INGC-GAN: An Implicit Neural-Guided Cycle Generative Approach for Perceptual-Friendly Underwater Image Enhancement.

The key requirement for underwater image enhancement (UIE) is to overcome the unpredictable color degradation caused by the underwater environment and light attenuation, while addressing issues, such as color distortion, reduced contrast, and blurring. However, most existing unsupervised methods fail to effectively solve these problems, resulting in a visual disparity in metric-optimal qualitative results compared with undegraded images. In this work, we propose an implicit neural-guided cyclic generative model for UIE tasks, and the bidirectional mapping structure solves the aforementioned ill-posed problem from the perspective of bridging the gap between the metric-favorable and the perceptual-friendly versions.

Prediction of post‑nephroureterectomy renal function in non‑dialysis upper tract urothelial carcinoma using machine learning with PyCaret and SHAP explanations.

Renal function after radical nephroureterectomy (RNU) in patients with advanced upper tract urothelial carcinoma (UTUC) is an indicator of eligibility for postoperative chemotherapy. The present study aimed to utilize machine learning for predicting renal function status after RNU and to investigate the contribution of several features to this prediction. The present retrospective study included 764 medical records of patients with non-metastatic UTUC who received RNU from 2008 to 2022.

Hippocampal Volume Reductions in Key Regions and Their Role in Disease Progression in Adolescents at High Risk for Bipolar Disorder: Findings From the sBEAD Cohort.

Background: Hippocampal subfield pathology is established in bipolar disorder (BD); yet no studies have investigated these alterations in adolescents at clinical high risk for BD (MDD-Sub), which is a critical gap given adolescence as a neurodevelopmental window for early intervention.

Methods: We analyzed baseline 3D T1-weighted MRI data from 72 adolescents at Clinical High Risk for BD "MDD-Sub"MDD-Sub vs. MDD-nSub, 74 pure adolescents with MDD (MDD-nSub), and 72 healthy adolescents (HC) aged 12-18 years in the sBEAD cohort.

Straw mineralization and carbon dioxide emissions in soils with different salinity levels.

Straw application is widely used to reclaim saline soils. However, the characteristics of straw mineralization and its induced priming effects (PE) in saline soil are largely unknown. Thus, we conducted a 180-day saline soil incubation experiment to observe the characteristics of straw mineralization and CO emissions.

Risk-stratified treatment of sonrotoclax with chemotherapy in newly diagnosed acute myeloid leukemia: a study protocol.

Acute myeloid leukemia (AML) treatment relied on anthracyclines and cytarabine based intensive chemotherapy. However, clinical outcomes are unsatisfied for patients with intermediate/adverse cytogenetics based on European Leukemia Net (ELN) risk stratification 2022 (ELN 2022), and relapses also remain common even in patients with favorable-risk cytogenetics with measurable residual disease (MRD). There is an urgent unmet need for optimizing intensive chemotherapy regimens with novel agents, to enhance the MRD-negative rate, achieve durable remission, and improve the prognosis of AML.

Risk Factors Predictive of Contralateral Recurrence of Upper Tract Urothelial Carcinoma Include Chronic Kidney Diseases and Postoperative Initiation of Dialysis.

Background: The objective of the present study was to evaluate the impact of dialysis on patients with upper tract urothelial carcinoma (UTUC) who are undergoing surgical intervention, as well as to identify predictive factors linked to contralateral recurrence.

Methods: A retrospective review was conducted on patients who underwent radical nephroureterectomy (RNU) for non-metastatic UTUC at our institution from 2000 to 2013. The contralateral recurrence rate was calculated using the Kaplan-Meier method, and multivariate logistic regression analysis was employed to examine the relationship between clinicopathological characteristics and contralateral recurrence.

[Occurrence Characteristics and Influencing Factors of Microplastics in Surface Water, Sediments, and Benthic Macroinvertebrates in Huangbai River].

Microplastics are emerging as a novel environmental contaminant and pose a substantial threat to riverine ecosystems. This research focused on the Huangbai River, employing field sampling, laboratory experiments, and statistical analyses during April and July 2023. The objective of this study was to clarify the magnitude of microplastic contamination in surface water, sediment, and the benthic macroinvertebrate community.

Impact of dialysis on intravesical recurrence and survival outcomes in upper tract urothelial cancer patients undergoing radical nephroureterectomy.

Background: Upper tract urothelial carcinoma (UTUC) presents a significant recurrence risk following radical nephroureterectomy (RNU). Patients on dialysis may experience unique clinical trajectories due to uremic states and altered immune responses.

Objective: To evaluate the impact of dialysis on intravesical recurrence and survival outcomes in patients with UTUC undergoing RNU, and to identify predictive factors influencing prognosis.

Effect of Genicular Nerve Block (GNB) on Pain in Lesions of the Knee Joint: A Meta-Analysis of Randomized Controlled Trials.

To explore the effect of genicular nerve block (GNB) on pain in lesions of the knee joint. Computerized searches of randomized controlled trials were conducted in PubMed, EMbase, Cochrane Library, and Web of Science, with a search time frame until January 2024. Methodological and experimental quality was assessed using the risk of bias assessment tool recommended by the Cochrane Handbook.

Adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia undergoing allogeneic hematopoietic stem cell transplantation and tyrosine kinase inhibitors: development and validation of a clinical prediction model based on cytogenetics, IKZF1 deletions and minimal residual disease.

The aim of this study was to develop and validate a nomogram predicting progression-free survival (PFS) for adult patients with positive acute lymphoblastic leukemia(Ph + ALL) who have undergone allogeneic hematopoietic stem cell transplantation(allo-HSCT) and tyrosine kinase inhibitor(TKI) treatment. Data were retrospectively collected from 176 adult patients diagnosed with Ph + ALL and treated with allo-HSCT and TKIs at The First Affiliated Hospital, Zhejiang University School of Medicine, between January 2015 and May 2023. 70% of the patients were randomly assigned to the training group(n = 124) and 30% of the patients were assigned to the validation group(n = 52).

Comprehensive bioinformatics analysis reveals novel potential biomarkers associated with aging and mitochondria in osteoporosis.

Osteoporosis (OP) is a prevalent age-related bone metabolic disease. Aging and mitochondrial dysfunction are involved in the onset and progression of OP, but the specific mechanisms have not been elucidated. The aim of this study was to identify novel potential biomarkers associated with aging and mitochondria in OP.

Repurposing of Metformin to Improve Survival Outcomes in Patients With Upper Tract Urothelial Carcinoma.

Purpose: Upper tract urothelial carcinoma (UTUC) presents a higher incidence rate in Taiwan compared to Western societies. The aim of this study is to investigate the potential of metformin in improving survival outcomes for patients with UTUC in Taiwan.

Material And Methods: This retrospective study included 940 patients with UTUC and type 2 diabetes from the Taiwan UTUC Collaboration Group, spanning 21 hospitals from July 1988 to September 2023.

Secular trends in motor abilities of Xinjiang children and adolescents aged 7-18 years from 1985 to 2019.

Objective: To assessment the secular trend in physical fitness of children and adolescents aged 7-18 years in Xinjiang from 1985 to 2019.

Method: The data are derived from test scores of Xinjiang Chinese children and adolescents aged 7-18 years by the China National Student Health Monitoring Centre National Student Physical Fitness Monitoring in 1985, 1991, 1995, 2000, 2005, 2010, 2014, and 2019. The physical fitness indicators included speed, cardiorespiratory fitness, muscular strength, power, and flexibility.

Effects of pre-experimental fasting and sheltering on the swimming performance and oxygen consumption of juvenile grass carp (Ctenopharyngodon idella).

This study investigated the effects of pre-experimental fasting for 2, 7, and 14 days under both unsheltered (12 h dark-12 h light) and sheltered conditions on the critical swimming speed (U) and oxygen consumption (MO) of juvenile grass carp, using a modified swim respirometer. Key findings include (1) the U of test fish decreased significantly, by 28%, after fasting for 14 days and sheltering intensified the impact to a 43% decrease, and (2) fish anaerobic capacity decreased after 7 days but increased after 14 days, and was enhanced by sheltering conditions. These findings are important as they indicate that fasting and sheltering can impair grass carp survival and disrupt river ecosystem balance, highlighting the need for habitat conservation.

Patient-reported outcomes in adults with tyrosine kinase inhibitor-resistant chronic myeloid leukemia receiving olverembatinib therapy.

Background: The objective of this study was to assess patient-reported outcomes (PROs), including health-related quality of life (HRQoL) and anxiety and depression symptoms, and to identify associated variables in patients with tyrosine kinase inhibitor (TKI)-resistant chronic myeloid leukemia (CML) in chronic-phase (CP) or accelerated-phase (AP) who were receiving olverembatinib.

Methods: Patients in multicenter studies were invited to complete the European Organization for Research and Treatment of Cancer Quality-of-Life Core 30 Questionnaire, the Self-Rating Anxiety Scale, and the Self-Rating Depression Scale at baseline and regularly during olverembatinib therapy. The time trends in PROs were estimated with a linear model using a generalized estimating equation based on an independent working correlation matrix.

A Method for Detecting Depression in Adolescence Based on an Affective Brain-Computer Interface and Resting-State Electroencephalogram Signals.

Depression is increasingly prevalent among adolescents and can profoundly impact their lives. However, the early detection of depression is often hindered by the time-consuming diagnostic process and the absence of objective biomarkers. In this study, we propose a novel approach for depression detection based on an affective brain-computer interface (aBCI) and the resting-state electroencephalogram (EEG).

Association of health behaviors in life's essential 8 and hypertension in adolescents: a cross-sectional study from the NHANES database.

Background: Hypertension is a common condition during adolescence with increasing prevalence globally, alongside the epidemic of unhealthy lifestyles and obesity. Health behaviors have been shown to be associated with hypertension risk in adults. Life's essential 8 (LE8), as a comprehensive indicator to evaluate cardiovascular health (CVH), includes 4 health factors and 4 health behaviors.

A Novel Scale System Based on the Frailty Index and Laboratory Indicators for the Short-Term Prognosis of Patients with Acute Myocardial Infarction: A Retrospective Cohort Study.

Objective: Current scoring systems for short-term prognosis in patients with acute myocardial infarction (AMI) lack coverage of risk factors and have limitations in risk stratification. The aim of this study was to develop a novel assessment system based on laboratory indicators and frailty quantification to better infer short-term prognosis and risk indication in patients with AMI.

Methods: A total of 365 patients with MI from January 2022 to June 2023 in Northern Jiangsu Province Hospital were included.

Effect of preoperative oral nutritional supplements on clinical outcomes in patients undergoing surgery for gastrointestinal cancer: A systematic review and meta-analysis.

Background: The clinical benefit of preoperative oral nutritional supplements (ONS) in patients undergoing surgery for gastrointestinal cancer remains controversial.

Objective: To evaluate the effect of preoperative ONS on postoperative clinical outcomes in patients with gastrointestinal cancer.

Methods: We searched PubMed, EMBASE, Web of Science, Cochrane Library, Scopus, and the Chinese National Knowledge Infrastructure databases for randomized controlled trials evaluating preoperative ONS in patients undergoing surgery for gastrointestinal cancer from inception until April 2024.