Publications by authors named "Weimin Yao"

Purpose: Obstructive sleep apnea (OSA) is common in patients with hypertension. Our study aims to construct and validate an objective nomogram that can accurately predict the risk of OSA in patients with hypertension.

Patients And Methods: Retrospective data were collected from patients with hypertension who underwent polysomnography (PSG) at the Sleep Medicine Center of the First Affiliated Hospital of Guangzhou Medical University, China.

View Article and Find Full Text PDF

Obstructive sleep apnea (OSA) often leads to complications in the elderly. This study compares the usefulness of five screening tools for OSA in elderly patients. Data from elderly patients diagnosed with OSA, collected from the Sleep Medicine Center of the First Affiliated Hospital of Guangzhou Medical University from January 2012 to June 2017, is analyzed.

View Article and Find Full Text PDF

Background: To identify the risk factors for bronchiectasis patients with active pulmonary tuberculosis (APTB) and to develop a predictive nomogram model for estimating the risk of APTB in bronchiectasis patients.

Methods: A retrospective cohort study was conducted on 16,750 bronchiectasis patients hospitalized at the Affiliated Hospital of Guangdong Medical University and the Second Affiliated Hospital of Guangdong Medical University between January 2019 and December 2023. The 390 patients with APTB were classified as the case group, while 818 patients were randomly sampled by computer at a 1:20 ratio from the 16,360 patients with other infections to serve as the control group.

View Article and Find Full Text PDF
Article Synopsis
  • * An analysis of 14 studies with nearly 27,400 participants found that plant-based, low-fat, and certain alternative diets significantly reduced ED risk, while high-protein low-fat diets and high-carb low-fat diets improved erectile function scores.
  • * The findings suggest that diets rich in fruits, vegetables, and nuts, along with combined diet and exercise interventions, may enhance erectile function and offer promising management strategies for ED.
View Article and Find Full Text PDF

Evidence for the treatment of patients with mild-to-moderate chronic obstructive pulmonary disease (COPD) is limited. The efficacy of N-acetylcysteine (an antioxidant and mucolytic agent) for patients with mild-to-moderate COPD is uncertain. In this multicentre, randomised, double-blind, placebo-controlled trial, we randomly assigned 968 patients with mild-to-moderate COPD to treatment with N-acetylcysteine (600 mg, twice daily) or matched placebo for two years.

View Article and Find Full Text PDF

The mitochondrion serves as a critical intracellular organelle, engaging in essential roles in the regulation of energy production, oxidative stress management, calcium homeostasis, and apoptosis. One such disease that has been particularly associated with these functions is kidney stone disease (KSD), specifically calcium oxalate (CaOx). It is underpinned by oxidative stress and tissue inflammation.

View Article and Find Full Text PDF

Introduction: Chronic obstructive pulmonary disease (COPD), an incurable chronic respiratory disease, has become a major public health problem. The relationship between the composition of intestinal microbiota and the important clinical factors affecting COPD remains unclear. This study aimed to identify specific intestinal microbiota with high clinical diagnostic value for COPD.

View Article and Find Full Text PDF

Secondary osteoporosis is frequently due to the use of high-dose glucocorticoids (GCs). The existing strategy for managing glucocorticoid-induced osteoporosis (GIOP) is considered insufficient and remains in a state of ongoing evolution. Therefore, it is crucial to develop more precise and effective agents for the treatment of GIOP.

View Article and Find Full Text PDF

Cellular senescence is an important factor leading to pulmonary fibrosis. Deficiency of 8-oxoguanine DNA glycosylase (OGG1) in mice leads to alleviation of bleomycin (BLM)-induced mouse pulmonary fibrosis, and inhibition of the OGG1 enzyme reduces the epithelial mesenchymal transition (EMT) in lung cells. In the present study, we find decreased expression of OGG1 in aged mice and BLM-induced cell senescence.

View Article and Find Full Text PDF
Article Synopsis
  • 8-oxoguanine (8-oxoG) is a DNA lesion caused by reactive oxygen species that leads to genetic instability, and it's recognized by the repair protein OGG1.
  • OGG1 plays a dual role in base excision repair and regulates gene expression, particularly during the activation of fibroblasts in lung fibrosis.
  • Increasing OGG1 levels during fibroblast activation enhances pro-fibrotic gene expression in response to bleomycin, suggesting that targeting OGG1 could be a viable therapeutic strategy for treating Idiopathic Pulmonary Fibrosis (IPF).
View Article and Find Full Text PDF

Microplastics (MPs) have been recognized as prominent anthropogenic pollutants that inflict significant harm to marine ecosystems. Various approaches have been proposed to mitigate the risks posed by MPs. Gaining an understanding of the morphology of plastic particles can provide valuable insights into the source and their interaction with marine organisms, which can assist the development of response measures.

View Article and Find Full Text PDF

Background: Ginsenosides, phenolic compounds, and polysaccharides are the bioactive constituents of Panax ginseng Meyer. Compound K (CK) is a secondary ginsenoside with better bioavailability. It is also a promising anticancer agent.

View Article and Find Full Text PDF

Background: Glanders is a rare zoonotic disease caused by Burkholderia mallei. Humans can be infected by B. mallei, which causes cutaneous lymphadenitis and pneumonia, leading to sepsis and death in severe cases.

View Article and Find Full Text PDF

Sepsis-induced fulminant hepatitis (FH) is a fatal syndrome that has a worse prognosis in clinical practice. Hence, seeking effective agents for sepsis-induced FH treatment is urgently needed. Fibroblast growth factors (FGFs) are vital for tissue homeostasis and damage repair in various organs including the liver.

View Article and Find Full Text PDF

Background: We have reported that heparin-binding epidermal growth factor (HB-EGF) is increased in patients with chronic obstructive pulmonary disease (COPD) and associated with collagen deposition, but the mechanisms remain unclear. In the present study, we aimed to investigated the inflammatory cytokines secreted by bronchial epithelial cells following exposure to HB-EGF that promoted proliferation and migration of human lung fibroblast.

Methods: HB-EGF-induced inflammatory cytokines were assayed in two airway epithelial cells (primary human bronchial epithelial cells [HBECs] and BEAS-2B cells).

View Article and Find Full Text PDF

In this study, we determined the spatial variations and potential risks of heavy metals in the sediments of Yueqing Bay by assessing the relationship between metal concentrations and sediment physiochemical factors. We found higher sediment metal concentrations in the inner bay than in the central and outer bay, particularly with respect to Hg, Cu, and Pb concentrations. According to the sediment quality guidelines, the heavy metals had a toxicity incidence probability of 21%.

View Article and Find Full Text PDF

To assess the preoperative risk factors for postoperative urosepsis after mini-percutaneous nephrolithotomy (mPCNL) in patients with large kidney stones. Records of 171 patients with large (≥30 mm) kidney stones who underwent mPCNL from December 2013 to October 2019 were reviewed. Demographic data of patients, preoperative urine analysis, urine culture, and routine blood tests and abdominal computerized cosmography data were collected and analyzed.

View Article and Find Full Text PDF

CD46 is well known to be involved in diverse biological processes. Although several splice variants of CD46 have been identified, little is known about the contribution of alternative splicing to its tumorigenic functions. In this study, we found that exclusion of CD46 exon 13 is significantly increased in bladder cancer (BCa) samples.

View Article and Find Full Text PDF

Background: Increased hypoxia-inducible factor 2α (HIF2α) activation is a common event in clear cell renal cell carcinoma (ccRCC) progression. However, the function and underlying mechanism of HIF2α in ccRCC remains uninvestigated. We conducted this study to access the potential link between junction plakoglobin (JUP) and HIF2α in ccRCC.

View Article and Find Full Text PDF

The DNA repair enzyme 8-oxoguanine DNA glycosylase-1 (OGG1) is involved in early embryonic development, as well as in multiple conditions, including cardiac fibrosis, diabetes, and neurodegenerative diseases. But, function of OGG1 in pulmonary fibrosis was not entirely clear. In this study, we identified a novel function of OGG1 in the cell transformation process in pulmonary fibrosis.

View Article and Find Full Text PDF

Background: Aberrant alternative splicing events play critical roles in carcinogenesis and progression of many cancers, while sparse studies regarding to alternative splicing are available for clear cell renal cell carcinoma (ccRCC). We identified that alternative splicing of coiled-coil domain containing 50 (CCDC50) was dysregulated in ccRCC, whereas the clinical significance of this splicing event and its splicing regulation mechanisms were still elusive.

Methods: Bioinformatic algorithm was utilized to identify significant exon skipping events in ccRCC via exon sequencing data from The Cancer Genome Atlas.

View Article and Find Full Text PDF

Background And Aims: Aging-induced bone loss is a multifactorial, age-related, and progressive phenomenon among the general population and may further progress to osteoporosis and increase the risk of fractures. Cycloastragenol (CAG), currently the only compound reported that activates human telomerase, is thought to be able to alleviate or delay the symptoms of aging and chronic diseases. Previous research has suggested that CAG may have the potential to alleviate age-related bone loss.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionebpd0ia0cchglhvhnkedcq15t6ce4cj7): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once