Advances in systemic treatment for recurrent metastatic cervical cancer.

Cervical cancer remains a leading cause of cancer-related mortality among women worldwide, particularly in underdeveloped nations. Despite advances in standard therapies, patients with recurrent metastatic cervical cancer face a poor prognosis and limited treatment options. This study aims to evaluate the efficacy and safety of emerging therapeutic approaches in managing this challenging condition, including immunotherapy, targeted medicines, and chemotherapy.

Anthracycline chemicals with anthracyclinone structure exert antitumor effects by inhibiting angiogenesis and lymphangiogenesis in a xenografted gastric tumor model.

Background: It is vital to screen or develop alternative therapeutic drugs with higher curative characteristics and fewer side effects for the clinical treatment of gastric cancer.

Methods: Gastric cancer cells were exposed to different auramycin G doses while determining the impact on cell viability, migration, and invasion. Then the antitumor effects of auramycin G, 5-fluorouracil (5-Fu) and their combination were evaluated.

Rational design of hierarchically nanostructured NiTe@CoxSy composites for hybrid supercapacitors with impressive rate capability and robust cycling durableness.

The hierarchically nanostructured NiTe@CoxSy composites are constructed on a foamed nickel substrate by a two-step electrode preparation process. Structural characterization shows the dense growing of CoxSy nanosheets around NiTe nanorods forms a hierarchical nanostructure which possesses synergetic effects from both compositional and structural complementarity, more pathways for ion/electrolyte transport, richer redox active sites, and better conductivity. Thanks to the rational design of this hierarchical structure, NiTe@CoxSy delivers a high areal capacitance of 7.

CQMUH-011 Inhibits LPS-Induced Microglia Activation and Ameliorates Brain Ischemic Injury in Mice.

Excessive microglial activation-mediated neuroinflammation is closely involved in the pathogenesis of several neurological diseases. CQMUH-011, as a novel adamantane sulfonamide compound, has been shown anti-inflammatory properties in activated macrophages (RAW264.7).

Bone marrow mesenchymal stem cells inhibit cardiac hypertrophy by enhancing FoxO1 transcription.

Bone marrow-derived mesenchymal stem cells (BMSCs) have therapeutic potential for certain heart diseases. Previous studies have shown that stem cells inhibit cardiac hypertrophy; however, it is necessary to explore the mechanisms underlying this effect. This study aimed to investigate the possible mechanism underlying the inhibitory effect of BMSCs on cardiomyocyte hypertrophy.

In Situ Preparation of Amphibious ZnO Quantum Dots with Blue Fluorescence Based on Hyperbranched Polymers and their Application in Bio-Imaging.

A new strategy for preparing amphibious ZnO quantum dots (QDs) with blue fluorescence within hyper-branched poly(ethylenimine)s (HPEI) was proposed in this paper. By changing [Zn]/[OH] molar ratio and heating time, ZnO QDs with a quantum yields (QY) of 30% in ethanol were obtained. Benefiting from the amphibious property of HPEI, the ZnO/HPEI nanocomposites in ethanol could be dissolved in chloroform and water, acquiring a QY of 53%, chloroform and 11% in water.

Inhibition of COX2/PGD2-Related Autophagy Is Involved in the Mechanism of Brain Injury in T2DM Rat.

The present study was designed to observe the effect of COX2/PGD2-related autophagy on brain injury in type 2 diabetes rats. The histopathology was detected by haematoxylin-eosin staining. The learning and memory functions were evaluated by Morris water maze.

Changes in the levels of 12/15-lipoxygenase, apoptosis-related proteins and inflammatory factors in the cortex of diabetic rats and the neuroprotection of baicalein.

This study was designed to investigate the neuroprotective effects of baicalein and the effect of the cortical 12/15-lipoxygenase (12/15-LOX) pathway on diabetic cognitive dysfunction. Our results showed that spatial learning and memory ability, as well as cortex neurons, were significantly impaired after the onset of diabetes. The fasting blood glucose and random blood glucose levels in the model group were significantly higher than those in the normal group.

CREB/Wnt10b mediates the effect of COX-2 on promoting BMP9-induced osteogenic differentiation via reducing adipogenic differentiation in mesenchymal stem cells.

Bone morphogenetic protein 9 (BMP9) is one of the most potent osteogenic factors, which may be a potential candidate for bone tissue engineering. However, the osteogenic capacity of BMP9 still need to be further enhanced. In this study, we determined the effect of Wnt10b on BMP9-induced osteogenic differentiation in mesenchymal stem cell (MSCs) and the possible mechanism underlying this process.

Self-template synthesis of hollow ellipsoid Ni-Mn sulfides for supercapacitors, electrocatalytic oxidation of glucose and water treatment.

In this work, we have successfully developed a simple self-template route for preparation of hollow ellipsoid Ni-Mn sulfides. This route involves the synthesis of solid Ni-Mn ellipsoids via a chemical precipitation method. Then, using thioacetamide (TAA) as the sulfur source, the solid Ni-Mn ellipsoids can be easily converted to hollow ellipsoid Ni-Mn sulfides in ethanol via sulfidation reaction.

Amidoselenation and Amidotelluration of Alkenes using Oxygen as Terminal Oxidant.

A protocol has been established for oxygen-mediated amidoselenation and amidotelluration of alkenes under mild conditions. This method provides a simple route to a series of structurally diverse β-amido selenides and β-amido tellurides in moderate to high yields. The wide substrate scope, good functional group tolerance, ease of large-scale preparation and potential for product derivatization make this reaction attractive for the synthesis of nitrogen-, selenium- and tellurium-containing molecules.

Mesoporous hybrid NiOx-MnOx nanoprisms for flexible solid-state asymmetric supercapacitors.

Mesoporous hybrid NiOx-MnOx nanoprisms have been successfully prepared in this work. The synthesis process involves a facile solvothermal method for preparation of Ni-Mn precursor particles and a subsequent annealing treatment. These mesoporous hybrid NiOx-MnOx nanoprisms have a high surface area of 101.

Ferulic acid inhibits proliferation and promotes apoptosis via blockage of PI3K/Akt pathway in osteosarcoma cell.

Ferulic acid, a ubiquitous phenolic acid abundant in corn, wheat and flax, has potent anti-tumor effect in various cancer cell lines. However, the anti-tumor effect of ferulic acid on osteosarcoma remains unclear. Therefore, we conduct current study to examine the effect of ferulic acid on osteosarcoma cells and explore the underlying mechanisms.

Comparison of NiS2 and α-NiS hollow spheres for supercapacitors, non-enzymatic glucose sensors and water treatment.

NiS2 hollow spheres are successfully prepared by a one-step template free method. Meanwhile, α-NiS hollow spheres can also be synthesized via the calcination of the pre-obtained NiS2 hollow spheres at 400 °C for 1 h in air. The electrochemical performances of the as-prepared NiS2 and α-NiS hollow sphere products are evaluated.

Polydatin Restores Endothelium-Dependent Relaxation in Rat Aorta Rings Impaired by High Glucose: A Novel Insight into the PPARβ-NO Signaling Pathway.

Polydatin, a natural component from Polygonum Cuspidatum, has important therapeutic effects on metabolic syndrome. A novel therapeutic strategy using polydatin to improve vascular function has recently been proposed to treat diabetes-related cardiovascular complications. However, the biological role and molecular basis of polydatin's action on vascular endothelial cells (VECs)-mediated vasodilatation under diabetes-related hyperglycemia condition remain elusive.

Mesoporous ZnS-NiS Nanocomposites for Nonenzymatic Electrochemical Glucose Sensors.

Mesoporous ZnS-NiS composites are prepared via ion- exchange reactions using ZnS as the precursor. The prepared mesoporous ZnS-NiS composite materials have large surface areas (137.9 m(2) g(-1)) compared with the ZnS precursor.

Curcumin attenuates cardiomyocyte hypertrophy induced by high glucose and insulin via the PPARγ/Akt/NO signaling pathway.

Aim: To investigate the potential effect of curcumin on cardiomyocyte hypertrophy and a possible mechanism involving the PPARγ/Akt/NO signaling pathway in diabetes.

Methods: The cardiomyocyte hypertrophy induced by high glucose (25.5mmol/L) and insulin (0.

NiS hollow spheres for high-performance supercapacitors and non-enzymatic glucose sensors.

α-NiS and β-NiS hollow spheres were successfully synthesized via the Kirkendall effect under different hydrothermal conditions. The obtained α-NiS and β-NiS hollow spheres were evaluated as electrode materials for supercapacitors. Importantly, the α-NiS hollow sphere electrode has a large specific capacitance (562.

Stimulated emission in GaN-based laser diodes far below the threshold region.

We identify that the stimulated emission of GaN laser diodes (LDs) emerges far below the traditionally recognized threshold from both optical and electrical experiments. Below the threshold, the linear-polarized stimulated emission has been the dominating part of overall emission and closely related to resonant cavity. Its intensity increases super linearly with current while that of spontaneous emission increases almost linearly.

In situ preparation of fluorescent CdTe quantum dots with small thiols and hyperbranched polymers as co-stabilizers.

A new strategy for in situ preparation of highly fluorescent CdTe quantum dots (QDs) with 3-mercaptopropionic acid (MPA) and hyperbranched poly(amidoamine)s (HPAMAM) as co-stabilizers was proposed in this paper. MPA and HPAMAM were added in turn to coordinate Cd2+. After adding NaHTe and further microwave irradiation, fluorescent CdTe QDs stabilized by MPA and HPAMAM were obtained.

Ferric phosphate hydroxide microcrystals for highly efficient visible-light-driven photocatalysts.

Fe4(OH)3(PO4)3 microcrystals are successfully synthesized by a simple hydrothermal method. Due to a possible self-etching mechanism, different morphologies of Fe4(OH)3(PO4)3 microcrystals are obtained. Several reactions with different temperatures and times are performed to confirm the supposed self-etching mechanism.

Few-layered CoHPO4 · 3H2O ultrathin nanosheets for high performance of electrode materials for supercapacitors.

Ultrathin cobalt phosphate (CoHPO4 · 3H2O) nanosheets are successfully synthesized by a one pot hydrothermal method. Novel CoHPO4 · 3H2O ultrathin nanosheets are assembled for constructing the electrodes of supercapacitors. Benefiting from the nanostructures, the as-prepared electrode shows a specific capacitance of 413 F g(-1), and no obvious decay even after 3000 charge-discharge cycles.

Facile synthesis of porous ZnO-NiO composite micropolyhedrons and their application for high power supercapacitor electrode materials.

Porous ZnO-NiO composite micropolyhedrons have been successfully synthesized by calcination of mixed oxalate (Zn(0.9)Ni(0.1)(C(2)O(4))(2)·nH(2)O) precursors in air.

[Study of rotator phase and phase transition of short-chain alkane by means of Raman spectroscopy].

Raman spectroscopy was used to investigate the phase transition of n-hexacosane for real-time cooling run. In the cooling process, the n-hexacosane experienced the melt phase --> rotator phase --> monoclinic crystal phase transition. The changes in band intensity and frequency in the CH2 bending, CH2 twisting, skeletal C-C stretching, and CH3 rocking regions were mainly analyzed in order to know the changing sequence and process of these vibrational modes, and to reflect the relationship between these vibrational modes and molecular structure.

[Low-temperature-dependent Raman study on A1 (LO) mode of 6H-SiC].

Variable temperature method was lent for low temperature Raman study on bulk monocrystal 6H-SiC in the temperature range from 80 to 320 K. Some Raman folding modes of 6H-SiC were assigned in the spectrum. The peak position and line width of optical phonon A1 (LO) versus temperature mainly below RT was focused on by 3-phonon and 4-phonon models.