Gold nanoclusters stabilized with dopa-containing ligands: Catalyst-indicator integrated probe for tumor cell screening.

Elevated hydrogen peroxide (HO) levels not only inflict cellular damage but also serve as a harbinger for various diseases. Tumor cells, in particular, often exhibit an abundance of HO. Hence, the detection of this pivotal molecule assumes paramount importance in monitoring physiological states and expediting cancer diagnosis.

An Investigation of the Magnitude of the Role of Different Plant Species in Grassland Communities on Species Diversity, China.

In this study, we selected four grassland plots in Altai forest area and used the field survey method of "two-valued occurrence" to obtain the occurrence data of each plant species in the plots so as to calculate the species diversity index value of the community as a whole and the species diversity index value of each plant species not present in the community and to make use of the difference between these two diversity indices to determine the role of each plant species in the overall species diversity of the community. The difference between these two diversity indices was used to investigate the role of each plant species in the overall species diversity of the community. The results show the following: (1) In the grassland of the Altai forest area in Xinjiang, , , , , and are the dominant families, among which the genera , , , , , and are the dominant genera.

The influence of Chinese typography on information dissemination in graphic design: based on eye-tracking data.

The arrangement of Chinese characters has a significant impact on the visual effect and information dissemination in graphic design. In traditional Chinese layout, vertical arrangement of characters is predominant, but in recent times, there has been a gradual transition towards horizontal arrangement. To compare the influence of different character arrangement forms on visual meaning generation and information dissemination, This study employed an eye-tracking experiment to investigate two common Chinese character layouts in posters-horizontal and vertical, and collected data such as eye-tracking heatmap, pupil diameter and eye-tracking trajectory map.

Exploring Favorable Supramolecular Interactions of Multifluorinated Aromatics in Dendronized Push-Pull Chromophores for Electro-Optics.

Multifluorinated aromatics serve as supramolecular synthons in the research of organic electro-optic (EO) materials by exploiting π-π stacking interaction between the aromatic hydrocarbon and multifluorinated aromatic groups for performance improvement. However, non-classical hydrogen bonding remains largely unexplored in fluorinated EO dendrimers. In this study, three Fréchet-type generation 1 benzyl ether co-dendrons were synthesized by replacing one benzyl group with 2,3,5,6-tetrafluorobenzyl (p-HFBz), pentafluorobenzyl (CFBz), and 2,3,4,5-tetrafluorobenzyl (o-HFBz) groups, to afford the benzoic acid derivatives D1, D2, and D3, which were further bonded to the donor and π-bridge moieties to afford three co-dendronized push-pull phenyltetraene chromophores EOD1, EOD2, and EOD3, respectively.

A Full-Scale Analysis of Absorption Edges in Dye-Doped Nonlinear Optical Polymers.

A full-scale analysis of the absorption edges by modified Tauc-Lorentz models is essential in determining the optical bandgap and Urbach energy of semiconductors, transparent conductors, ionic compounds, and dielectric materials. This technique has not yet been applied to analyzing organic nonlinear optical (NLO) materials. This problem is tackled by preparing high-quality films of guest-host NLO polymers with a wide thickness range from sub-micron to 200 microns, allowing accurate measurement of full-spectral absorption coefficients of NLO materials over four orders of magnitude by the UV-VIS-NIR spectroscopy.

Neutral Cyanine: Ultra-Stable NIR-II Merocyanines for Highly Efficient Bioimaging and Tumor-Targeted Phototheranostics.

Fluorescence imaging (FLI)-guided phototheranostics using emission from the second near-infrared (NIR-II) window show significant potential for cancer diagnosis and treatment. Clinical imaging-used polymethine ionic indocyanine green (ICG) dye is widely adopted for NIR fluorescence imaging-guided photothermal therapy (PTT) research due to its exceptional photophysical properties. However, ICG has limitations such as poor photostability, low photothermal conversion efficiency (PCE), short-wavelength emission peak, and liver-targeting issues, which restrict its wider use.

Microbiota enterotoxigenic Bacteroides fragilis-secreted BFT-1 promotes breast cancer cell stemness and chemoresistance through its functional receptor NOD1.

Tumor-resident microbiota in breast cancer promotes cancer initiation and malignant progression. However, targeting microbiota to improve the effects of breast cancer therapy has not been investigated in detail. Here, we evaluated the microbiota composition of breast tumors and found that enterotoxigenic Bacteroides fragilis (ETBF) was highly enriched in the tumors of patients who did not respond to taxane-based neoadjuvant chemotherapy.

The developments of cyan emitting phosphors to fulfill the cyan emission gap of white-LEDs.

Future generations of solid-state lighting (SSL) will prioritize the development of innovative luminescent materials with superior characteristics. The phosphors converted into white light-emitting diodes (white LEDs) often have a blue-green cavity. Cyan-emitting phosphor fills the spectral gap and produces "full-visible-spectrum lighting.

Selection of surgical modality for massive splenomegaly in children.

Background: Laparoscopic splenectomy (LS), a treatment for both benign and malignant splenic diseases, can prove technically challenging in patients with massive splenomegaly. In particular, the optimal surgical modality for treating massive splenomegaly in children remains controversial.

Methods: The clinicopathologic data of 289 pediatric patients undergoing splenectomy for massive splenomegaly were studied in a retrospective analysis.

Push-Pull Heptamethines Near the Cyanine Limit Exhibiting Large Quadratic Electro-Optic Effect.

Harnessing the quadratic electro-optic (QEO) of near-infrared polymethine chromophores over broad telecom wavelength bands is a subject of immense potential but remains largely under-investigated. Herein a series of push-pull heptamethines containing the tricyanofuran (TCF) acceptors and indoline or benzo[e]indoline donors are reported. These dipolar chromophores can attain a highly delocalized "cyanine-like" electronic ground state in solvents spanning a wide range of polarities, in some cases even closer to the ideal polymethine state than symmetrical cyanines.

New exploration of creativity: Cross-validation analysis of the factors influencing multiteam digital creativity in the transition phase.

Multiteam digital creativity (MTDC) is a new domain of creativity study that fits the new developments of the digital era, thus scholars have called for exploring MTDC in the fine-graining phase. This paper responds to this call, and adopts two studies and cross-validation analysis to explore the theoretical framework of the impact factors of MTDC in the transition phase. Study 1 adopts the qualitative analysis method of rooted theory to explore a more comprehensive impact factor and to maximize the new theory's saturation.

Development of a Self-Viscosity and Temperature-Compensated Technique for Highly Stable and Highly Sensitive Bead-Based Diffusometry.

Brownian motion, which is a natural phenomenon, has attracted numerous researchers and received extensive studies over the past decades. The effort contributes to the discovery of optical diffusometry, which is commonly used for micro/nano particle sizing. However, the analysis uncertainty caused by the coupling relationship among particle diameter, temperature, and fluid viscosity usually poses a barrier to precise measurement.

Exploration of Digital Creativity: Construction of the Multiteam Digital Creativity Influencing Factor Model in the Action Phase.

Based on multiteam system (MTS) theory and creativity theory, this study explores the influencing factor model of multiteam digital creativity (MTDC) in the action phase through two cross-validation studies, filling a theoretical gap and responding to the research call. Study 1 is a qualitative analysis method to fully explore the relevant influencing factors and enhance the theoretical saturation. Study 2 is an optimized DEMATEL method, known as the CL-WG DEMATEL analysis method, which cross-validates the new theoretical model and measures the centrality of the influencing factors.

Ccl3 enhances docetaxel chemosensitivity in breast cancer by triggering proinflammatory macrophage polarization.

Background: Although the antitumor efficacy of docetaxel (DTX) has long been attributed to the antimitotic activities, its impact on the tumor microenvironment (TME) has recently gained more attention. Macrophages are a major component of the TME and play a critical role in DTX efficacy; however, the underlying action mechanisms remain unclear.

Methods: DTX chemotherapeutic efficacy was demonstrated via both macrophage depletion and C-C motif chemokine ligand 3 (Ccl3)-knockout transgenic allograft mouse model.

Study on the Strip Warpage Issues Encountered in the Flip-Chip Process.

This study successfully established a strip warpage simulation model of the flip-chip process and investigated the effects of structural design and process (molding, post-mold curing, pretreatment, and ball mounting) on strip warpage. The errors between simulated and experimental values were found to be less than 8%. Taguchi analysis was employed to identify the key factors affecting strip warpage, which were discovered to be die thickness and substrate thickness, followed by mold compound thickness and molding temperature.

Ultrastretchable conductive liquid metal composites enabled by adaptive interfacial polarization.

Gallium-based liquid metals (LMs) are emerging candidates for the development of metal/polymer-based flexible circuits in wearable electronics. However, the high surface energies of LMs make them easily depleted from the polymer matrix and therefore substantially suppress the stretchability of the conductive composites. Here, we reveal that a dynamic interplay between the LM and the polyvinylidene fluoride (PVDF) copolymer can help to address these issues.

Rapid and Sensitive Pathogen Detection by DNA Amplification Using Janus Particle-Enabled Rotational Diffusometry.

Rapid and sensitive detection of infectious bacteria is in all-time high demand to prevent the further spread of the infection and allow early medical intervention. In this study, we use rotational diffusometry (RD), a natural phenomenon characterized by Janus particles, to detect pathogens like by performing amplification of specific genes. This biosensing method is used to measure the change in viscosity of the fluid in the presence and absence of DNA in the solution by capturing images of modified microbeads at 10 Hz by a CCD camera followed by cross-correlation algorithm analysis.

Caenorhabditis elegans exhibits positive gravitaxis.

Background: Gravity plays an important role in most life forms on Earth. Yet, a complete molecular understanding of sensing and responding to gravity is lacking. While there are anatomical differences among animals, there is a remarkable conservation across phylogeny at the molecular level.

Facile open-well immunofluorescence enhancement with coplanar-electrodes-enabled optoelectrokinetics and magnetic particles.

Electrokinetic manipulation has been proven powerful in enhancing the sensing capability of general-purpose biochips. However, the close-form configuration of biochips and the required use of low electric conductivity limit their practicability. In this study, an open-well microfluidic system facilitated with coplanar-electrodes-enabled optoelectrokinetic concentration and magnetic particles were therefore developed to overcome these challenges.

TLR4 Knockout Attenuates BDL-induced Liver Cholestatic Injury through Amino Acid and Choline Metabolic Pathways.

The exact mechanism by which knockout of Toll-like receptor 4 (TLR4) attenuates the liver injury remains unclear. The present study aimed to examine the role of TLR4 in the pathogenesis of bile duct ligation (BDL)-induced liver cholestatic injury and the underlying mechanism. Wild type (WT) mice and TLR4 knockout (TLR4-KO) mice were used for the establishment of the BDL model.

Multifactor study of efficacy and recurrence in laparoscopic surgery for inguinal hernia.

Background: Inguinal hernia is a common clinical manifestation in children with a low self-healing rate.

Aim: To determine the effect of laparoscopic surgery on indirect inguinal hernia and the risk factors for postoperative recurrence and to provide a reference for the clinical treatment and prevention of recurrence.

Methods: We selected 360 children who underwent laparoscopic high ligation in our hospital as the laparoscopic group and 120 patients treated for inguinal hernia with conventional surgery as the control group.

Trace Biomolecule Detection with Functionalized Janus Particles by Rotational Diffusion.

Cytokines are small proteins secreted by cells in innate and adaptive immune systems. Abnormal cytokine secretion is often regarded as an early cue of dysregulation of homeostasis due to diseases or infections. Early detection allows early medical intervention.

Analysis of the predictors of surgical treatment and intestinal necrosis in children with intestinal obstruction.

Purpose: To explore the surgical treatment and predictors of intestinal necrosis in children with intestinal obstruction through analyzing blood biochemical indicators, and to establish a predictive model and evaluate its predictive accuracy, sensitivity and specificity.

Methods: The data of children with intestinal obstruction hospitalized in Jiangxi Provincial Children's Hospital from January 2014 to June 2019 were retrospectively analyzed.

Results: Thirty-six substances in the blood of children with successful conservative management and those requiring surgical treatment were significantly different.