Publications by authors named "Weimin Wan"

As a complicated and heterogeneous condition, breast cancer (BC) has posed a tremendous public health challenge across the world. Recent studies have uncovered the crucial effect of human microbiota on various perspectives of health and disease, which include cancer. The oral-gut microbiome axis, particularly, have been implicated in the occurrence and development of colorectal cancer through their intricate interactions with host immune system and modulation of systemic inflammation.

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Ethnopharmacological Relevance: Cholestatic liver disease (CLD) is a disease characterized by cholestasis. Farnesoid X receptor (FXR) is a nuclear receptor that maintains homeostasis in bile acid metabolism. Studies have shown that gut microbiota interfered with the FXR pathway.

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Article Synopsis
  • Cellulose nanocrystals (CNCs) are biodegradable and compatible materials that can be modified to improve drug delivery systems, making them effective carriers for medications.
  • The researchers grafted glycidyl onto CNCs to create hyperbranched polymers, which enhanced cell uptake, and then developed a pH-responsive nano-delivery system using specific monomers (VB and PEGMA) through a unique polymerization method.
  • This new system, CNCs-VB-PEGMA, was capable of loading curcumin at a high rate and showed promising results in targeting and killing liver cancer cells in both 2D and 3D models.
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  • Alcoholic liver disease (ALD) poses a significant global health risk, with limited effective treatments available, prompting research into the protective effects of Qiwei Jinggan Ling (QJL) on ALD.
  • The study involved testing QJL's effects on ALD in both live mice and liver cells, measuring various indicators of liver health and investigating the underlying mechanisms through advanced techniques like RNA sequencing.
  • Results showed that QJL improved liver structure, reduced oxidative stress, and positively influenced alcohol and fat metabolism by affecting key proteins and genes involved in these processes.
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Ethnopharmacological Relevance: Polygala fallax Hemsl. is a traditional folk medicine commonly used by ethnic minorities in the Guangxi Zhuang Autonomous Region, and has a traditional application in the treatment of liver disease. Polygala fallax Hemsl.

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Microvesicles known as exosomes have a diameter of 40 to 160 nm and are derived from small endosomal membranes. Exosomes have attracted increasing attention over the past ten years in part because they are functional vehicles that can deliver a variety of lipids, proteins, and nucleic acids to the target cells they encounter. Because of this function, exosomes may be used for the diagnosis, prognosis and treatment of many diseases.

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Macrophages, as highly phenotypic plastic immune cells, play diverse roles in different pathological conditions. Changing and controlling the phenotypes of macrophages is considered a novel potential therapeutic intervention. Meanwhile, specific transmembrane proteins anchoring on the surface of the macrophage membrane are relatively conserved, supporting its functional properties, such as inflammatory chemotaxis and tumor targeting.

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Article Synopsis
  • Carbapenem-resistant (CR) complex poses a significant public health threat with high mortality rates, particularly in patients infected with this newly identified group of bacteria.
  • A study examined 25 CR complex isolates from multiple regions in China, finding a variety of infection sources, a poor prognosis in 32% of cases, and identifying three species with the most common being one specific type.
  • The research uncovered different carbapenemase genes and a diverse array of genetic sequences, revealing a polyclonal spread of CR complex in China, which adds to the knowledge of its prevalence and antibiotic resistance.
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Idiopathic pulmonary fibrosis (IPF) is the most common form of idiopathic interstitial pneumonia, where M2 macrophages play an irreplaceable role in the anti-inflammatory progress. Targeting M2 macrophages and regulating their polarization may be a potential treatment strategy for IPF. Herein, we designed a magnetic liposome based dual-targeting delivery system for the IPF treatment, constructed by mannose-modified magnetic nanoparticles (MAN-MNPs) loaded on the surface of the liposome (MAN-MNPs@LP).

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Hydroxyapatite (HAP) materials are widely applied as biomedical materials due to their stable performance, low cost, good biocompatibility and biodegradability. Here, a green, fast and efficient strategy was designed to construct a fluorescent nanosystem for cell imaging and drug delivery based on polyethyleneimine (PEI) and functionalized HAP via simple physical adsorption. First, HAP nanorods were functionalized with riboflavin sodium phosphate (HE) to provide them with fluorescence properties based on ligand-exchange process.

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Herein, a novel strategy for surface functionalization and drug loading of cellulose nanocrystals (CNCs) through formation of hydrazone bonds between functionalized CNCs and aldehyde group containing polyethylene glycol (CHO-PEG)/anticancer drug doxorubicin (DOX) was reported for the first time. DOX could be loaded on PEGylated CNCs with high capacity and released from drug complexes (P-CNCs-D) with pH dependent behavior. The biological evaluation results demonstrated that drug carriers (CNCs-EBO-NH) showed negative cytotoxicity while DOX could be transported into cells and exhibits desirable anticancer effects.

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Nanodiamond (ND) has been widely studied as a new type of carbon nanomaterials that is expected to be used as a promising candidate in various fields especially in the field of biomedicine. However, its poor water dispersibility and insufficient controlled release limit its practical applications. In this paper, ND-based composites with pH-responsive hydrazone bonds were successfully prepared by a simple chemical reaction between ester groups and hydrazine hydrate, in which ester groups were conjugated on the surface of ND via thiol-ene click reaction.

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Synopsis of recent research by authors named "Weimin Wan"

  • Recent research by Weimin Wan focuses on the development of innovative drug delivery systems using nanomaterials such as cellulose nanocrystals and magnetic liposomes, demonstrating improved biocompatibility and targeted delivery for therapeutic applications.
  • His studies on natural extracts, like those from Desmodium styracifolium and Qiwei Jinggan Ling, reveal their potential in alleviating liver diseases through specific cellular mechanisms and pathways, particularly in cholestatic and alcoholic liver disease contexts.
  • Additionally, Wan's work includes investigating the roles of macrophages in treatment strategies and exploring the genomic characterization of carbapenem-resistant bacteria, reflecting a commitment to addressing significant health challenges through multi-faceted research approaches.