Tail-Node Augmentation for Drug Repositioning.

Due to the lengthy and costly process of new drug discovery, increasing attention has been paid to drug repositioning, i.e., identifying new drug-disease associations.

Magnetic Field-Enhanced Oxygen Evolution Reaction via the Tuneability of Spin Polarization in a Half-Metal Catalyst.

The magnetic field response of an electrochemistry process, such as the oxygen evolution reaction (OER), provides not only a strategy for enhanced catalytic activity by applying an external field but also a platform for revealing the functionality of the multiple degrees of freedom of the catalyst. However, the mechanism of the magnetic field tuneable OER is controversial. The strong correlation between the d and p orbitals of transition metal and oxygen still puzzles the dominant role of spin in an OER process.

A New Insight into the Singlet Oxygen Mechanism for Photodynamic Therapy.

Modern photodynamic therapy has been built on the mechanism of the interaction between the photosensitizer (porphyrin derivatives) and oxygen to produce singlet oxygen, which relies on energy transfer from the triplet excited state (T) of porphyrin to the excited state of oxygen. In this process, the energy transfer from the singlet excited state (S) of porphyrin to oxygen is believed to be not pronounced as the rapid decay of S and the large energy mismatch. Here, we have evidenced the existence of an energy transfer between S and oxygen, which can contribute to the production of singlet oxygen.

Maternal pre-pregnancy BMI, MTHFR polymorphisms, and the risk of adverse pregnancy outcomes in pregnant women from South China: a retrospective cohort study.

Background: Increasing evidence suggests an association between maternal pre-pregnancy body mass index (pre-BMI) and adverse pregnancy outcomes. However, the effects of methylenetetrahydrofolate reductase (MTHFR) polymorphisms on these relationships require further investigation. This study aimed to investigate whether the relationship between pre-BMI and the risk of adverse pregnancy outcomes was influenced by MTHFR gene polymorphisms.

The modulated oxygen evolution reaction performance of LaFeO with abundant electronic structures a design of stoichiometry offset.

Transition metal oxides have been widely employed as electrocatalysts in various electrochemical processes such as oxygen evolution reaction (OER) owing to their designable adsorption/desorption ability of water intermediates by engineering their electronic structures. However, the coexistence of multiple chemical valences of the transition metal always hides the realization of the functional active phase in OER. In this study, we have performed the OER measurements on LaFeO (LFO) catalysts to reveal the complex relationships between 3d electronic structure and its OER responses; herein, several electronic statuses, including t42ge2g ( = 2), t52ge1g ( = 1), or t62ge0g ( = 0) of Fe ions, can be dominantly achieved by the design of stoichiometry offset in LFO.

Extreme Enhanced Curie Temperature and Perpendicular Exchange Bias in Freestanding Ferromagnetic Superlattices.

Most recently, the freestanding of an epitaxial single-crystal oxide has been greatly developed to its fundamental concerns and the possibility of integration with metal, two-dimensional, and organic materials for more promising functionalities. In an artificial ferromagnetic oxide heterostructure and superlattice, the release of the substrate constraint can induce a reasonable transformation of the magnetic structure because the change of the lattice field occurs. In this study, we have comprehensively investigated the evolution of magnetic properties of (LaCaMnO/SrRuO) [(LCMO/SRO)] ferromagnetic superlattices while they are epitaxially on SrTiO and freestanding.

Enhanced OER Performance and Dynamic Transition of Surface Reconstruction in LaNiO Thin Films with Nanoparticles Decoration.

In an electrocatalytic process, the cognition of the active phase in a catalyst has been regarded as one of the most vital issues, which not only boosts the fundamental understanding of the reaction procedure but also guides the engineering and design for further promising catalysts. Here, based on the oxygen evolution reaction (OER), the stepwise evolution of the dominant active phase is demonstrated in the LaNiO (LNO) catalyst once the single-crystal thin film is decorated by LNO nanoparticles. It is found that the OER performance can be dramatically improved by this decoration, and the catalytic current density at 1.

Domain Switching in BaTiO Films Induced by an Ultralow Mechanical Force.

Low-energy switching of ferroelectrics has been intensively studied for energy-efficient nanoelectronics. Mechanical force is considered as a low-energy consumption technique for switching the polarization of ferroelectric films due to the flexoelectric effect. Reduced threshold force is always desirable for the considerations of energy saving, easy domain manipulation, and sample surface protection.

Polymorphisms in gene modify the association between gestational weight gain and adverse birth outcomes.

Evidence suggests a potential relationship between gestational weight gain (GWG) and adverse birth outcomes. However, the role of maternal genetic polymorphisms remains unclear. This study was conducted to investigate whether the relationship of GWG with risk of adverse birth outcomes was modified by methylenetetrahydrofolate reductase () polymorphisms.

Strain Modified Oxygen Evolution Reaction Performance in Epitaxial, Freestanding, and Van Der Waals Manganite Thin Films.

In perovskite complex oxides, the strain has been established as a promising approach for tuning the oxygen evolution reaction (OER) performance by the manipulated electronic structure and interaction/coupling. In this study, we have employed rigid epitaxial, flexible freestanding, and van der Waals LaSrMnO (LSMO) to investigate the strain effects on OER, which are different in stress strength and range via lattice mismatch and curvature change. It was found that the OER performances as a function of strain exhibited volcano and monotonous trends in rigid and flexible LSMO, respectively.

Simultaneously achieving giant piezoelectricity and record coercive field enhancement in relaxor-based ferroelectric crystals.

A large coercive field (E) and ultrahigh piezoelectricity are essential for ferroelectrics used in high-drive electromechanical applications. The discovery of relaxor-PbTiO crystals is a recent breakthrough; they currently afford the highest piezoelectricity, but usually with a low E. Such performance deterioration occurs because high piezoelectricity is interlinked with an easy polarization rotation, subsequently favoring a dipole switch under small fields.

Effect of Patient-Controlled Epidural Analgesia (PCEA) Based on ERAS on Postoperative Recovery of Patients Undergoing Gynecological Laparoscopic Surgery.

Objective: To explore the effect of patient-controlled epidural analgesia (PCEA) based on enhanced recovery after surgery (ERAS) on the postoperative recovery of patients undergoing gynecological laparoscopic surgery.

Methods: Between January 2019 and December 2020, 90 patients scheduled for gynecological laparoscopic surgery and assessed for eligibility were recruited and randomly assigned at a ratio of 1 : 1 to receive either conventional analgesic management (regular group) or PCEA based on ERAS (ERAS group). Comparisons of postoperative rehabilitation indicators, visual analogue scale (VAS) score, self-care ability, complications, and nursing satisfaction were conducted between the two groups.

Surface Atomic Decoration of a Manganite to a Modulable Oxygen Evolution Reaction.

Aiming at the fundamental understanding of oxygen evolution reaction (OER) in epitaxial perovskite transition metal oxide (TMO) thin films, we evaluate the surface decoration conditions, including lattice orientation and surface morphology, of LaSrMnO (LSMO) related to its modulable OER performance. The LSMOs with orientations of (001), (110), and, (111) exhibit different OER activities owing to the discrepant surface density of Mn. Furthermore, tuning of the surface atomic terrace width of LSMO shows a more efficient path to modulate the OER performance by introducing a high-valence Mn state owing to the surface dangling bonds of LSMO.

Effects of Cognitive Nursing Combined with Continuous Nursing on Postpartum Mental State and Rehabilitation.

Purpose: This study is aimed at exploring the effects of cognitive nursing combined with continuous nursing on postpartum mental state and rehabilitation.

Methods: Totally, 124 puerperas admitted to our hospital from January 2019 to January 2020 were selected and divided into a research group and a control group according to different nursing methods, with 62 cases in each group. The control group received routine care, while the research group received cognitive nursing combined with continuous nursing on this basis.

[Determination of quinoxalines veterinary drug residues in food products of animal origin by high performance liquid chromatography-tandem mass spectrometry].

Objective: To establish a high performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS)method for simultaneous determination of olaquindox, quinoxaline-2-carboxylic acid, 3-methyl-quinoxaline-2-carboxylic acid in food products of animal origin.

Methods: Samples were extracted with ethyl acetate-0.1 mol/L sodium dihydrogen phosphate(1∶9, V/V) solution in water bath at 40 ℃, purified by solid phase extraction column(olaquindox uses HLB SPE cartridge, quinoxaline-2-carboxylic acid and 3-methyl-quinoxaline-2-carboxylic acid use MAX SPE cartridge), evaporated by concentrator, and dissolved by mobile phase.

Amorphous nonstoichiometric oxides with tunable room-temperature ferromagnetism and electrical transport.

Material functionalities strongly depend on the stoichiometry, crystal structure, and homogeneity. Here we demonstrate an approach of amorphous nonstoichiometric inhomogeneous oxides to realize tunable ferromagnetism and electrical transport at room temperature. In order to verify the origin of the ferromagnetism, we employed a series of structural, chemical, and electronic state characterizations.